Literature DB >> 4009792

Chemotherapy and vaccination: a possible strategy for the control of highly virulent influenza virus.

R G Webster, Y Kawaoka, W J Bean, C W Beard, M Brugh.   

Abstract

The influenza A virus [A/Chicken/Pennsylvania/1370/83 (H5N2)] that caused up to 80% mortality among chickens provided a model system for testing the efficacy of chemotherapeutic agents against highly virulent influenza virus. Amantadine and rimantadine administered in drinking water were efficacious both prophylactically and therapeutically. However, under conditions simulating natural transmission of virus, amantadine- and rimantadine-resistant viruses arose and were transmitted to other birds in contact with the infected chickens, causing mortality. Simultaneous administration of inactivated H5N2 vaccine and amantadine provided protection. Thus, chemotherapy may be useful in the treatment of a highly pathogenic influenza virus outbreak in humans or other animals when used in combination with vaccine.

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Year:  1985        PMID： 4009792      PMCID： PMC254912     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  15 in total

1.  Evaluation of amantadine in artificially induced A2 and B influenza.

Authors:  A A Smorodintsev; D M Zlydnikov; A M Kiseleva; J A Romanov; A P Kazantsev; V I Rumovsky
Journal:  JAMA       Date:  1970-08-31       Impact factor: 56.272

2.  Studies on induced influenza in man. I. Double-blind studies designed to assess prophylactic efficacy of amantadine hydrochloride against a2/Rockville/1/65 strain.

Authors:  Y Togo; R B Hornick; A T Dawkins
Journal:  JAMA       Date:  1968-03-25       Impact factor: 56.272

3.  New antigenic variants of avian influenza A viruses.

Authors:  H G Pereira; G Lang; O M Olesiuk; G H Snoeyenbos; D H Roberts; B C Easterday
Journal:  Bull World Health Organ       Date:  1966       Impact factor: 9.408

4.  In vivo selection of an influenza A2 strain resistant to amantadine.

Authors:  J S Oxford; I S Logan; C W Potter
Journal:  Nature       Date:  1970-04-04       Impact factor: 49.962

5.  Prevention of malignant avian influenza by 1-adamantanamine hydrochloride.

Authors:  G Lang; O Narayan; B T Rouse
Journal:  Arch Gesamte Virusforsch       Date:  1970

6.  Inhibition of uncoating of fowl plague virus by l-adamantanamine hydrochloride.

Authors:  N Kato; H J Eggers
Journal:  Virology       Date:  1969-04       Impact factor: 3.616

7.  Susceptibility of influenza A viruses to amantadine is influenced by the gene coding for M protein.

Authors:  M D Lubeck; J L Schulman; P Palese
Journal:  J Virol       Date:  1978-12       Impact factor: 5.103

8.  Novel influenza A viruses isolated from Canadian feral ducks: including strains antigenically related to swine influenza (Hsw1N1) viruses.

Authors:  V S Hinshaw; R G Webster; B Turner
Journal:  J Gen Virol       Date:  1978-10       Impact factor: 3.891

9.  On the mechanism of inhibition of influenza virus replication by amantadine hydrochloride.

Authors:  J J Skehel; A J Hay; J A Armstrong
Journal:  J Gen Virol       Date:  1978-01       Impact factor: 3.891

10.  Amantadine-resistance as a genetic marker for influenza viruses.

Authors:  G Appleyard
Journal:  J Gen Virol       Date:  1977-08       Impact factor: 3.891
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  12 in total

Review 1.  The influenza pandemic of 2009: lessons and implications.

Authors:  Paul Shapshak; Francesco Chiappelli; Charurut Somboonwit; John Sinnott
Journal:  Mol Diagn Ther       Date:  2011-04-01       Impact factor: 4.074

2.  Genetic basis of resistance to rimantadine emerging during treatment of influenza virus infection.

Authors:  R B Belshe; M H Smith; C B Hall; R Betts; A J Hay
Journal:  J Virol       Date:  1988-05       Impact factor: 5.103

Review 3.  Pandemic threat posed by avian influenza A viruses.

Authors:  T Horimoto; Y Kawaoka
Journal:  Clin Microbiol Rev       Date:  2001-01       Impact factor: 26.132

4.  Utilization of the embryonated egg for in vivo evaluation of the anti-influenza virus activity of neuraminidase inhibitors.

Authors:  A Sauerbrei; A Haertl; A Brandstaedt; M Schmidtke; P Wutzler
Journal:  Med Microbiol Immunol       Date:  2005-07-30       Impact factor: 3.402

5.  Recovery of drug-resistant influenza A virus during therapeutic use of rimantadine.

Authors:  F G Hayden; S J Sperber; R B Belshe; R D Clover; A J Hay; S Pyke
Journal:  Antimicrob Agents Chemother       Date:  1991-09       Impact factor: 5.191

6.  Safety and prophylactic efficacy of low-dose rimantadine in adults during an influenza A epidemic.

Authors:  M T Brady; S D Sears; D L Pacini; R Samorodin; J DePamphilis; M Oakes; W Soo; M L Clements
Journal:  Antimicrob Agents Chemother       Date:  1990-09       Impact factor: 5.191

7.  Relation between drug resistance and antigenicity among norakin-resistant mutants of influenza A (fowl plague) virus.

Authors:  A I Klimov; S G Markushin; S Prösch; V P Ginzburg; H Heider; A M Heider; C Schröeder; R G Webster
Journal:  Arch Virol       Date:  1992       Impact factor: 2.574

8.  A single electroporation delivery of a DNA vaccine containing the hemagglutinin gene of Asian H5N1 avian influenza virus generated a protective antibody response in chickens against a North American virus strain.

Authors:  Oladele Ogunremi; John Pasick; Gary P Kobinger; Drew Hannaman; Yohannes Berhane; Alfonso Clavijo; Sylvia van Drunen Littel-van den Hurk
Journal:  Clin Vaccine Immunol       Date:  2013-01-30

9.  Specific structural alteration of the influenza haemagglutinin by amantadine.

Authors:  R J Sugrue; G Bahadur; M C Zambon; M Hall-Smith; A R Douglas; A J Hay
Journal:  EMBO J       Date:  1990-11       Impact factor: 11.598

Review 10.  Insight into alternative approaches for control of avian influenza in poultry, with emphasis on highly pathogenic H5N1.

Authors:  E M Abdelwhab; Hafez M Hafez
Journal:  Viruses       Date:  2012-11-19       Impact factor: 5.048
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