| Literature DB >> 669804 |
B Svennerholm, O Strannegård, E Lycke.
Abstract
Visna virus inoculation of mice before immunization with unrelated antigens caused suppression of humoral and cell-mediated immune responses. The immunosuppressive effect was dependent on the virus dose and time of administration. The number of "background" antibody-producing spleen cells increased slightly after inoculation of Visna virus. Heat treatment of Visna virus abolished its immunosuppressive effect. Replication of Visna virus in mice seemed to be a prerequisite for its immunomodulating effect.Entities:
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Year: 1978 PMID: 669804 PMCID: PMC421871 DOI: 10.1128/iai.20.2.412-417.1978
Source DB: PubMed Journal: Infect Immun ISSN: 0019-9567 Impact factor: 3.441