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Literature DB >> 4073875

Differential effect of sinefungin and its analogs on the multiplication of three Leishmania species.

P Paolantonacci, F Lawrence, M Robert-Géro.

Abstract

Sinefungin and seven analogs were evaluated in vitro for activity against promastigote multiplication of Leishmania donovani, L. tropica, and L. enrietti. Of these compounds, sinefungin, the cyclic derivative, and A9145C were leishmanicidal at concentrations ranging from 0.13 to 2.6 microM. Sinefungin was the most active of these three compounds against L. donovani, and A9145C was most active against L. enrietti. None of the remaining derivatives exhibited significant activity against any one of the three species at the highest dose tested. All agents were assayed for activity against protein methylases I and III. The results of these tests showed that there is no relationship between the inhibition of growth and inhibition of protein methylases I and III.

Entities: Chemical Disease Mutation Species

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Year: 1985 PMID： 4073875 PMCID： PMC180298 DOI： 10.1128/AAC.28.4.528

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

14 in total

1. The antifungal antibiotic sinefungin as a very active inhibitor of methyltransferases and of the transformation of chick embryo fibroblasts by Rous sarcoma virus.

Authors: M Vedel; F Lawrence; M Robert-Gero; E Lederer
Journal: Biochem Biophys Res Commun Date: 1978-11-14 Impact factor: 3.575

2. Protein methylases in hepatomas.

Authors: W K Paik; H W Lee; H P Morris
Journal: Cancer Res Date: 1972-01 Impact factor: 12.701

3. Amoebicidal activity of the antifungal antibiotic sinefungin against Entamoeba histolytica.

Authors: A Ferrante; I Ljungström; G Huldt; E Lederer
Journal: Trans R Soc Trop Med Hyg Date: 1984 Impact factor: 2.184

4. Plasmodium falciparum: antimalarial activity in culture of sinefungin and other methylation inhibitors.

Authors: W Trager; M Tershakovec; P K Chiang; G L Cantoni
Journal: Exp Parasitol Date: 1980-08 Impact factor: 2.011

5. Inhibition of methyltransferases by some new analogs of S-adenosylhomocysteine.

Authors: R W Fuller; R Nagarajan
Journal: Biochem Pharmacol Date: 1978 Impact factor: 5.858

6. Allopurinol ribonucleoside as an antileishmanial agent. Biological effects, metabolism, and enzymatic phosphorylation.

Authors: D J Nelson; S W LaFon; J V Tuttle; W H Miller; R L Miller; T A Krenitsky; G B Elion; R L Berens; J J Marr
Journal: J Biol Chem Date: 1979-11-25 Impact factor: 5.157

7. Sinefungin, a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication.

Authors: C S Pugh; R T Borchardt; H O Stone
Journal: J Biol Chem Date: 1978-06-25 Impact factor: 5.157

8. Inhibitory activity of sinefungin and SIBA (5'-deoxy-5'-S-isobutylthio-adenosine) on the growth of promastigotes and amastigotes of different species of Leishmania.

Authors: U Bachrach; L F Schnur; J El-On; C L Greenblatt; E Pearlman; M Robert-Gero; E Lederer
Journal: FEBS Lett Date: 1980-12-01 Impact factor: 4.124

9. Antitrypanosomal activity of sinefungin.

Authors: D K Dube; G Mpimbaza; A C Allison; E Lederer; L Rovis
Journal: Am J Trop Med Hyg Date: 1983-01 Impact factor: 2.345

10. Anti-leishmanial effect of allopurinol ribonucleoside and the related compounds, allopurinol, thiopurinol, thiopurinol ribonucleoside, and of formycin B, sinefungin and the lepidine WR6026.

Authors: R A Neal; S L Croft; D J Nelson
Journal: Trans R Soc Trop Med Hyg Date: 1985 Impact factor: 2.184

9 in total

1. Methylation inhibitors can increase the rate of cytosine deamination by (cytosine-5)-DNA methyltransferase.

Authors: J M Zingg; J C Shen; A S Yang; H Rapoport; P A Jones
Journal: Nucleic Acids Res Date: 1996-08-15 Impact factor: 16.971

2. High affinity S-Adenosylmethionine plasma membrane transporter of Leishmania is a member of the folate biopterin transporter (FBT) family.

Authors: Larbi Dridi; Amin Ahmed Ouameur; Marc Ouellette
Journal: J Biol Chem Date: 2010-04-20 Impact factor: 5.157

Differential effect of sinefungin and its analogs on the multiplication of three Leishmania species.

1. The antifungal antibiotic sinefungin as a very active inhibitor of methyltransferases and of the transformation of chick embryo fibroblasts by Rous sarcoma virus.

2. Protein methylases in hepatomas.

3. Amoebicidal activity of the antifungal antibiotic sinefungin against Entamoeba histolytica.

4. Plasmodium falciparum: antimalarial activity in culture of sinefungin and other methylation inhibitors.

5. Inhibition of methyltransferases by some new analogs of S-adenosylhomocysteine.

6. Allopurinol ribonucleoside as an antileishmanial agent. Biological effects, metabolism, and enzymatic phosphorylation.

7. Sinefungin, a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication.

8. Inhibitory activity of sinefungin and SIBA (5'-deoxy-5'-S-isobutylthio-adenosine) on the growth of promastigotes and amastigotes of different species of Leishmania.

9. Antitrypanosomal activity of sinefungin.

10. Anti-leishmanial effect of allopurinol ribonucleoside and the related compounds, allopurinol, thiopurinol, thiopurinol ribonucleoside, and of formycin B, sinefungin and the lepidine WR6026.

1. Methylation inhibitors can increase the rate of cytosine deamination by (cytosine-5)-DNA methyltransferase.

2. High affinity S-Adenosylmethionine plasma membrane transporter of Leishmania is a member of the folate biopterin transporter (FBT) family.

3. Characterization of sinefungin-resistant Leishmania donovani promastigotes.

4. Sinefungin shares AdoMet-uptake system to enter Leishmania donovani promastigotes.

5. Molecular target of the antileishmanial action of sinefungin.

6. Virtual high-throughput screening identifies mycophenolic acid as a novel RNA capping inhibitor.

7. Genomewide Analysis of Mode of Action of the S-Adenosylmethionine Analogue Sinefungin in Leishmania infantum.

Review 8. The RNA capping machinery as an anti-infective target.

9. Sinefungin, a natural nucleoside analogue of S-adenosylmethionine, inhibits Streptococcus pneumoniae biofilm growth.