Literature DB >> 3830715

Pharmacokinetics of theophylline and its metabolites in rabbits.

A Celardo, G L Traina, A Jankowski, M Bonati.   

Abstract

The pharmacokinetics of theophylline (1,3-DMX) and its metabolites were investigated in detail in four male rabbits after bolus intravenous injection (12 mg/kg) of the compound. Theophylline was measured in blood and urine, and its metabolites were determined only in urine. Apparent first-order rate constants for the metabolic processes involved in the formation of 1,3-DMX metabolites and their excretion in urine were calculated. An appropriate 13-compartment model was formulated to describe the disposition of 1,3-DMX and its metabolites.

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Year:  1985        PMID： 3830715     DOI： 10.1007/BF03189755

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  19 in total

1.  NL-FIT: a microcomputer program for non-linear fitting.

Authors:  G S Landriani; V Guardabasso; M Rocchetti
Journal:  Comput Programs Biomed       Date:  1983 Feb-Apr

2.  Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations.

Authors:  K Yamaoka; T Nakagawa; T Uno
Journal:  J Pharmacokinet Biopharm       Date:  1978-04

3.  Method for the rapid estimation of the total body drug clearance and adjustment of dosage regimens in patients during a constant-rate intravenous infusion.

Authors:  W L Chiou; M A Gadalla; G W Peng
Journal:  J Pharmacokinet Biopharm       Date:  1978-04

4.  Measurement of excretion characteristics of theophylline and its major metabolites.

Authors:  J H Jonkman; D Tang; R A Upton; S Riegelman
Journal:  Eur J Clin Pharmacol       Date:  1981       Impact factor: 2.953

5.  Kinetic considerations relating to the accrual and elimination of drug metabolites.

Authors:  A J Cummings; B K Martin; G S Park
Journal:  Br J Pharmacol Chemother       Date:  1967-02

6.  Urinary excretion of methylated purines in man and in the rat after the administration of theophylline.

Authors:  A H van Gennip; J Grift; E J van Bree-Blom; D Ketting; S K Wadman
Journal:  J Chromatogr       Date:  1979-08-21

7.  [2-14C]caffeine metabolism in control and 3-methylcholanthrene induced rat liver microsomes by high pressure liquid chromatography.

Authors:  M Bonati; R Latini; E Marzi; R Cantoni; G Belvedere
Journal:  Toxicol Lett       Date:  1980-11       Impact factor: 4.372

8.  Biodisposition of theophylline. I. Genetic variation in inbred mice.

Authors:  C J Betlach; T N Tozer
Journal:  Drug Metab Dispos       Date:  1980 Jul-Aug       Impact factor: 3.922

9.  Theophylline metabolism during the first month of life and development.

Authors:  M Bonati; R Latini; G Marra; B M Assael; R Parini
Journal:  Pediatr Res       Date:  1981-04       Impact factor: 3.756

10.  Adenosine receptors and behavioral actions of methylxanthines.

Authors:  S H Snyder; J J Katims; Z Annau; R F Bruns; J W Daly
Journal:  Proc Natl Acad Sci U S A       Date:  1981-05       Impact factor: 11.205
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  3 in total

1.  Bioavailability of oral isbufylline in rabbits.

Authors:  A Celardo; G Dell'Elba; M Bonati
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1992 Jan-Mar       Impact factor: 2.441

2.  Sex-related differences in theophylline pharmacokinetics.

Authors:  A N Nafziger; J S Bertino
Journal:  Eur J Clin Pharmacol       Date:  1989       Impact factor: 2.953

3.  Development and validation of a physiology-based model for the prediction of pharmacokinetics/toxicokinetics in rabbits.

Authors:  Panteleimon D Mavroudis; Helen E Hermes; Donato Teutonico; Thomas G Preuss; Sebastian Schneckener
Journal:  PLoS One       Date:  2018-03-21       Impact factor: 3.240
  3 in total

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