Literature DB >> 3758262

Mechanisms of epileptic brain damage: evidence for a protective role of the noradrenergic locus coeruleus system in the rat.

G Nevander, M Ingvar, O Lindvall.   

Abstract

This study explores the possibility that the noradrenergic locus coeruleus system influences epileptic brain damage. Bilateral 6-hydroxydopamine lesions of the locus coeruleus projection to the forebrain were found to aggravate neuronal necrosis in the neocortex following 60 min of flurothyl-induced status epilepticus. We propose that the activation of the inhibitory locus coeruleus system during status epilepticus counteracts a deleterious neuronal hyperexcitation, probably induced by excessive release of excitatory amino acids, thereby limiting neuronal necrosis.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3758262     DOI： 10.1007/bf00236864

Source DB:  PubMed          Journal:  Exp Brain Res        ISSN： 0014-4819            Impact factor:   1.972


  24 in total

Review 1.  Nucleus locus ceruleus: new evidence of anatomical and physiological specificity.

Authors:  S L Foote; F E Bloom; G Aston-Jones
Journal:  Physiol Rev       Date:  1983-07       Impact factor: 37.312

2.  Alterations of the cortical noradrenergic system in chronic cobalt epileptogenic foci in the rat: a histofluorescent and biochemical study.

Authors:  S Trottier; B Berger; P Chauvel; J Dedek; M Gay
Journal:  Neuroscience       Date:  1981       Impact factor: 3.590

3.  Status epilepticus in well-oxygenated rats causes neuronal necrosis.

Authors:  G Nevander; M Ingvar; R Auer; B K Siesjö
Journal:  Ann Neurol       Date:  1985-09       Impact factor: 10.422

4.  Evidence for amelioration of ischaemic neuronal damage in the hippocampal formation by lesions of the perforant path.

Authors:  T Wieloch; O Lindvall; P Blomqvist; F H Gage
Journal:  Neurol Res       Date:  1985-03       Impact factor: 2.448

5.  Lesions of the locus coeruleus system aggravate ischemic damage in the rat brain.

Authors:  P Blomqvist; O Lindvall; T Wieloch
Journal:  Neurosci Lett       Date:  1985-08-05       Impact factor: 3.046

6.  Functional activity of substantia nigra grafts reinnervating the striatum: neurotransmitter metabolism and [14C]2-deoxy-D-glucose autoradiography.

Authors:  R H Schmidt; M Ingvar; O Lindvall; U Stenevi; A Björklund
Journal:  J Neurochem       Date:  1982-03       Impact factor: 5.372

7.  Pathogenesis of brain lesions caused by experimental epilepsy. Light- and electron-microscopic changes in the rat cerebral cortex following bicuculline-induced status epilepticus.

Authors:  B Söderfeldt; H Kalimo; Y Olsson; B Siesjö
Journal:  Acta Neuropathol       Date:  1981       Impact factor: 17.088

8.  Role of forebrain catecholamines in amygdaloid kindling.

Authors:  M E Corcoran; S T Mason
Journal:  Brain Res       Date:  1980-05-26       Impact factor: 3.252

9.  Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain.

Authors:  R P Simon; J H Swan; T Griffiths; B S Meldrum
Journal:  Science       Date:  1984-11-16       Impact factor: 47.728

10.  Synaptic activity mediates death of hypoxic neurons.

Authors:  S M Rothman
Journal:  Science       Date:  1983-04-29       Impact factor: 47.728
View more
  6 in total

1.  Emulation of seizure induced brain damage in neural tissue transplants to the anterior chamber of the eye.

Authors:  M Ingvar; M Eriksdotter-Nilsson; A Henschen; L Olson
Journal:  Exp Brain Res       Date:  1990       Impact factor: 1.972

2.  Extracellular brain cortical levels of noradrenaline in ischemia: effects of desipramine and postischemic administration of idazoxan.

Authors:  I Gustafson; E J Westerberg; T Wieloch
Journal:  Exp Brain Res       Date:  1991       Impact factor: 1.972

3.  Immunization of rats with conjugates of dopamine and serotonin with bovine serum albumin prevents the development of experimental MPTP-induced depressive syndrome (electrophysiological parameters).

Authors:  N B Pankova; L A Vetrilé; L A Basharova; N A Krupina; N N Khlebnikova; V I Rodina; G N Kryzhanovskii
Journal:  Neurosci Behav Physiol       Date:  2004-02

4.  Mechanisms of hypoglycemic brain damage. Evidence against a significant role of the noradrenergic locus coeruleus system.

Authors:  O Lindvall; R N Auer; B K Siesjö
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972

5.  Sustained seizures cause circumscribed cerebral changes in glial fibrillary acidic protein, neurofilament and laminin immunofluorescence.

Authors:  M Eriksdotter-Nilsson; H Björklund; D Dahl; L Olson; M Ingvar
Journal:  Exp Brain Res       Date:  1987       Impact factor: 1.972

6.  Selective lesions of mesostriatal dopamine neurons ameliorate hypoglycemic damage in the caudate-putamen.

Authors:  O Lindvall; R N Auer; B K Siesjö
Journal:  Exp Brain Res       Date:  1986       Impact factor: 1.972
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.