Literature DB >> 4156831

Putrescine catabolism in mammalian brain.

N Seiler, M J Al-Therib.   

Abstract

In contrast with putrescine (1,4-diaminobutane), which is a substrate of diamine oxidase, monoacetylputrescine is oxidatively deaminated both in vitro and in vivo by monoamine oxidase. The product of this reaction is N-acetyl-gamma-aminobutyrate. The existence of a degradative pathway in mammalian brain for putrescine is shown, which comprises acetylation of putrescine, oxidative deamination of monoacetylputrescine to N-acetyl-gamma-aminobutyrate, transformation of N-acetyl-gamma-aminobutyrate to gamma-aminobutyrate and degradation of gamma-aminobutyrate to CO(2) via the tricarboxylic acid cycle.

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Year:  1974        PMID： 4156831      PMCID： PMC1168460          DOI： 10.1042/bj1440029

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  23 in total

1.  IDENTIFICATION OF THE AMINOALDEHYDES PRODUCED BY THE OXIDATION OF SPERMINE AND SPERMIDINE WITH PURIFIED PLASMA AMINE OXIDASE.

Authors:  C W TABOR; H TABOR; U BACHRACH
Journal:  J Biol Chem       Date:  1964-07       Impact factor: 5.157

2.  Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse.

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Authors:  H H TALLAN; S MOORE; W H STEIN
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4.  An investigation of the intracellular fluid of calf embryo muscle.

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Journal:  Biochem J       Date:  1949       Impact factor: 3.857

5.  The occurrence of gamma-aminobutyric acid in human tissues other than brain.

Authors:  M Zachmann; P Tocci; W L Nyhan
Journal:  J Biol Chem       Date:  1966-03-25       Impact factor: 5.157

6.  Occurrence of monoacetylputrescine in vertebrate tissue.

Authors:  N Seiler; M J Al-Therib; B Knödgen
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1973-05

7.  [Occurrence of gamma-aminobutyric acid and gamma-amino-beta-hydroxybutyric acid in animal tissues].

Authors:  N Seiler; M Wiechmann
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1969-12

8.  Studies on the biosynthetic pathway of polyamines in rat liver.

Authors:  J Jänne
Journal:  Acta Physiol Scand Suppl       Date:  1967

Review 9.  Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine, and related amines.

Authors:  H Tabor; C W Tabor
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1972

10.  Interrelationships between polyamines and nucleic acids. Changes of polyamine and nucleic acid concentrations in the growing fish brain (Salmo irideus Gibb.).

Authors:  N Seiler; U Lamberty
Journal:  J Neurochem       Date:  1973-03       Impact factor: 5.372
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  32 in total

Review 1.  Biosynthesis, degradation and pharmacological importance of the fatty acid amides.

Authors:  Emma K Farrell; David J Merkler
Journal:  Drug Discov Today       Date:  2008-04-03       Impact factor: 7.851

Review 2.  Oxidation of polyamines and brain injury.

Authors:  N Seiler
Journal:  Neurochem Res       Date:  2000-04       Impact factor: 3.996

3.  Aldehyde dehydrogenase from adult human brain that dehydrogenates gamma-aminobutyraldehyde: purification, characterization, cloning and distribution.

Authors:  A Kikonyogo; R Pietruszko
Journal:  Biochem J       Date:  1996-05-15       Impact factor: 3.857

4.  On the metabolism of ornithine in synaptosomal preparations.

Authors:  S P Lapinjoki; A E Pajunen; A E Pulkka; R S Piha
Journal:  Neurochem Res       Date:  1982-06       Impact factor: 3.996

5.  Polyamine metabolism in ripening tomato fruit : I. Identification of metabolites of putrescine and spermidine.

Authors:  R Rastogi; P J Davies
Journal:  Plant Physiol       Date:  1990-11       Impact factor: 8.340

6.  Regulatory interrelations between GABA and polyamines. I. Brain GABA levels and polyamine metabolism.

Authors:  N Seiler; G Bink; J Grove
Journal:  Neurochem Res       Date:  1979-08       Impact factor: 3.996

7.  Evaluation of diamine oxidase activity (DAO) in the rat intestinal mucosa by measuring expired 14CO2 after oral administration of 14C-putrescine.

Authors:  T Bamba; A Sasaki; S Hosoda
Journal:  J Gastroenterol       Date:  1994-02       Impact factor: 7.527

Review 8.  Endogenous ornithine in search for CNS functions and therapeutic applications.

Authors:  N Seiler; G Daune-Anglard
Journal:  Metab Brain Dis       Date:  1993-09       Impact factor: 3.584

9.  Central GABA mechanisms during postnatal development in the rat: neurochemical characteristics.

Authors:  T Hedner; K Iversen; P Lundborg
Journal:  J Neural Transm       Date:  1984       Impact factor: 3.575

10.  Biological monitoring of isocyanates and related amines. I. Determination of 1,6-hexamethylene diamine (HDA) in hydrolysed human urine after oral administration of HDA.

Authors:  T Brorson; G Skarping; J F Sandström; M Stenberg
Journal:  Int Arch Occup Environ Health       Date:  1990       Impact factor: 3.015
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