Literature DB >> 40646

Comparative studies on immunologically and non-immunologically produced slow-reacting substances from man, guinea-pig and rat.

H R Morris, P J Piper, G W Taylor, J R Tippins.   

Abstract

1 Slow-reacting substance of anaphylaxis (SRS-A) was produced by antigen challenge of passively sensitized human lung and actively sensitized guinea-pig lung. 2 A slow-reacting substance (SRS) was prepared from the peritoneal fluid of rats treated with calcium ionophore A23187. 3 These substances were extensively purified by charcoal adsorption, Sephadex G-15 gel filtration, ether extraction and reverse phase high pressure liquid chromatography. 4 The three substances are pharmacologically, chemically and chromatographically indistinguishable. 5 Our data suggest that the same SRS entities are released from a variety of tissues and that these acidic lipids may have a wider physiological significance than just anaphylaxis.

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Year:  1979        PMID： 40646      PMCID： PMC2043883          DOI： 10.1111/j.1476-5381.1979.tb08664.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

1.  BIOLOGICALLY ACTIVE PRINCIPLES OCCURRING ON HISTAMINE RELEASE FROM CAT PAW, GUINEA PIG LUNG AND ISOLATED RAT MAST CELLS.

Authors:  ERIK ANGGARD; U BERGQVIST; B HOEGBERG; K JOHANSSON; I L THON; B UVNAES
Journal:  Acta Physiol Scand       Date:  1963 Sep-Oct

2.  The physicochemical characteristics and purification of slow-reacting substance of anaphylaxis.

Authors:  R P Orange; R C Murphy; M L Karnovsky; K F Austen
Journal:  J Immunol       Date:  1973-03       Impact factor: 5.422

3.  Slow-reacting substance of anaphylaxis: purification and characterisation.

Authors:  H R Morris; G W Taylor; P J Piper; P Sirois; J R Tippins
Journal:  FEBS Lett       Date:  1978-03-15       Impact factor: 4.124

4.  Selective inhibitor of slow reacting substance of anaphylaxis.

Authors:  J Augstein; J B Farmer; T B Lee; P Sheard; M L Tattersall
Journal:  Nat New Biol       Date:  1973-10-17

5.  Slow reacting substance as a preformed mediator from human lung.

Authors:  L S Turnbull; D G Jones; A B Kay
Journal:  Immunology       Date:  1976-11       Impact factor: 7.397

6.  Release of slow reacting substance of anaphylaxis (SRS-A) from human leukocytes by the calcium ionophore A23187.

Authors:  M C Conroy; R P Orange; L M Lichtenstein
Journal:  J Immunol       Date:  1976-06       Impact factor: 5.422

7.  The release of prostaglandins and thromboxanes from guinea-pig lung by slow reacting substance of anaphylaxis, and its inhibition.

Authors:  D M Engineer; H R Morris; P J Piper; P Sirois
Journal:  Br J Pharmacol       Date:  1978-10       Impact factor: 8.739

8.  Release of mediators of anaphylaxis: inhibition of prostaglandin synthesis and the modification of release of slow reacting substance of anaphylaxis and histamine.

Authors:  D M Engineer; U Niederhauser; P J Piper; P Sirois
Journal:  Br J Pharmacol       Date:  1978-01       Impact factor: 8.739

9.  Antibodies involved in antigen-induced release of slow reacting substance of anaphylaxis (SRS-A) in the guinea pig and rat.

Authors:  D J Stechschulte; K F Austen; K J Bloch
Journal:  J Exp Med       Date:  1967-01-01       Impact factor: 14.307
  9 in total
  8 in total

1.  A smooth muscle inhibitory material from the bovine retractor penis and rat anococcygeus muscles.

Authors:  J S Gillespie; W Martin
Journal:  J Physiol       Date:  1980-12       Impact factor: 5.182

2.  Some physical and chemical properties of the smooth muscle inhibitory factor in extracts of the bovine retractor penis muscle.

Authors:  J S Gillespie; J C Hunter; W Martin
Journal:  J Physiol       Date:  1981-06       Impact factor: 5.182

3.  The distribution of adrenoceptors and other drug receptors between the two ends of the rat vas deferens as revealed by selective agonists and antagonists.

Authors:  A MacDonald; J C McGrath
Journal:  Br J Pharmacol       Date:  1980       Impact factor: 8.739

4.  Pharmacologic characterization of immune complex induced bronchoconstriction in guinea pigs.

Authors:  Z E Mielens; E W Ferguson; R A Ferrari
Journal:  Agents Actions       Date:  1981-12

5.  Comparative effects of inhaled leukotriene C4, leukotriene D4, and histamine in normal human subjects.

Authors:  N C Barnes; P J Piper; J F Costello
Journal:  Thorax       Date:  1984-07       Impact factor: 9.139

6.  Slow-reacting substances and their formation by a lipoxygenase pathway.

Authors:  P J Piper; M N Samhoun; J R Tippins; H R Morris; G W Taylor
Journal:  Agents Actions       Date:  1980-12

7.  Characterization of slow reacting substances (SRSs) of rat basophilic leukemia (RBL-1) cells: effect of cysteine on SRS profile.

Authors:  D E Sok; J K Pai; V Atrache; C J Sih
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205

8.  Oxidative transformations of arachidonic acid in human dispersed lung cells: disparity between the utilization of endogenous and exogenous substrate.

Authors:  J Harvey; S T Holgate; B J Peters; C Robinson; J R Walker
Journal:  Br J Pharmacol       Date:  1985-10       Impact factor: 8.739
  8 in total

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