Literature DB >> 2767080

Labelling monoclonal antibodies with yttrium-90.

S J Mather1, D M Tolley, G W White.   

Abstract

Using the cyclic DTPA derivatisation procedure developed by Hnatowich, conditions have been optimised for labelling three tumour-associated monoclonal antibodies with 90Y. High labelling efficiencies (greater than 95%) at modest specific activities (1 mCi/mg) could be routinely obtained. Radiochemical stability of the radiolabelled preparations in vitro was good, but radiolysis resulted in early losses of antibody immunoreactivity.

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Year:  1989        PMID： 2767080     DOI： 10.1007/BF00435471

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  12 in total

1.  The peptide way to macrocyclic bifunctional chelating agents: synthesis of 2-(p-nitrobenzyl)-1,4,7,10-tetraazacyclododecane-N,N',N",N'''-tetraacetic acid and study of its yttrium(III) complex.

Authors:  M K Moi; C F Meares; S J Denardo
Journal:  J Am Chem Soc       Date:  1988-08-01       Impact factor: 15.419

2.  Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin.

Authors:  J Burchell; S Gendler; J Taylor-Papadimitriou; A Girling; A Lewis; R Millis; D Lamport
Journal:  Cancer Res       Date:  1987-10-15       Impact factor: 12.701

3.  Characterization and chromosomal assignment of a human cell surface antigen defined by the monoclonal antibody AUAI.

Authors:  N K Spurr; H Durbin; D Sheer; M Parkar; L Bobrow; W F Bodmer
Journal:  Int J Cancer       Date:  1986-11-15       Impact factor: 7.396

4.  Determination of the true immunoreactive fraction of monoclonal antibodies after radiolabeling.

Authors:  T Lindmo; P A Bunn
Journal:  Methods Enzymol       Date:  1986       Impact factor: 1.600

5.  Preparation and characterization of monoclonal antibodies against placental alkaline phosphatase and other human trophoblast-associated determinants.

Authors:  P Travers; W Bodmer
Journal:  Int J Cancer       Date:  1984-05-15       Impact factor: 7.396

6.  Radionuclide selection and model absorbed dose calculations for radiolabeled tumor associated antibodies.

Authors:  B W Wessels; R D Rogus
Journal:  Med Phys       Date:  1984 Sep-Oct       Impact factor: 4.071

7.  The production and biological distribution of yttrium-90 labelled antibodies.

Authors:  A T Vaughan; A Keeling; S C Yankuba
Journal:  Int J Appl Radiat Isot       Date:  1985-10

8.  Monoclonal antibodies to epithelium-specific components of the human milk fat globule membrane: production and reaction with cells in culture.

Authors:  J Taylor-Papadimitriou; J A Peterson; J Arklie; J Burchell; R L Ceriani; W F Bodmer
Journal:  Int J Cancer       Date:  1981-07-15       Impact factor: 7.396

9.  90Y-labeled monoclonal antibodies for cancer therapy.

Authors:  L C Washburn; T T Hwa Sun; J E Crook; B L Byrd; J E Carlton; Y W Hung; Z S Steplewski
Journal:  Int J Rad Appl Instrum B       Date:  1986

10.  Patient biodistribution of intraperitoneally administered yttrium-90-labeled antibody.

Authors:  D J Hnatowich; M Chinol; D A Siebecker; M Gionet; T Griffin; P W Doherty; R Hunter; K R Kase
Journal:  J Nucl Med       Date:  1988-08       Impact factor: 10.057
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  3 in total

Review 1.  Radiopharmaceuticals: state of the art.

Authors:  A M Verbruggen
Journal:  Eur J Nucl Med       Date:  1990

2.  Correlation of beta-camera imaging and immunohistochemistry in radioimmunotherapy using 90Y-labeled monoclonal antibodies in ovarian cancer animal models.

Authors:  K J Kairemo; K Ljunggren; T Wahlström; T Stigbrand; S E Strand
Journal:  Cell Biophys       Date:  1994

3.  (111)Indium Labelling of Recombinant Activated Coagulation Factor VII: In Vitro and Preliminary In Vivo Studies in Healthy Rats.

Authors:  Amarnadh Nalla; Inge Buch; Maibritt Sigvardt; Rasmus Poul Bodholdt; Andreas Kjaer; Birger Hesse
Journal:  Int J Mol Imaging       Date:  2012-02-12
  3 in total

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