Literature DB >> 6109281

Characterization of slow reacting substances (SRSs) of rat basophilic leukemia (RBL-1) cells: effect of cysteine on SRS profile.

D E Sok, J K Pai, V Atrache, C J Sih.   

Abstract

When RBL-1 cells were incubated with L-cysteine (7.5 mM) and the ionophore A23187, the slow reacting substances SRS-GSH and SRS-Cys-Gly were formed. When L-cysteine was omitted in the incubation, SRS-GSH and SRS-Cys were isolated but only a trace amount of SRS-Cys-Gly was detectable. Each of the characterized SRSs was accompanied by an as yet uncharacterized structural isomer showing UV absorption at 278 nm. L-Cysteine and other thiols inhibited an aminopeptidase that transforms the highly bioactive SRS of anaphylaxis (SRS-Cys-Gly) into the less bioactive SRS-Cys. SRS-GSH, SRS-Cys-Gly, and SRS-Cys may be readily distinguished from each other by means of their bioactivities, antagonism by FPL 55712, and relative susceptibilities to the actions of soybean lipoxygenase, microsome-bound leucine aminopeptidase, and gamma-glutamyl transpeptidase.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 6109281      PMCID： PMC350309          DOI： 10.1073/pnas.77.11.6481

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  22 in total

1.  Release of slow reacting substance (SRS) from rat basophilic leukemia (RBL-1) cells.

Authors:  B A Jakschik; A Kulczycki; H H MacDonald; C W Parker
Journal:  J Immunol       Date:  1977-08       Impact factor: 5.422

Review 2.  Slow reacting substance of anaphylaxis.

Authors:  R P Orange; K F Austen
Journal:  Adv Immunol       Date:  1969       Impact factor: 3.543

3.  Inactivation of slow reacting substance of anaphylaxins (SRS-A) by arylsulfatases.

Authors:  R P Orange; R C Murphy; K F Austen
Journal:  J Immunol       Date:  1974-07       Impact factor: 5.422

4.  Characterization of slow reacting substance as a family of thiolipids derived from arachidonic acid.

Authors:  C W Parker; B A Jakschik; M G Huber; S F Falkenhein
Journal:  Biochem Biophys Res Commun       Date:  1979-08-28       Impact factor: 3.575

5.  Inactivation of slow reacting substance of anaphylaxis by human eosinophil arylsulfatase.

Authors:  S I Wasserman; E J Goetzl; K F Austen
Journal:  J Immunol       Date:  1975-02       Impact factor: 5.422

6.  Stimulated production of slow reacting substances by mercaptans from ionophore A 23187-induced mononuclear cells: mercaptan structure-activity studies.

Authors:  M K Bach; J R Brashler
Journal:  Life Sci       Date:  1978-11-20       Impact factor: 5.037

7.  Tissue inactivation of slow reacting substance of anaphylaxis.

Authors:  A B Kay; E M Roberts; D G Jones
Journal:  Immunology       Date:  1976-01       Impact factor: 7.397

8.  The effect of thiols on the immunologic release of slow reacting substance of anaphylaxis. II. Other in vitro and in vivo models.

Authors:  R P Orange; E G Moore
Journal:  J Immunol       Date:  1976-02       Impact factor: 5.422

9.  The effect of thiols on immunologic release of slow reacting substance of anaphylaxis. I. Human lung.

Authors:  R P Orange; P L Chang
Journal:  J Immunol       Date:  1975-10       Impact factor: 5.422

10.  The release of four mediators of immediate hypersensitivity from human leukemic basophils.

Authors:  R A Lewis; E J Goetzl; S I Wasserman; F H Valone; R H Rubin; K F Austen
Journal:  J Immunol       Date:  1975-01       Impact factor: 5.422
View more
  13 in total

1.  The role of platelet-activating factor and peptidoleukotrienes in the vascular changes of rat passive anaphylaxis.

Authors:  S Fernández-Gallardo; M A Gijón; C García; V Furio; F T Liu; M Sánchez Crespo
Journal:  Br J Pharmacol       Date:  1992-01       Impact factor: 8.739

2.  Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma.

Authors:  A S Cowburn; K Sladek; J Soja; L Adamek; E Nizankowska; A Szczeklik; B K Lam; J F Penrose; F K Austen; S T Holgate; A P Sampson
Journal:  J Clin Invest       Date:  1998-02-15       Impact factor: 14.808

3.  Metabolism of leukotrienes by L-gamma-glutamyl-transpeptidase and dipeptidase from human polymorphonuclear granulocytes.

Authors:  M Raulf; M Stüning; W König
Journal:  Immunology       Date:  1985-05       Impact factor: 7.397

4.  Bioconversion of C-6 sulfidopeptide leukotrienes by the responding guinea pig ileum determines the time course of its contraction.

Authors:  S Krilis; R A Lewis; E J Corey; K F Austen
Journal:  J Clin Invest       Date:  1983-04       Impact factor: 14.808

Review 5.  Metabolism of leukotrienes.

Authors:  S Hammarström; L Orning; K Bernström
Journal:  Mol Cell Biochem       Date:  1985-11       Impact factor: 3.396

6.  Characterization of two dipeptidases purified from hepatic schistosome egg granulomas in mice. Leukotriene D4 hydrolases of granulomatous tissue.

Authors:  N Sato; Y Ito; T Iida; K Fukuyama; W L Epstein
Journal:  Biochem J       Date:  1992-06-15       Impact factor: 3.857

7.  Formation of 11-trans slow reacting substances.

Authors:  V Atrache; D E Sok; J K Pai; C J Sih
Journal:  Proc Natl Acad Sci U S A       Date:  1981-03       Impact factor: 11.205

8.  Conversion of leukotriene D4 to leukotriene E4 by a dipeptidase released from the specific granule of human polymorphonuclear leucocytes.

Authors:  C W Lee; R A Lewis; E J Corey; K F Austen
Journal:  Immunology       Date:  1983-01       Impact factor: 7.397

9.  Leukotriene C promotes prostacyclin synthesis by human endothelial cells.

Authors:  E B Cramer; L Pologe; N A Pawlowski; Z A Cohn; W A Scott
Journal:  Proc Natl Acad Sci U S A       Date:  1983-07       Impact factor: 11.205

10.  Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response.

Authors:  S E Dahlén; J Björk; P Hedqvist; K E Arfors; S Hammarström; J A Lindgren; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.