Literature DB >> 4044040

Expression of the cloned toxic shock syndrome toxin 1 gene (tst) in vivo with a rabbit uterine model.

J C de Azavedo, T J Foster, P J Hartigan, J P Arbuthnott, M O'Reilly, B N Kreiswirth, R P Novick.   

Abstract

Toxic shock syndrome (TSS) toxin 1 (TSST1) is produced by strains of Staphylococcus aureus associated with TSS. Purified TSST1 induces in rabbits a shock-like illness with many features similar to TSS in humans. These symptoms were also induced by TSST1-producing bacteria in diffusion chambers implanted in the rabbit uterus. Naturally occurring TSST1+ strains and a TSST1- strain harboring a pE194-derived plasmid carrying the cloned TSST1 determinant tst gave the same symptoms. TSST1- strains and a TSST1- strain carrying a pE194-tst plasmid with a deletion of the tst gene had no effect in rabbits. The results with the plasmid-carrying TSST1+ and TSST1- strains, which were isogenic apart from tst, show that the toxin is responsible for the illness in rabbits and suggest that it is a major factor in the pathogenesis of TSS.

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Year:  1985        PMID： 4044040      PMCID： PMC262172          DOI： 10.1128/iai.50.1.304-309.1985

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  35 in total

1.  Properties of a supercoiled deoxyribonucleic acid-protein relaxation complex and strand specificity of the relaxation event.

Authors:  D B Clewell; D R Helinski
Journal:  Biochemistry       Date:  1970-10-27       Impact factor: 3.162

2.  The problems of drug-resistant pathogenic bacteria. Extrachromosomal nature of drug resistance in Staphylococcus aureus.

Authors:  R P Novick; D Bouanchaud
Journal:  Ann N Y Acad Sci       Date:  1971-06-11       Impact factor: 5.691

3.  Immunization, isolation of immunoglobulins, estimation of antibody titre.

Authors:  N Harboe; A Ingild
Journal:  Scand J Immunol Suppl       Date:  1973

4.  Incompatibility and molecular relationships between small Staphylococcal plasmids carrying the same resistance marker.

Authors:  S Iordanescu; M Surdeanu; P Della Latta; R Novick
Journal:  Plasmid       Date:  1978-09       Impact factor: 3.466

5.  Characterization of chimeric plasmid cloning vehicles in Bacillus subtilis.

Authors:  T Gryczan; A G Shivakumar; D Dubnau
Journal:  J Bacteriol       Date:  1980-01       Impact factor: 3.490

6.  High frequency transformation of Bacillus subtilis protoplasts by plasmid DNA.

Authors:  S Chang; S N Cohen
Journal:  Mol Gen Genet       Date:  1979-01-05

7.  Qualitative and quantitative methods for detecting staphylococcal epidermolytic toxin.

Authors:  J P Arbuthnott; B Billcliffe
Journal:  J Med Microbiol       Date:  1976-05       Impact factor: 2.472

8.  Construction and characterization of new cloning vehicles. I. Ampicillin-resistant derivatives of the plasmid pMB9.

Authors:  F Bolivar; R L Rodriguez; M C Betlach; H W Boyer
Journal:  Gene       Date:  1977       Impact factor: 3.688

9.  Toxic-shock syndrome: epidemiologic features, recurrence, risk factors, and prevention.

Authors:  J P Davis; P J Chesney; P J Wand; M LaVenture
Journal:  N Engl J Med       Date:  1980-12-18       Impact factor: 91.245

10.  Toxic-shock syndrome associated with phage-group-I Staphylococci.

Authors:  J Todd; M Fishaut; F Kapral; T Welch
Journal:  Lancet       Date:  1978-11-25       Impact factor: 79.321
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  33 in total

1.  Residues 20, 22, and 26 determine the subtype specificities of staphylococcal enterotoxins C1 and C2.

Authors:  T N Turner; C L Smith; G A Bohach
Journal:  Infect Immun       Date:  1992-02       Impact factor: 3.441

2.  Structure-function analysis of the SaPIbov1 replication origin in Staphylococcus aureus.

Authors:  Carles Ubeda; María Ángeles Tormo-Más; José R Penadés; Richard P Novick
Journal:  Plasmid       Date:  2012-01-20       Impact factor: 3.466

Review 3.  The potential use of toxin antibodies as a strategy for controlling acute Staphylococcus aureus infections.

Authors:  Gordon Y C Cheung; Michael Otto
Journal:  Expert Opin Ther Targets       Date:  2012-04-25       Impact factor: 6.902

4.  Identification of ligand specificity determinants in AgrC, the Staphylococcus aureus quorum-sensing receptor.

Authors:  Edward Geisinger; Elizabeth A George; John Chen; Tom W Muir; Richard P Novick
Journal:  J Biol Chem       Date:  2008-01-25       Impact factor: 5.157

5.  [IgM antibodies to toxic shock syndrome toxin-1 in human sera and human immunoglobulins].

Authors:  N Dickgiesser; F Düzgün
Journal:  Klin Wochenschr       Date:  1988-01-04

6.  Protection of rabbits in an infection model of toxic shock syndrome (TSS) by a TSS toxin-1-specific monoclonal antibody.

Authors:  G K Best; D F Scott; J M Kling; M R Thompson; L E Adinolfi; P F Bonventre
Journal:  Infect Immun       Date:  1988-04       Impact factor: 3.441

7.  Production of gamma-hemolysin and lack of production of alpha-hemolysin by Staphylococcus aureus strains associated with toxic shock syndrome.

Authors:  M Clyne; J De Azavedo; E Carlson; J Arbuthnott
Journal:  J Clin Microbiol       Date:  1988-03       Impact factor: 5.948

8.  Nucleotide sequence of the staphylococcal enterotoxin C3 gene: sequence comparison of all three type C staphylococcal enterotoxins.

Authors:  C J Hovde; S P Hackett; G A Bohach
Journal:  Mol Gen Genet       Date:  1990-01

9.  [IgG antibodies to toxic shock syndrome toxin-1 (TSST-1) in human sera].

Authors:  N Dickgiesser; B Kustermann
Journal:  Klin Wochenschr       Date:  1987-03-16

Review 10.  Toxic shock syndrome.

Authors:  J K Todd
Journal:  Clin Microbiol Rev       Date:  1988-10       Impact factor: 26.132
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