Literature DB >> 4054594

A chi-square test to distinguish allelic association from other causes of phenotypic association between two loci.

J Ott.   

Abstract

In unrelated individuals, their phenotypes at two gene loci may appear correlated. The two major reasons for such a deviation from independence are linkage disequilibrium (allelic association) and an interaction between the phenotypes. In this paper, it is shown how the usual chi-square test for association of phenotypes can be partitioned into two components, one being due to allelic association and the other being due to other causes of phenotypic association. The test is demonstrated with an example.

Mesh：

Year:  1985        PMID： 4054594     DOI： 10.1002/gepi.1370020108

Source DB:  PubMed          Journal:  Genet Epidemiol        ISSN： 0741-0395            Impact factor:   2.135


  14 in total

1.  A genome screen of multiplex sibships with prostate cancer.

Authors:  B K Suarez; J Lin; J K Burmester; K W Broman; J L Weber; T K Banerjee; K A Goddard; J S Witte; R C Elston; W J Catalona
Journal:  Am J Hum Genet       Date:  2000-03       Impact factor: 11.025

2.  Using denaturing HPLC for SNP discovery and genotyping, and establishing the linkage disequilibrium pattern for the all-trans-retinol dehydrogenase (RDH8) gene.

Authors:  Wei Han; Shea Ping Yip; Jing Wang; Maurice K H Yap
Journal:  J Hum Genet       Date:  2003-12-06       Impact factor: 3.172

3.  Detecting coevolution through allelic association between physically unlinked loci.

Authors:  Rori V Rohlfs; Willie J Swanson; Bruce S Weir
Journal:  Am J Hum Genet       Date:  2010-04-08       Impact factor: 11.025

4.  Two microsatellite polymorphisms at the D5S39 locus.

Authors:  B S Mankoo; R Sherrington; A De La Concha; G Kalsi; D Curtis; G Melmer; H M Gurling
Journal:  Nucleic Acids Res       Date:  1991-04-25       Impact factor: 16.971

5.  Linkage disequilibrium between two highly polymorphic microsatellites.

Authors:  R Sherrington; G Melmer; M Dixon; D Curtis; B Mankoo; G Kalsi; H Gurling
Journal:  Am J Hum Genet       Date:  1991-11       Impact factor: 11.025

6.  A BAM HI RFLP at the human tyrosine aminotransferase (TAT) gene locus at 16q.

Authors:  B Wullich; E Natt; T F Wienker; G Scherer
Journal:  Nucleic Acids Res       Date:  1989-04-25       Impact factor: 16.971

7.  Hot spot of recombination within DXS164 in the Duchenne muscular dystrophy gene.

Authors:  T Grimm; B Müller; M Dreier; E Kind; T Bettecken; G Meng; C R Müller
Journal:  Am J Hum Genet       Date:  1989-09       Impact factor: 11.025

8.  Parathyroid hormone gene analysis in autosomal hypoparathyroidism using an intragenic tetranucleotide (AAAT)n polymorphism.

Authors:  D B Parkinson; N J Shaw; R L Himsworth; R V Thakker
Journal:  Hum Genet       Date:  1993-04       Impact factor: 4.132

9.  Molecular evaluation of an Alu repeat including a polymorphic variable poly(dA) (AluVpA) in the vitamin D binding protein (DBP) gene.

Authors:  A Braun; R Bichlmaier; B Müller; H Cleve
Journal:  Hum Genet       Date:  1993-01       Impact factor: 4.132

10.  The human tyrosine aminotransferase gene: characterization of restriction fragment length polymorphisms and haplotype analysis in a family with tyrosinemia type II.

Authors:  E M Westphal; E Natt; T Grimm; M Odievre; G Scherer
Journal:  Hum Genet       Date:  1988-07       Impact factor: 4.132
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