Literature DB >> 6130709

Antitrypanosomal activity of sinefungin.

D K Dube, G Mpimbaza, A C Allison, E Lederer, L Rovis.   

Abstract

Sinefungin, a naturally occurring antifungal antibiotic nucleoside containing an ornithine residue, linked by a C-C bond to C-5' of adenosine, cures mice infected with Trypanosoma brucei brucei, T. congolense, or T. vivax; the effect of the drug is more pronounced towards T. congolense. Anti-trypanosomal activity of sinefungin could be the result of the inhibition of transmethylation reactions or of polyamine biosynthesis--or both--in parasites.

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Year:  1983        PMID： 6130709     DOI： 10.4269/ajtmh.1983.32.31

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  17 in total

1.  Genetic mapping reveals that sinefungin resistance in Toxoplasma gondii is controlled by a putative amino acid transporter locus that can be used as a negative selectable marker.

Authors:  Michael S Behnke; Asis Khan; L David Sibley
Journal:  Eukaryot Cell       Date:  2014-12-05

2.  Efficacy of experimental trypanocidal compounds against a multiple drug-resistant Trypanosoma brucei brucei stock in mice.

Authors:  E Zweygarth; D Röttcher
Journal:  Parasitol Res       Date:  1989       Impact factor: 2.289

3.  Curative and preventive anticryptosporidium activities of sinefungin in an immunosuppressed adult rat model.

Authors:  P Brasseur; D Lemeteil; J J Ballet
Journal:  Antimicrob Agents Chemother       Date:  1993-04       Impact factor: 5.191

4.  Synergism between 9-deazainosine and DL-alpha-difluoromethylornithine in treatment of experimental African trypanosomiasis.

Authors:  C J Bacchi; R L Berens; H C Nathan; R S Klein; I A Elegbe; K V Rao; P P McCann; J J Marr
Journal:  Antimicrob Agents Chemother       Date:  1987-09       Impact factor: 5.191

5.  A convergent synthesis of carbocyclic sinefungin and its C5 epimer.

Authors:  Arun K Ghosh; Kai Lv
Journal:  European J Org Chem       Date:  2014-10-01

6.  High affinity S-Adenosylmethionine plasma membrane transporter of Leishmania is a member of the folate biopterin transporter (FBT) family.

Authors:  Larbi Dridi; Amin Ahmed Ouameur; Marc Ouellette
Journal:  J Biol Chem       Date:  2010-04-20       Impact factor: 5.157

Review 7.  The biosynthesis of nitrogen-, sulfur-, and high-carbon chain-containing sugars.

Authors:  Chia-I Lin; Reid M McCarty; Hung-wen Liu
Journal:  Chem Soc Rev       Date:  2013-01-25       Impact factor: 54.564

8.  Trypanosoma brucei spliced-leader RNA methylations are required for trans splicing in vivo.

Authors:  K P McNally; N Agabian
Journal:  Mol Cell Biol       Date:  1992-11       Impact factor: 4.272

9.  Feeder layer-free in vitro assay for screening antitrypanosomal compounds against Trypanosoma brucei brucei and T. b. evansi.

Authors:  R Kaminsky; E Zweygarth
Journal:  Antimicrob Agents Chemother       Date:  1989-06       Impact factor: 5.191

10.  Fate of soluble methionine in African trypanosomes: effects of metabolic inhibitors.

Authors:  C J Bacchi; B Goldberg; J Garofalo-Hannan; D Rattendi; P Lyte; N Yarlett
Journal:  Biochem J       Date:  1995-08-01       Impact factor: 3.857
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