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Literature DB >> 4020621

Pharmacokinetics of theobromine and its metabolites in rabbits.

Abstract

The pharmacokinetics of theobromine (3, 7-DMX) and its metabolites was investigated in detail in four male rabbits after bolus intravenous injection (4 mg/kg) of the compound. Apparent first-order rate constants for the metabolic processes involved in the formation of 3,7-DMX metabolites and their excretion in urine were calculated. Theobromine, 7-methylxanthine (7-MX) and 3-methylxanthine (3-MX) were measured in blood and urine, and the other metabolites were determined only in urine. An appropriate model of 14 compartments is formulated to describe the disposition of 3,7-DMX and its metabolites.

Entities: Chemical Species

Mesh：

Substances：
Theobromine

Year: 1985 PMID： 4020621 DOI： 10.1007/bf01073655

Source DB: PubMed Journal: J Pharmacokinet Biopharm ISSN： 0090-466X

15 in total

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Journal: Toxicology Date: 1984-04-16 Impact factor: 4.221

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Authors: S M Tarka; M J Arnaud; B H Dvorchik; E S Vesell
Journal: Clin Pharmacol Ther Date: 1983-10 Impact factor: 6.875

9. Kinetics and metabolism of theobromine in male and female non-pregnant and pregnant rabbits.

Authors: R Latini; M Bonati; F Gaspari; G L Traina; L Jiritano; A Bortolotti; J F Borzelleca; S M Tarka; M J Arnaud; S Garattini
Journal: Toxicology Date: 1984-04-16 Impact factor: 4.221

10. [2-14C]caffeine metabolism in control and 3-methylcholanthrene induced rat liver microsomes by high pressure liquid chromatography.

Authors: M Bonati; R Latini; E Marzi; R Cantoni; G Belvedere
Journal: Toxicol Lett Date: 1980-11 Impact factor: 4.372

3 in total