Literature DB >> 4113240

Viral and cellular DNA polymerase: comparison of activities with synthetic and natural RNA templates.

M S Robert, R G Smith, R C Gallo, P S Sarin, J W Abrell.   

Abstract

Two DNA polymerases purified from normal human lymphocytes are distinguishable from the viral reverse transcriptases of avian myeloblastosis virus and Mason-Pfizer monkey virus by their relative affinity for select templates. In this respect, the activity of the two normal human lymphocyte polymerases closely resembles the activity of Escherichia coli DNA polymerase 1. The viral and cellular DNA polymerases are equally active with the nonspecific template, poly(rA) . poly(dT). Criteria for distinguishing the activity of viral reverse transcriptase are discussed.

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Year:  1972        PMID： 4113240     DOI： 10.1126/science.176.4036.798

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  26 in total

1.  Micromethod for assaying reverse transcriptase of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus.

Authors:  T J Spira; L H Bozeman; R C Holman; D T Warfield; S K Phillips; P M Feorino
Journal:  J Clin Microbiol       Date:  1987-01       Impact factor: 5.948

Review 2.  [Molecular basis of viral induced tumors (author's transl)].

Authors:  P Chandra; D Gericke; F Zunino; R Thorbeck
Journal:  Klin Wochenschr       Date:  1973-08-15

3.  Lack of sequence homology between the 70S RNA of various RNA tumor viruses and the DNA of simian virus 40 or polyoma virus.

Authors:  R E Gallagher; A S Levine; D H Gillespie; R C Gallo
Journal:  J Virol       Date:  1973-06       Impact factor: 5.103

4.  DNA-dependent DNA polymerases I and II from normal human-blood lymphocytes.

Authors:  R G Smith; R C Gallo
Journal:  Proc Natl Acad Sci U S A       Date:  1972-10       Impact factor: 11.205

5.  Adrenal corticosteroids enhance production of type-C virus induced by 5-iodo-2'-deoxyuridine from cultured mouse fibroblasts.

Authors:  M Paran; R C Gallo; L S Richardson; A M Wu
Journal:  Proc Natl Acad Sci U S A       Date:  1973-08       Impact factor: 11.205

6.  Murine intracisternal type A particles: a biochemical characterization.

Authors:  F Wong-Staal; M S Reitz; C D Trainor; R C Gallo
Journal:  J Virol       Date:  1975-10       Impact factor: 5.103

7.  Transcription of 70S RNA by DNA polymerases from mammalian RNA viruses.

Authors:  J W Abrell; M S Reitz; R C Gallo
Journal:  J Virol       Date:  1975-12       Impact factor: 5.103

8.  Separation of ribonuclease H and RNA directed DNA polymerase (reverse transcriptase) of murine type-C RNA tumor viruses.

Authors:  A M Wu; M G Sarngadharan; R C Gallo
Journal:  Proc Natl Acad Sci U S A       Date:  1974-05       Impact factor: 11.205

9.  Purification of avian myeloblastosis virus DNA polymerase by affinity chromatography on polycytidylate-agarose.

Authors:  S L Marcus; M J Modak; L F Cavalieri
Journal:  J Virol       Date:  1974-10       Impact factor: 5.103

10.  Primate RNA tumor virus-like DNA synthesized endogenously by RNA-dependent DNA polymerase in virus-like particles from fresh human acute leukemic blood cells.

Authors:  R C Gallo; N R Miller; W C Saxinger; D Gillespie
Journal:  Proc Natl Acad Sci U S A       Date:  1973-11       Impact factor: 11.205
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