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Literature DB >> 561163

Amantadine-resistance as a genetic marker for influenza viruses.

Abstract

The infection of eggs, cell cultures or mice with a mixture of amantadine-resistant and amantadine-sensitive strains of influenza virus resulted in the transfer of amantadine-resistance or sensitivity between strains. The response of a recombinant virus to amantadine was not related to either of its surface antigens. Resistance to amantadine was transferred as an all-or-none character. It is concluded that amantadine-resistance is a useful genetic marker for influenza viruses.

Entities: Chemical Species

Mesh：

Substances：
Amantadine

Year: 1977 PMID： 561163 DOI： 10.1099/0022-1317-36-2-249

Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891

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Cited

25 in total

1. Influenza A virus can undergo multiple cycles of replication without M2 ion channel activity.

Authors: T Watanabe; S Watanabe; H Ito; H Kida; Y Kawaoka
Journal: J Virol Date: 2001-06 Impact factor: 5.103

2. Occurrence of mixed populations of influenza A viruses that can be maintained through transmission in a single host and potential for reassortment.

Authors: Yuki Furuse; Akira Suzuki; Makiko Kishi; Nao Nukiwa; Midori Shimizu; Rumi Sawayama; Naoko Fuji; Hitoshi Oshitani
Journal: J Clin Microbiol Date: 2009-11-25 Impact factor: 5.948

Amantadine-resistance as a genetic marker for influenza viruses.

1. Influenza A virus can undergo multiple cycles of replication without M2 ion channel activity.

2. Occurrence of mixed populations of influenza A viruses that can be maintained through transmission in a single host and potential for reassortment.

Review 3. Antiviral agents: action and clinical use.

4. Growth restriction of influenza A virus by M2 protein antibody is genetically linked to the M1 protein.

5. Genetic basis of resistance to rimantadine emerging during treatment of influenza virus infection.

6. Characterization of mutants of influenza A virus selected with the neuraminidase inhibitor 4-guanidino-Neu5Ac2en.

7. Free-energy profiles for ions in the influenza M2-TMD channel.

8. Tromantadine: inhibitor of early and late events in herpes simplex virus replication.

9. The amantadine-sensitivity of recombinant and parental influenza virus strains.

10. Susceptibility of influenza A viruses to amantadine is influenced by the gene coding for M protein.