Literature DB >> 3979007

Reduction of serum theophylline levels by terbutaline in children with asthma.

Y Danziger, M Garty, B Volwitz, D Ilfeld, I Varsano, J B Rosenfeld.   

Abstract

We studied the effect of oral terbutaline on serum theophylline levels in 12 children with asthma. Sustained-release theophylline (10 mg/kg twice a day) was given with placebo or terbutaline (0.075 mg/kg three times a day) in a chronic, randomized, double-blind, crossover design. The trough serum theophylline concentration fell from 13.8 +/- 4.0 to 10.8 +/- 3.6 micrograms/ml and the peak expiratory flow rate increased from 285 +/- 30 to 310 +/- 29 L/min after terbutaline. Further investigation is needed to clarify the mechanism of action by which terbutaline decreases serum theophylline levels.

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Year:  1985        PMID： 3979007     DOI： 10.1038/clpt.1985.73

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  9 in total

Review 1.  Pharmacokinetic interactions between theophylline and other medication (Part II).

Authors:  R A Upton
Journal:  Clin Pharmacokinet       Date:  1991-02       Impact factor: 6.447

2.  Increased theophylline clearance in asthmatic patients due to terbutaline.

Authors:  M Garty; L Paul-Keslin; D N Ilfeld; A Mazar; S Spitzer; J B Rosenfeld
Journal:  Eur J Clin Pharmacol       Date:  1989       Impact factor: 2.953

Review 3.  Influence of endogenous and exogenous effectors on the pharmacokinetics of theophylline. Focus on biotransformation.

Authors:  U Tröger; F P Meyer
Journal:  Clin Pharmacokinet       Date:  1995-04       Impact factor: 6.447

4.  Theophylline-terbutaline, a steady state study on possible pharmacokinetic interactions with special reference to chronopharmacokinetic aspects.

Authors:  J H Jonkman; L Borgström; W J van der Boon; O E de Noord
Journal:  Br J Clin Pharmacol       Date:  1988-09       Impact factor: 4.335

5.  Non-interaction of ketotifen and theophylline in children with asthma--an acute study.

Authors:  M Garty; D Scolnik; Y Danziger; B Volovitz; D N Ilfeld; I Varsano
Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953

6.  Acute effects of short-term subcutaneous terbutaline on theophylline disposition.

Authors:  J Snidow; M Stephens; T Self; C Stewart; L Bobo; J A Pieper
Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953

7.  Bronchodilator effect and serum theophylline level after combined treatment with fenoterol and theophylline in reversible chronic airflow obstruction.

Authors:  M I Lucena; J Almagro; F Rius; F Sanchez de la Cuesta
Journal:  Eur J Clin Pharmacol       Date:  1988       Impact factor: 2.953

Review 8.  Clinical pharmacokinetics of beta-agonists.

Authors:  D J Morgan
Journal:  Clin Pharmacokinet       Date:  1990-04       Impact factor: 6.447

9.  Evaluation of theophylline pharmacokinetics in a pediatric population using mixed effects models.

Authors:  M S Driscoll; T M Ludden; D T Casto; L C Littlefield
Journal:  J Pharmacokinet Biopharm       Date:  1989-04
  9 in total

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