Literature DB >> 4084311

An acid metabolite of cyclosporine.

N R Hartman, L A Trimble, J C Vederas, I Jardine.   

Abstract

The primary biliary metabolite of cyclosporine has been isolated from rabbit and human bile. The material has been identified by mass spectrometry and by nuclear magnetic resonance spectrometry as an acidic metabolite of cyclosporine in which the eta-methyl group of the cyclosporine-specific nine carbon amino acid #1 has been oxidized to an alpha, beta unsaturated carboxylic acid functionality. This major cyclosporine metabolite is inactive in a phytohemagglutinin stimulated lymphocyte proliferation assay.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 4084311     DOI： 10.1016/0006-291x(85)91230-6

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  10 in total

1.  Identification of the Aldehydic Metabolites.

Authors:  H Hashem; R Venkataramanan; G J Burckart; L Makowka; T E Starzl; E Fu; L K Wong
Journal:  Transplant Proc       Date:  1988-02       Impact factor: 1.066

Review 2.  The cyclosporins.

Authors:  Z Rehácek
Journal:  Folia Microbiol (Praha)       Date:  1995       Impact factor: 2.099

3.  The effect of cyclosporine A on murine trichinellosis.

Authors:  J Leiro; M T Santamarina; L Sernández; M L Sanmartín; F M Ubeira
Journal:  Parasitol Res       Date:  1989       Impact factor: 2.289

4.  Species-specific cyclosporine metabolism.

Authors:  R Venkataramanan; C P Wang; K Habucky; R J Ptachcinski; G J Burckart; B Koneru; R Baker; S Todo; T E Starzl
Journal:  Transplant Proc       Date:  1988-04       Impact factor: 1.066

5.  A prospective study of cyclosporine concentration in relation to its therapeutic effect and toxicity after renal transplantation.

Authors:  A Lindholm; R Dahlqvist; G G Groth; F Sjöqvist
Journal:  Br J Clin Pharmacol       Date:  1990-09       Impact factor: 4.335

6.  Ciclosporin metabolite pattern in blood and urine of kidney graft patients in relation to liver function.

Authors:  J S Bleck; H J Schlitt; U Christians; R Schottmann; C Thiesemann; S Strohmeyer; K Kohlhaw; K Wonigeit; R Pichlmayr; K F Sewing
Journal:  Eur J Clin Pharmacol       Date:  1991       Impact factor: 2.953

7.  Isolation of 10 cyclosporine metabolites from human bile.

Authors:  C P Wang; N R Hartman; R Venkataramanan; I Jardine; F T Lin; J E Knapp; T E Starzl; G J Burckart
Journal:  Drug Metab Dispos       Date:  1989 May-Jun       Impact factor: 3.922

8.  Excretion of cyclosporine and its metabolites in human bile.

Authors:  G J Burckart; T E Starzl; R Venkataramanan; H Hashim; L Wong; P Wang; L Makowka; A Zeevi; R J Ptachcinski; J E Knapp
Journal:  Transplant Proc       Date:  1986-12       Impact factor: 1.066

Review 9.  Cyclosporin clinical pharmacokinetics.

Authors:  A Fahr
Journal:  Clin Pharmacokinet       Date:  1993-06       Impact factor: 6.447

Review 10.  Clinical pharmacokinetics in organ transplant patients.

Authors:  R Venkataramanan; K Habucky; G J Burckart; R J Ptachcinski
Journal:  Clin Pharmacokinet       Date:  1989-03       Impact factor: 6.447
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.