Literature DB >> 3758254

Selective lesions of mesostriatal dopamine neurons ameliorate hypoglycemic damage in the caudate-putamen.

O Lindvall, R N Auer, B K Siesjö.   

Abstract

Unilateral 6-hydroxydopamine lesion of the mesostriatal dopaminergic system was found to ameliorate neuronal necrosis in the caudate-putamen following 30 min of insulin-induced hypoglycemic coma. We propose that increased release of dopamine in the striatum during hypoglycemia or in the recovery period potentiates a deleterious neuronal hyperexcitation, probably induced by excessive release of glutamate or related compounds, thereby aggravating neuronal necrosis.

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Year:  1986        PMID： 3758254     DOI： 10.1007/bf00236856

Source DB:  PubMed          Journal:  Exp Brain Res        ISSN： 0014-4819            Impact factor:   1.972


  20 in total

1.  The effect of pronounced hypoglycemia on monoamine metabolism in rat brain.

Authors:  C D Agardh; A Carlsson; M Linqvist; B K Siesjö
Journal:  Diabetes       Date:  1979-09       Impact factor: 9.461

2.  Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system.

Authors:  U Ungerstedt; G W Arbuthnott
Journal:  Brain Res       Date:  1970-12-18       Impact factor: 3.252

3.  Tyrosine hydroxylase-immunoreactive boutons in synaptic contact with identified striatonigral neurons, with particular reference to dendritic spines.

Authors:  T F Freund; J F Powell; A D Smith
Journal:  Neuroscience       Date:  1984-12       Impact factor: 3.590

4.  Excitatory input from sensory motor cortex to neostriatum and its modification by conditioning stimulation of the substantia nigra.

Authors:  K Hirata; C Y Yim; G J Mogenson
Journal:  Brain Res       Date:  1984-10-29       Impact factor: 3.252

5.  Morphological and physiological properties of neostriatal neurons: an intracellular horseradish peroxidase study in the rat.

Authors:  G A Bishop; H T Chang; S T Kitai
Journal:  Neuroscience       Date:  1982-01       Impact factor: 3.590

6.  Evidence for amelioration of ischaemic neuronal damage in the hippocampal formation by lesions of the perforant path.

Authors:  T Wieloch; O Lindvall; P Blomqvist; F H Gage
Journal:  Neurol Res       Date:  1985-03       Impact factor: 2.448

7.  Lesions of the locus coeruleus system aggravate ischemic damage in the rat brain.

Authors:  P Blomqvist; O Lindvall; T Wieloch
Journal:  Neurosci Lett       Date:  1985-08-05       Impact factor: 3.046

8.  The aluminum-formaldehyde (ALFA) histofluorescence method for improved visualization of catecholamines and indoleamines. I. A detailed account of the methodology for central nervous tissue using paraffin, cryostat or Vibratome sections.

Authors:  I Lorén; A Björklund; B Falck; O Lindvall
Journal:  J Neurosci Methods       Date:  1980-06       Impact factor: 2.390

9.  Chemical and structural analysis of the relation between cortical inputs and tyrosine hydroxylase-containing terminals in rat neostriatum.

Authors:  J J Bouyer; D H Park; T H Joh; V M Pickel
Journal:  Brain Res       Date:  1984-06-08       Impact factor: 3.252

10.  Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist.

Authors:  T Wieloch
Journal:  Science       Date:  1985-11-08       Impact factor: 47.728
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  3 in total

1.  Neuronal damage in the striatum following forebrain ischemia: lack of effect of selective lesions of mesostriatal dopamine neurons.

Authors:  T Wieloch; Y Miyauchi; O Lindvall
Journal:  Exp Brain Res       Date:  1990       Impact factor: 1.972

2.  Mechanisms of hypoglycemic brain damage. Evidence against a significant role of the noradrenergic locus coeruleus system.

Authors:  O Lindvall; R N Auer; B K Siesjö
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972

3.  Blood flow and metabolism in heterotopic cerebellar grafts during hypoglycemia.

Authors:  M Kiessling; G Mies; W Paschen; R Thilmann; M Detmar; K A Hossmann
Journal:  Acta Neuropathol       Date:  1988       Impact factor: 17.088
  3 in total

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