Literature DB >> 14213

Suppressor T cells arising in mice undergoing a graft-vs-host response.

K Pickel, M K Hoffmann.   

Abstract

We investigated the ability of mice to generate antibody-forming cells when undergoing a graft-vs-host reaction. (C57BL/6 X DBA/2)F1 mice (BDF1) injected with C57BL/6 spleen cells generated suppressor T cells which inhibit antibody synthesis by BDF1 spleen cells in vitro. These T cells arose from the donor inoculum. They differ from helper T cells in size and they act directly on antigen reactive B cells. The suppressor T cells were specifically directed against components of the H-2 region of the reciprocal parental strain (DBA/2 = H-2d) in the hybrid F1 mouse.

Entities:  

Mesh：

Year:  1977        PMID： 14213

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  20 in total

1.  Trans-presentation of donor-derived interleukin 15 is necessary for the rapid onset of acute graft-versus-host disease but not for graft-versus-tumor activity.

Authors:  Bradley W Blaser; Noah R Schwind; Seth Karol; Dennis Chang; Samuel Shin; Sameek Roychowdhury; Brian Becknell; Amy K Ferketich; Donna F Kusewitt; Bruce R Blazar; Michael A Caligiuri
Journal:  Blood       Date:  2006-06-06       Impact factor: 22.113

Review 2.  Effect of graft-versus-host reaction on thymic function.

Authors:  M Fukuzawa; G M Shearer
Journal:  Immunol Res       Date:  1988       Impact factor: 2.829

Review 3.  The role of cytokines in the immunopathogenesis of lupus.

Authors:  B S Handwerger; V Rus; L da Silva; C S Via
Journal:  Springer Semin Immunopathol       Date:  1994

4.  Analysis of age-dependent resistance to murine coronavirus JHM infection in mice.

Authors:  K Pickel; M A Müller; V ter Meulen
Journal:  Infect Immun       Date:  1981-12       Impact factor: 3.441

5.  Antigen-specific induction and regulation of antibody synthesis in cultures of human peripheral blood mononuclear cells.

Authors:  M K Hoffmann
Journal:  Proc Natl Acad Sci U S A       Date:  1980-02       Impact factor: 11.205

6.  Prevention of oral tolerance induction to ovalbumin and enhanced antigen presentation during a graft-versus-host reaction in mice.

Authors:  S Strobel; A M Mowat; A Ferguson
Journal:  Immunology       Date:  1985-09       Impact factor: 7.397

7.  Transfer of specific unresponsiveness to organ allografts by thymocytes. Specific unresponsiveness by thymocyte transfer.

Authors:  W S Hendry; N L Tilney; W M Baldwin; M J Graves; E Milford; T B Strom; C B Carpenter
Journal:  J Exp Med       Date:  1979-05-01       Impact factor: 14.307

8.  Effects of the removal of adherent and phagocytic cells on the spleen cell lymphoproliferative response of tumor-bearing mice.

Authors:  A M Hyde; R B Stagg; R McEachron; R L Nutter
Journal:  Cancer Immunol Immunother       Date:  1985       Impact factor: 6.968

9.  Rabbit anti-EL4 serum. A reagent which discriminates between murine cytotoxic and suppressor cells.

Authors:  L Al-Sakkaf; A Cooke; L Heppel; P Hutchings; B Jones
Journal:  Immunology       Date:  1979-11       Impact factor: 7.397

10.  Capacity of genetically different T lymphocytes to induce lethal graft-versus-host disease correlates with their capacity to generate suppression but not with their capacity to generate anti-F1 killer cells. A non-H-2 locus determines the inability to induce lethal graft-versus-host disease.

Authors:  E H Van Elven; A G Rolink; F V Veen; E Gleichmann
Journal:  J Exp Med       Date:  1981-06-01       Impact factor: 14.307
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