Literature DB >> 42615

Rabbit anti-EL4 serum. A reagent which discriminates between murine cytotoxic and suppressor cells.

L Al-Sakkaf, A Cooke, L Heppel, P Hutchings, B Jones.   

Abstract

Antisera against the C57B1 (H-2b) mouse lymphoma, EL4, were prepared in rabbits. After absorption with mouse liver, red cells and thymocytes, the antisera appeared to be cytotoxic for a subpopulation of peripheral T cells. The absorbed antisera blocked the immunosuppressive function observed when spleen cells from mice undergoing a graft versus host reaction were added to cells responding in vitro to sheep erythrocytes. This antiserum was unreactive against the cytotoxic cells also induced in this system. These results substantiate our previous finding that these antisera are specific for T-suppressor as opposed to T-helper or cytotoxic lymphocyte subpopulations.

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Year:  1979        PMID： 42615      PMCID： PMC1457840     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  11 in total

1.  Age-dependent changes in the relative affinity of anti-dinitrophenyl antibodies in mice.

Authors:  S Marshall-Clarke; J H Playfair
Journal:  Immunology       Date:  1975-09       Impact factor: 7.397

2.  Analysis of immunosuppression generated by the graft-versus-host reaction. II. Characterization of the suppression cell and its mechanism of action.

Authors:  F L Shand
Journal:  Immunology       Date:  1976-12       Impact factor: 7.397

3.  The role of the Fc receptor (FcR) of thymus-derived lymphocytes. II. Presence of FcR on suppressor cells and direct involvement in suppression.

Authors:  W H Fridman; D Fradelizi; A Guimezanes; C Plater; J C Leclerc
Journal:  Eur J Immunol       Date:  1977-08       Impact factor: 5.532

4.  Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs.

Authors:  K T Brunner; J Mauel; J C Cerottini; B Chapuis
Journal:  Immunology       Date:  1968-02       Impact factor: 7.397

5.  Suppressor T cells arising in mice undergoing a graft-vs-host response.

Authors:  K Pickel; M K Hoffmann
Journal:  J Immunol       Date:  1977-02       Impact factor: 5.422

6.  Rabbit anti-EL4 serum. A reagent with specificity for a population of murine suppressor cells.

Authors:  L Al-Sakkaf; A Cooke; P Hutchings; B Jones
Journal:  Immunology       Date:  1979-10       Impact factor: 7.397

7.  The relationship between antigenic structure and the requirement for thymus-derived cells in the immune response.

Authors:  M Feldmann; A Easten
Journal:  J Exp Med       Date:  1971-07-01       Impact factor: 14.307

8.  T-cell regulation of antibody responses: demonstration of allotype-specific helper T cells and their specific removal by suppressor T cells.

Authors:  L A Herzenberg; K Okumura; H Cantor; V L Sato; F W Shen; E A Boyse; L A Herzenberg
Journal:  J Exp Med       Date:  1976-08-01       Impact factor: 14.307

9.  Specific enrichment of the suppressor T cell bearing I-J determinants: parallel functional and serological characterizations.

Authors:  K Okumura; T Takemori; T Tokuhisa; T Tada
Journal:  J Exp Med       Date:  1977-11-01       Impact factor: 14.307

10.  Separation of helper T cells from suppressor T cells expressing different Ly components. I. Polyclonal activation: suppressor and helper activities are inherent properties of distinct T-cell subclasses.

Authors:  J Jandinski; H Cantor; T Tadakuma; D L Peavy; C W Pierce
Journal:  J Exp Med       Date:  1976-06-01       Impact factor: 14.307
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  1 in total

1.  Direct staining of mouse T lymphoblasts with fluoresceinated Vicia villosa lectin.

Authors:  I Lang; J P Banga; A M Varey; H Gunn; A Cooke; I M Roitt
Journal:  Immunology       Date:  1982-08       Impact factor: 7.397
  1 in total

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