Literature DB >> 481678

Regulatory interrelations between GABA and polyamines. I. Brain GABA levels and polyamine metabolism.

N Seiler, G Bink, J Grove.   

Abstract

Elevation of brain GABA levels by GABA-T inhibition is accompanied by a decrease of S-adenosylmethionine decarboxylase activity. This is followed by an increase of ornithine decarboxylase activity and a severalfold increase of brain putrescine levels. Spermidine and spermine levels are not significantly affected under these conditions. These unexpected findings support a regulatory interaction between GABA and polyamine metabolism.

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Year:  1979        PMID： 481678     DOI： 10.1007/bf00964637

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  41 in total

1.  Acetyl-coenzyme A: 1,4-diaminobutane N-acetyltransferase: activity in rat brain during development, in experimental brain tumours and in brains of fish of different metabolic activity.

Authors:  N Seiler; U Lamberty; M J Al-Therib
Journal:  J Neurochem       Date:  1975-04       Impact factor: 5.372

2.  PURIFICATION AND PROPERTIES OF RAT LIVER ORNITHINE DELTA-TRANSAMINASE.

Authors:  H J STRECKER
Journal:  J Biol Chem       Date:  1965-03       Impact factor: 5.157

3.  The effect of 4-amino hex-5-ynoic acid (gamma-acetylenic GABA, gammma-ethynyl GABA) a catalytic inhibitor of GABA transaminase, on brain GABA metabolism in vivo.

Authors:  M J Jung; B Lippert; B W Metcalf; P J Schechter; P Böhlen; A Sjoerdsma
Journal:  J Neurochem       Date:  1977-04       Impact factor: 5.372

4.  Studies on the formation of gamma-aminobutyric acid from putrescine in rat organs and purification of its synthetic enzyme from rat intestine.

Authors:  M Tsuji; T Nakajima
Journal:  J Biochem       Date:  1978-05       Impact factor: 3.387

5.  On the purification of L-ornithine decarboxylase from rat prostate and effects of thiol compounds on the enzyme.

Authors:  J Jänne; H G Williams-Ashman
Journal:  J Biol Chem       Date:  1971-03-25       Impact factor: 5.157

6.  Effects of gabaculine, a new potent inhibitor of gamma-amonobutyrate transaminase, on the brain gamma-amonobutyrate content and convulsions in mice.

Authors:  Y Matsui; T Deguchi
Journal:  Life Sci       Date:  1977-04-01       Impact factor: 5.037

7.  Initial characterization of a HTC cell variant partially resistant to the anti-proliferative effect of ornithine decarboxylase inhibitors.

Authors:  P S Mamont; M C Duchesne; J Grove; C Tardif
Journal:  Exp Cell Res       Date:  1978-09       Impact factor: 3.905

8.  Ornithine decarboxylase and adenosylmethionine decarboxylase in mouse brain--effect of electrical stimulation.

Authors:  A E Pajunen; O A Hietala; E L Virransalo; R S Piha
Journal:  J Neurochem       Date:  1978-01       Impact factor: 5.372

9.  4-aminobutyrate in mammalian putrescine catabolism.

Authors:  N Seiler; B Eichentopf
Journal:  Biochem J       Date:  1975-11       Impact factor: 3.857

10.  gamma-Vinyl GABA (4-amino-hex-5-enoic acid), a new selective irreversible inhibitor of GABA-T: effects on brain GABA metabolism in mice.

Authors:  M J Jung; B Lippert; B W Metcalf; P Böhlen; P J Schechter
Journal:  J Neurochem       Date:  1977-11       Impact factor: 5.372
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  8 in total

Review 1.  Oxidation of polyamines and brain injury.

Authors:  N Seiler
Journal:  Neurochem Res       Date:  2000-04       Impact factor: 3.996

Review 2.  Glutamate, GABA, and CNS disease: a review.

Authors:  J E Walker
Journal:  Neurochem Res       Date:  1983-04       Impact factor: 3.996

Review 3.  Cellular compartments of GABA in brain and their relationship to anticonvulsant activity.

Authors:  M J Iadarola; K Gale
Journal:  Mol Cell Biochem       Date:  1981-09-25       Impact factor: 3.396

4.  Diurnal levels of polyamines and activities of ornithine and S-adenosyl-L-methionine decarboxylases in mouse brain.

Authors:  S P Lapinjoki; O A Hietala; A E Pajunen; R S Piha
Journal:  Neurochem Res       Date:  1981-04       Impact factor: 3.996

5.  Regulatory interrelations between GABA and polyamines. II. Effect of GABA on ornithine decarboxylase and putrescine levels in cell culture.

Authors:  P P McCann; J M Hornsperger; N Seiler
Journal:  Neurochem Res       Date:  1979-08       Impact factor: 3.996

6.  5-Fluoromethylornithine, an irreversible and specific inhibitor of L-ornithine:2-oxo-acid aminotransferase.

Authors:  G Daune; F Gerhart; N Seiler
Journal:  Biochem J       Date:  1988-07-15       Impact factor: 3.857

7.  Polyamine reutilization and turnover in brain.

Authors:  N Seiler; F N Bolkenius
Journal:  Neurochem Res       Date:  1985-04       Impact factor: 3.996

8.  Interrelationships between ornithine, glutamate, and GABA. II. Consequences of inhibition of GABA-T and ornithine aminotransferase in brain.

Authors:  G Daune; N Seiler
Journal:  Neurochem Res       Date:  1988-01       Impact factor: 3.996
  8 in total

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