Literature DB >> 3072555

Approaches to radiolabeling of antibodies for diagnosis and therapy of cancer.

A R Fritzberg1, R W Berninger, S W Hadley, D W Wester.   

Abstract

The development of monoclonal antibodies of high affinity and selectivity for tumor antigens has supported the development of radiolabeled antibodies for diagnostic localization and targeted delivery of therapeutic radionuclides. Several radionuclide chelating agent systems have been developed for indium-111 and technetium-99m that have shown good sensitivity and specificity for tumor detection in patients. Feasibility for therapy has been shown in animal models and a few patient studies with iodine-131 and yttrium-90. This review covers selection of radionuclides and chemistry of antibody radiolabeling.

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Year:  1988        PMID： 3072555     DOI： 10.1023/a:1015995208444

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  63 in total

1.  The attachment of metal-chelating groups to protein: tagging of albumin by diazonium coupling and use of the products as radiopharmaceuticals.

Authors:  C S Leung; C F Meares; D A Goodwin
Journal:  Int J Appl Radiat Isot       Date:  1978-11

2.  Studies directed toward the use of antibodies as carriers of radioactivity for therapy.

Authors:  W F BALE; I L SPAR
Journal:  Adv Biol Med Phys       Date:  1957

3.  Complete tumor ablation with iodine 131-radiolabeled disialoganglioside GD2-specific monoclonal antibody against human neuroblastoma xenografted in nude mice.

Authors:  N K Cheung; B Landmeier; J Neely; A D Nelson; C Abramowsky; S Ellery; R B Adams; F Miraldi
Journal:  J Natl Cancer Inst       Date:  1986-09       Impact factor: 13.506

Review 4.  Radiobiologic implications of the microscopic distribution of energy from radionuclides.

Authors:  S J Adelstein; A I Kassis
Journal:  Int J Rad Appl Instrum B       Date:  1987

5.  An efficient method for labelling antibodies with 111In.

Authors:  R G Buckley; F Searle
Journal:  FEBS Lett       Date:  1984-01-23       Impact factor: 4.124

6.  The production and biological distribution of yttrium-90 labelled antibodies.

Authors:  A T Vaughan; A Keeling; S C Yankuba
Journal:  Int J Appl Radiat Isot       Date:  1985-10

7.  Characterization of bromine-77-labeled proteins prepared using bromoperoxidase.

Authors:  K D McElvany; M J Welch
Journal:  J Nucl Med       Date:  1980-10       Impact factor: 10.057

Review 8.  Radioimmunodetection and radioimmunotherapy.

Authors:  S M Larson; J A Carrasquillo; J C Reynolds
Journal:  Cancer Invest       Date:  1984       Impact factor: 2.176

9.  Covalent attachment of metal chelates to proteins:the stability in vivo and in vitro of the conjugate of albumin with a chelate of 111indium.

Authors:  C F Meares; D A Goodwin; C S Leung; A Y Girgis; D J Silvester; A D Nunn; P J Lavender
Journal:  Proc Natl Acad Sci U S A       Date:  1976-11       Impact factor: 11.205

10.  The preparation and labeling of DTPA-coupled albumin.

Authors:  D J Hnatowich; W W Layne; R L Childs
Journal:  Int J Appl Radiat Isot       Date:  1982-05
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  5 in total

Review 1.  Labeling biomolecules with radiorhenium: a review of the bifunctional chelators.

Authors:  Guozheng Liu; Donald J Hnatowich
Journal:  Anticancer Agents Med Chem       Date:  2007-05       Impact factor: 2.505

2.  Rhenium-188 hydroxyethylidene diphosphonate: a new generator-produced radiotherapeutic drug of potential value for the treatment of bone metastases.

Authors:  W Y Lin; C P Lin; S J Yeh; B T Hsieh; Z T Tsai; G Ting; T C Yen; S J Wang; F F Knapp; M G Stabin
Journal:  Eur J Nucl Med       Date:  1997-06

Review 3.  Problems of delivery of monoclonal antibodies. Pharmaceutical and pharmacokinetic solutions.

Authors:  R M Reilly; J Sandhu; T M Alvarez-Diez; S Gallinger; J Kirsh; H Stern
Journal:  Clin Pharmacokinet       Date:  1995-02       Impact factor: 6.447

Review 4.  Radiolabeling with technetium-99m to study high-capacity and low-capacity biochemical systems.

Authors:  W C Eckelman
Journal:  Eur J Nucl Med       Date:  1995-03

5.  The Preparation, Biodistribution, and Dosimetry of Encapsulated Radio-Scandium in a Dendrimer for Radio-nano-pharmaceutical Application.

Authors:  Leila Moghaddam-Banaem; Navideh Aghaei Amirkhizi; Sodeh Sadjadi; Fariba Johari-Deha; Mitra Athari-Allaf
Journal:  Iran J Pharm Res       Date:  2022-05-08       Impact factor: 1.962
  5 in total

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