Literature DB >> 3954731

Iron mobilization from ferritin using alpha-oxohydroxy heteroaromatic chelators.

G J Kontoghiorghes.   

Abstract

Several alpha-oxohydroxy heteroaromatic chelators have been shown to mobilize iron from horse spleen ferritin. Although the reactions were slow, taking up to 3 days to reach completion, the amounts of iron mobilized were higher than those reported for other chelators. These results increase the prospects for the clinical use of alpha-oxohydroxy chelators in the treatment of iron overload.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3954731      PMCID： PMC1153022          DOI： 10.1042/bj2330299

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  11 in total

1.  Mobilisation of iron from ferritin fractions of defined iron content by biological reductants.

Authors:  J Dognin; R R Crichton
Journal:  FEBS Lett       Date:  1975-06-15       Impact factor: 4.124

2.  A mechanism for ferritin-iron oxidation and deposition [proceedings].

Authors:  R R Crichton; F Roman
Journal:  Biochem Soc Trans       Date:  1977       Impact factor: 5.407

Review 3.  Ferritin: structure, biosynthesis, and role in iron metabolism.

Authors:  H N Munro; M C Linder
Journal:  Physiol Rev       Date:  1978-04       Impact factor: 37.312

4.  The mobilization of iron from ferritin by chelating agents.

Authors:  L Pape; J S Multani; C Stitt; P Saltman
Journal:  Biochemistry       Date:  1968-02       Impact factor: 3.162

5.  [Syntheses of N-substituted-3-glucosyloxy-2-methyl-4-pyridones and their aglycones].

Authors:  M Yasue; N Kawamura; J Sakakibara
Journal:  Yakugaku Zasshi       Date:  1970-10       Impact factor: 0.302

6.  New orally active iron chelators.

Authors:  G J Kontoghiorghes
Journal:  Lancet       Date:  1985-04-06       Impact factor: 79.321

7.  The release of iron from horse spleen ferritin by reduced flavins.

Authors:  S Sirivech; E Frieden; S Osaki
Journal:  Biochem J       Date:  1974-11       Impact factor: 3.857

8.  Iron mobilization from ferritin by chelating agents.

Authors:  R R Crichton; F Roman; F Roland
Journal:  J Inorg Biochem       Date:  1980-12       Impact factor: 4.155

9.  Ferric ion sequestering agents: kinetics of iron release from ferritin to catechoylamides.

Authors:  T P Tufano; V L Pecoraro; K N Raymond
Journal:  Biochim Biophys Acta       Date:  1981-05-29

10.  The binding of ferric iron by ferritin.

Authors:  A Treffry; P M Harrison
Journal:  Biochem J       Date:  1979-09-01       Impact factor: 3.857
View more
  15 in total

1.  Comparative study of iron mobilization from haemosiderin, ferritin and iron(III) precipitates by chelators.

Authors:  G J Kontoghiorghes; S Chambers; A V Hoffbrand
Journal:  Biochem J       Date:  1987-01-01       Impact factor: 3.857

2.  Effect of chaotropes on the kinetics of iron release from ferritin by flavin nucleotides.

Authors:  Lindsay E Johnson; Tyler Wilkinson; Paolo Arosio; Artem Melman; Fadi Bou-Abdallah
Journal:  Biochim Biophys Acta Gen Subj       Date:  2017-09-21       Impact factor: 3.770

3.  New developments and controversies in iron metabolism and iron chelation therapy.

Authors:  Christina N Kontoghiorghe; George J Kontoghiorghes
Journal:  World J Methodol       Date:  2016-03-26

4.  A new role for heme, facilitating release of iron from the bacterioferritin iron biomineral.

Authors:  Samina Yasmin; Simon C Andrews; Geoffrey R Moore; Nick E Le Brun
Journal:  J Biol Chem       Date:  2010-11-23       Impact factor: 5.157

Review 5.  Transition of Thalassaemia and Friedreich ataxia from fatal to chronic diseases.

Authors:  Annita Kolnagou; Christina N Kontoghiorghe; George J Kontoghiorghes
Journal:  World J Methodol       Date:  2014-12-26

6.  Prooxidant and antioxidant effects of Trolox on ferric ion-induced oxidation of erythrocyte membrane lipids.

Authors:  K M Ko; P K Yick; M K Poon; S P Ip
Journal:  Mol Cell Biochem       Date:  1994-12-07       Impact factor: 3.396

7.  Metal chelators coupled with nanoparticles as potential therapeutic agents for Alzheimer's disease.

Authors:  Gang Liu; Ping Men; George Perry; Mark A Smith
Journal:  J Nanoneurosci       Date:  2009-06-01

8.  Iron chelation studies using desferrioxamine and the potential oral chelator, 1,2-dimethyl-3-hydroxypyrid-4-one, in normal and iron loaded rats.

Authors:  G J Kontoghiorghes; L Sheppard; A V Hoffbrand; J Charalambous; J Tikerpae; M J Pippard
Journal:  J Clin Pathol       Date:  1987-04       Impact factor: 3.411

9.  The removal of metal ions from transferrin, ferritin and ceruloplasmin by the cardioprotective agent ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane] and its hydrolysis product ADR-925.

Authors:  B B Hasinoff; S V Kala
Journal:  Agents Actions       Date:  1993-05

10.  The iron chelators desferrioxamine and 1-alkyl-2-methyl-3-hydroxypyrid-4-ones inhibit vascular prostacyclin synthesis in vitro.

Authors:  J Y Jeremy; G J Kontoghiorghes; A V Hoffbrand; P Dandona
Journal:  Biochem J       Date:  1988-08-15       Impact factor: 3.857
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.