Literature DB >> 6099924

Amoebicidal activity of the antifungal antibiotic sinefungin against Entamoeba histolytica.

A Ferrante, I Ljungström, G Huldt, E Lederer.   

Abstract

The antifungal antibiotic sinefungin, a potent inhibitor of methyl transferases and a potential inhibitor of polyamine biosynthesis, exhibited marked cytolytic activity against Entamoeba histolytica in vitro with respect to all the amoeba strains tested. Strains of high and low virulence displayed equal sensitivity to the antibiotic. Minimal Amoebicidal Concentration was 5 to 10 micrograms/ml.

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Year:  1984        PMID： 6099924     DOI： 10.1016/0035-9203(84)90039-7

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN： 0035-9203            Impact factor:   2.184


  7 in total

1.  Curative and preventive anticryptosporidium activities of sinefungin in an immunosuppressed adult rat model.

Authors:  P Brasseur; D Lemeteil; J J Ballet
Journal:  Antimicrob Agents Chemother       Date:  1993-04       Impact factor: 5.191

2.  Carbocyclic Sinefungin.

Authors:  Xueqiang Yin; Guoxia Zhao; Stewart W Schneller
Journal:  Tetrahedron Lett       Date:  2007-07-09       Impact factor: 2.415

3.  Molecular target of the antileishmanial action of sinefungin.

Authors:  L L Nolan
Journal:  Antimicrob Agents Chemother       Date:  1987-10       Impact factor: 5.191

4.  Regulation of sinefungin biosynthesis by the wild-type strain and mutants of Streptomyces incarnatus.

Authors:  H Malina; M Robert-Gero
Journal:  Appl Environ Microbiol       Date:  1988-05       Impact factor: 4.792

5.  Differential effect of sinefungin and its analogs on the multiplication of three Leishmania species.

Authors:  P Paolantonacci; F Lawrence; M Robert-Géro
Journal:  Antimicrob Agents Chemother       Date:  1985-10       Impact factor: 5.191

6.  Draft Genome Sequence of Streptomyces incarnatus NRRL8089, which Produces the Nucleoside Antibiotic Sinefungin.

Authors:  Kenshiro Oshima; Masahira Hattori; Hitomi Shimizu; Koji Fukuda; Michiko Nemoto; Kenji Inagaki; Takashi Tamura
Journal:  Genome Announc       Date:  2015-07-09

7.  Sinefungin resistance of Saccharomyces cerevisiae arising from Sam3 mutations that inactivate the AdoMet transporter or from increased expression of AdoMet synthase plus mRNA cap guanine-N7 methyltransferase.

Authors:  Sushuang Zheng; Stewart Shuman; Beate Schwer
Journal:  Nucleic Acids Res       Date:  2007-10-11       Impact factor: 16.971
  7 in total

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