Literature DB >> 18598910

Biosynthesis, degradation and pharmacological importance of the fatty acid amides.

Emma K Farrell1, David J Merkler.   

Abstract

The identification of two biologically active fatty acid amides, N-arachidonoylethanolamine (anandamide) and oleamide, has generated a great deal of excitement and stimulated considerable research. However, anandamide and oleamide are merely the best-known and best-understood members of a much larger family of biologically occurring fatty acid amides. In this review, we will outline which fatty acid amides have been isolated from mammalian sources, detail what is known about how these molecules are made and degraded in vivo, and highlight their potential for the development of novel therapeutics.

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Year:  2008        PMID： 18598910      PMCID： PMC2667908          DOI： 10.1016/j.drudis.2008.02.006

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  118 in total

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