Literature DB >> 4055089

The production and biological distribution of yttrium-90 labelled antibodies.

A T Vaughan, A Keeling, S C Yankuba.   

Abstract

An antibody has been labelled with generator produced yttrium-90 (90Y) via a chelating group (DTPA) covalently attached to the protein. An average yield for protein labelling of 76% was obtained. The blood clearance of iodinated and 90Y labelled antibody is similar in rats and mice. However, in contrast to iodine, the yttrium label accumulates in the liver after release from the protein.

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Year:  1985        PMID： 4055089     DOI： 10.1016/0020-708x(85)90031-6

Source DB:  PubMed          Journal:  Int J Appl Radiat Isot        ISSN： 0020-708X


  4 in total

Review 1.  Approaches to radiolabeling of antibodies for diagnosis and therapy of cancer.

Authors:  A R Fritzberg; R W Berninger; S W Hadley; D W Wester
Journal:  Pharm Res       Date:  1988-06       Impact factor: 4.200

2.  Labelling monoclonal antibodies with yttrium-90.

Authors:  S J Mather; D M Tolley; G W White
Journal:  Eur J Nucl Med       Date:  1989

3.  Macrocyclic chelates of radiometals for diagnosis and therapy.

Authors:  C F Meares; M K Moi; H Diril; D L Kukis; M J McCall; S V Deshpande; S J DeNardo; D Snook; A A Epenetos
Journal:  Br J Cancer Suppl       Date:  1990-07

4.  Yttrium-90-EDTMP: a radiotherapeutic agent in the treatment of leukaemias.

Authors:  A A Keeling; A T Vaughan; R P Beaney
Journal:  Br J Cancer       Date:  1989-07       Impact factor: 7.640
  4 in total

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