Literature DB >> 2570527

Hot spot of recombination within DXS164 in the Duchenne muscular dystrophy gene.

T Grimm1, B Müller, M Dreier, E Kind, T Bettecken, G Meng, C R Müller.   

Abstract

The DMD gene, which spans more than 2,000 kbp, has been assigned to band Xp21 of the X chromosome. Two subclones (PERT 87-1 and PERT 87-15) of the intragenic locus DXS164 physically are separated by approximately 60 kbp. Linkage studies were done in 49 informative DMD families by using the LINKAGE program. Crossing-over between the loci studied occurred in four families. A recombination rate of 4% (support interval [Zmax-1] 1%-10%), which was 54 (support interval 14-135-fold) times higher than expected, was found with a maximum lod score of 13.50. These data suggest a hot spot for recombination within DXS164.

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Year:  1989        PMID： 2570527      PMCID： PMC1683399     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  22 in total

1.  Linkage studies of X-linked mental retardation: high frequency of recombination in the telomeric region of the human X chromosome (fragile site/linkage/recombination/X chromosome).

Authors:  K E Davies; M G Mattei; J F Mattei; H Veenema; S McGlade; K Harper; N Tommerup; K B Nielsen; M Mikkelsen; P Beighton
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

Review 2.  Duchenne muscular dystrophy: pathogenetic aspects and genetic prevention.

Authors:  H Moser
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

3.  A chi-square test to distinguish allelic association from other causes of phenotypic association between two loci.

Authors:  J Ott
Journal:  Genet Epidemiol       Date:  1985       Impact factor: 2.135

4.  The genetic linkage map of the human X chromosome.

Authors:  D Drayna; R White
Journal:  Science       Date:  1985-11-15       Impact factor: 47.728

5.  Linkage relationship of a cloned DNA sequence on the short arm of the X chromosome to Duchenne muscular dystrophy.

Authors:  J M Murray; K E Davies; P S Harper; L Meredith; C R Mueller; R Williamson
Journal:  Nature       Date:  1982-11-04       Impact factor: 49.962

6.  Easy calculations of lod scores and genetic risks on small computers.

Authors:  G M Lathrop; J M Lalouel
Journal:  Am J Hum Genet       Date:  1984-03       Impact factor: 11.025

7.  A genetic linkage map of five marker loci in and around the Duchenne muscular dystrophy locus.

Authors:  J D Chen; J F Hejtmancik; G Romeo; M Lindlof; C Boehm; C T Caskey; W Kress; K H Fischbeck; M Dreier; S Serravalle
Journal:  Genomics       Date:  1989-01       Impact factor: 5.736

8.  Multipoint linkage analysis of the short arm of the human X chromosome in families with X-linked muscular dystrophy.

Authors:  D E Wilcox; N A Affara; J R Yates; M A Ferguson-Smith; P L Pearson
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

9.  Prenatal diagnosis and carrier detection of Duchenne muscular dystrophy with closely linked RFLPs.

Authors:  E Bakker; M H Hofker; N Goor; J L Mandel; K Wrogemann; K E Davies; L M Kunkel; H F Willard; W A Fenton; L Sandkuyl
Journal:  Lancet       Date:  1985-03-23       Impact factor: 79.321

10.  Cytological mapping of the human glucose-6-phosphate dehydrogenase gene distal to the fragile-X site suggests a high rate of meiotic recombination across this site.

Authors:  P Szabo; M Purrello; M Rocchi; N Archidiacono; B Alhadeff; G Filippi; D Toniolo; G Martini; L Luzzatto; M Siniscalco
Journal:  Proc Natl Acad Sci U S A       Date:  1984-12       Impact factor: 11.205
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  14 in total

Review 1.  Hot and cold spots of recombination in the human genome: the reason we should find them and how this can be achieved.

Authors:  Norman Arnheim; Peter Calabrese; Magnus Nordborg
Journal:  Am J Hum Genet       Date:  2003-05-22       Impact factor: 11.025

2.  Multiple sites of crossing over within the Eb recombinational hotspot in the mouse.

Authors:  E C Bryda; J A DePari; D B Sant'Angelo; D B Murphy; H C Passmore
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

3.  High-resolution patterns of meiotic recombination across the human major histocompatibility complex.

Authors:  Michael Cullen; Stephen P Perfetto; William Klitz; George Nelson; Mary Carrington
Journal:  Am J Hum Genet       Date:  2002-09-23       Impact factor: 11.025

4.  Nonradioactive assay for new microsatellite polymorphisms at the 5' end of the dystrophin gene, and estimation of intragenic recombination.

Authors:  C Oudet; R Heilig; A Hanauer; J L Mandel
Journal:  Am J Hum Genet       Date:  1991-08       Impact factor: 11.025

5.  Pollen fertility restoration by nuclear gene Fr in CMS common bean: an Fr linkage map and the mode of Fr action.

Authors:  S He; Z H Yu; C E Vallejos; S A Mackenzie
Journal:  Theor Appl Genet       Date:  1995-06       Impact factor: 5.699

6.  Two step procedure for early diagnosis of polycystic kidney disease with polymorphic DNA markers on both sides of the gene.

Authors:  M H Breuning; F G Snijdewint; J G Dauwerse; J J Saris; E Bakker; P L Pearson; G J vanOmmen
Journal:  J Med Genet       Date:  1990-10       Impact factor: 6.318

7.  Characterization of recombination in the HLA class II region.

Authors:  M Cullen; J Noble; H Erlich; K Thorpe; S Beck; W Klitz; J Trowsdale; M Carrington
Journal:  Am J Hum Genet       Date:  1997-02       Impact factor: 11.025

8.  Molecular mapping of a recombination hotspot located in the second intron of the human TAP2 locus.

Authors:  M Cullen; H Erlich; W Klitz; M Carrington
Journal:  Am J Hum Genet       Date:  1995-06       Impact factor: 11.025

9.  Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region.

Authors:  L B Jorde; W S Watkins; M Carlson; J Groden; H Albertsen; A Thliveris; M Leppert
Journal:  Am J Hum Genet       Date:  1994-05       Impact factor: 11.025

10.  Heterogeneity in rates of recombination across the mouse genome.

Authors:  M W Nachman; G A Churchill
Journal:  Genetics       Date:  1996-02       Impact factor: 4.562
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