Literature DB >> 4047495

Lesions of the locus coeruleus system aggravate ischemic damage in the rat brain.

P Blomqvist, O Lindvall, T Wieloch.   

Abstract

The possibility that the noradrenergic locus coeruleus system influences brain damage following ischemia was explored in rats. Bilateral lesions of the locus coeruleus projections to the forebrain aggravated the neuronal necrosis in the hippocampal CA1 region and neocortex following complete cerebral ischemia induced by transient cardiac arrest. These findings provide evidence that the postischemic activation of the inhibitory locus coeruleus system could counteract a possible detrimental neuronal hyperexcitation, thereby limiting neuronal necrosis.

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Year:  1985        PMID： 4047495     DOI： 10.1016/0304-3940(85)90080-1

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  12 in total

1.  Neuronal damage in the striatum following forebrain ischemia: lack of effect of selective lesions of mesostriatal dopamine neurons.

Authors:  T Wieloch; Y Miyauchi; O Lindvall
Journal:  Exp Brain Res       Date:  1990       Impact factor: 1.972

Review 2.  Brain injury: new insights into neurotransmitter and receptor mechanisms.

Authors:  H M Pappius
Journal:  Neurochem Res       Date:  1991-09       Impact factor: 3.996

3.  Mechanisms of epileptic brain damage: evidence for a protective role of the noradrenergic locus coeruleus system in the rat.

Authors:  G Nevander; M Ingvar; O Lindvall
Journal:  Exp Brain Res       Date:  1986       Impact factor: 1.972

4.  Extracellular brain cortical levels of noradrenaline in ischemia: effects of desipramine and postischemic administration of idazoxan.

Authors:  I Gustafson; E J Westerberg; T Wieloch
Journal:  Exp Brain Res       Date:  1991       Impact factor: 1.972

Review 5.  The parasympathetic nervous system in the quest for stroke therapeutics.

Authors:  Cletus Cheyuo; Asha Jacob; Rongqian Wu; Mian Zhou; Gene F Coppa; Ping Wang
Journal:  J Cereb Blood Flow Metab       Date:  2011-03-02       Impact factor: 6.200

6.  Alpha-methyl-para-tyrosine pretreatment protects from striatal neuronal death induced by four-vessel occlusion in the rat.

Authors:  C Marie; C Mossiat; A Beley; J Bralet
Journal:  Neurochem Res       Date:  1992-10       Impact factor: 3.996

7.  Mechanisms of hypoglycemic brain damage. Evidence against a significant role of the noradrenergic locus coeruleus system.

Authors:  O Lindvall; R N Auer; B K Siesjö
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972

8.  Hypothyroidism-evoked shifts in hippocampal adrenergic receptors: implications to ischemia-induced hippocampal damage.

Authors:  S J Hemmings; A Shuaib
Journal:  Mol Cell Biochem       Date:  1998-08       Impact factor: 3.396

9.  Distribution of ischemic neuronal damage in the dorsal hippocampus of rat.

Authors:  R Schmidt-Kastner; K A Hossmann
Journal:  Acta Neuropathol       Date:  1988       Impact factor: 17.088

10.  Selective lesions of mesostriatal dopamine neurons ameliorate hypoglycemic damage in the caudate-putamen.

Authors:  O Lindvall; R N Auer; B K Siesjö
Journal:  Exp Brain Res       Date:  1986       Impact factor: 1.972
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