Literature DB >> 4129801

Highly purified papain-solubilized HL-A antigens contain beta2-microglobulin.

P A Peterson, L Rask, J B Lindblom.   

Abstract

HL-A antigens comprising 11 different antigenic specificities were isolated after papain solubilization of spleen-cell membrane constituents. During the entire purification procedure, beta(2)-microglobulin appeared together with the HL-A antigens. The highly purified antigens were composed of two polypeptide chains. The large subunit carried the antigenic specificity whereas the small polypeptide chain was very similar, if not identical, to beta(2)-microglobulin. The two HL-A antigen polypeptide chains were held together by noncovalent interactions only, and beta(2)-microglobulin, isolated from urine, could replace the small subunit in forming a complex with the large polypeptide chain. The topographical relationship in the cell membrane between beta(2)-microglobulin and the large HL-A antigen polypeptide chain is unknown. The two polypeptide chains may be fortuitously bound as a result of the solubilization procedure.

Entities:  

Mesh：

Substances：

Year:  1974        PMID： 4129801      PMCID： PMC387926          DOI： 10.1073/pnas.71.1.35

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  21 in total

Review 1.  Biochemical properties of histocompatibility antigens.

Authors:  S G Nathenson
Journal:  Annu Rev Genet       Date:  1970       Impact factor: 16.830

2.  Characterization of soluble substances in plasma carrying HL-A alloantigenic activity and HL-A common antigenic activity.

Authors:  Y Miyakawa; N Tanigaki; V P Kreiter; G E Moore; D Pressman
Journal:  Transplantation       Date:  1973-03       Impact factor: 4.939

3.  Combination of specific antibodies with the human vitamin A-transporting protein complex.

Authors:  A Vahlquist; P A Peterson
Journal:  J Biol Chem       Date:  1973-06-10       Impact factor: 5.157

4.  HL-A substances from human spleens.

Authors:  A R Sanderson
Journal:  Nature       Date:  1968-10-12       Impact factor: 49.962

Review 5.  Transplantation antigens.

Authors:  R A Reisfeld; B D Kahan
Journal:  Adv Immunol       Date:  1970       Impact factor: 3.543

6.  2 -Microglobulin--a free immunoglobulin domain.

Authors:  P A Peterson; B A Cunningham; I Berggård; G M Edelman
Journal:  Proc Natl Acad Sci U S A       Date:  1972-07       Impact factor: 11.205

7.  Initiation of protein synthesis at an unusual position in an immunoglobulin gene?

Authors:  O Smithies; M D Poulik
Journal:  Science       Date:  1972-01-14       Impact factor: 47.728

8.  Differentiation of glomerular, tubular, and normal proteinuria: determinations of urinary excretion of beta-2-macroglobulin, albumin, and total protein.

Authors:  P A Peterson; P E Evrin; I Berggård
Journal:  J Clin Invest       Date:  1969-07       Impact factor: 14.808

9.  The relationship between 2 -microglobulin and immunoglobulin in cultured human lymphoid cell lines.

Authors:  T H Hütteroth; H Cleve; S D Litwin; M D Poulik
Journal:  J Exp Med       Date:  1973-03-01       Impact factor: 14.307

10.  Mouse isoantigens: separation of soluble TL (thymus-leukemia) antigen from soluble H-2 histocompatibility antigen by column chromatography.

Authors:  D A Davies; E A Boyse; L J Old; E Stockert
Journal:  J Exp Med       Date:  1967-04-01       Impact factor: 14.307
View more
  56 in total

1.  Amino acid sequence of an immunoglobulin-like HLA antigen heavy chain domain.

Authors:  L Trägärdh; L Rask; K Wiman; J Fohlman; P A Peterson
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205

2.  Evidence for tryosine peptide homologies in the HLA antigens system.

Authors:  C Cunningham-Rundles; C Jersild; A Svejgaard; B Dupont; R A Good
Journal:  Proc Natl Acad Sci U S A       Date:  1975-12       Impact factor: 11.205

3.  Evolutionary relationship between immunoglobulins and transplantation antigens.

Authors:  P A Peterson; L Rask; K Sege; L Klareskog; H Anundi; L Ostberg
Journal:  Proc Natl Acad Sci U S A       Date:  1975-04       Impact factor: 11.205

4.  The lymphocyte plasma membrane: locus of control in the immune response.

Authors:  L M Jerry; A K Sullivan
Journal:  In Vitro       Date:  1976-03

5.  Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites.

Authors:  H T Orr; J A Lopez de Castro; P Parham; H L Ploegh; J L Strominger
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

6.  Cell-free synthesis and segregation of beta 2-microglobulin.

Authors:  V R Lingappa; B A Cunningham; S M Jazwinski; T P Hopp; G Blobel; G M Edelman
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

7.  Modification of beta-2-microglobulin in sera from patients with small cell lung cancer: evidence for involvement of a serine protease.

Authors:  M H Nissen; O J Bjerrum; T Plesner; M Wilken; M Rørth
Journal:  Clin Exp Immunol       Date:  1987-02       Impact factor: 4.330

8.  Increased in vivo secretory activity of neutrophil granulocytes in patients with psoriasis and palmoplantar pustulosis.

Authors:  A Lundin; L Håkansson; R Hällgren; G Michaëlsson; P Venge
Journal:  Arch Dermatol Res       Date:  1985       Impact factor: 3.017

9.  Molecular association between transplantation antigens and cell surface antigen in adenovirus-transformed cell line.

Authors:  S Kvist; L Ostberg; H Persson; L Philipson; P A Peterson
Journal:  Proc Natl Acad Sci U S A       Date:  1978-11       Impact factor: 11.205

10.  Beta 2-microglobulin and its binding activity in serum from patients with SLE.

Authors:  P E Evrin; T Ström
Journal:  Ann Rheum Dis       Date:  1984-04       Impact factor: 19.103
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.