Literature DB >> 3953575

Genetic analysis of thirty-three platelet polypeptides detected in two-dimensional polyacrylamide gels.

S M Hanash, J V Neel, L J Baier, B B Rosenblum, W Niezgoda, D Markel.   

Abstract

Two-dimensional gel electrophoresis followed by silver-staining was utilized to visualize platelet polypeptides for genetic analysis. A subset of 33 polypeptides that were most suited for scoring was selected. Families consisting of father-mother-child trios were studied. Thirty-six polypeptides of a total of 1,413 scored in children's gels exhibited the combination of a normal and a variant polypeptide. The observed index of heterozygosity of 2.55% is comparable to our previously reported findings for red cell proteins.

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Year:  1986        PMID： 3953575      PMCID： PMC1684779     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  18 in total

1.  Identification of genetic variants in erythrocyte lysate by two-dimensional gel electrophoresis.

Authors:  B B Rosenblum; J V Neel; S M Hanash; J L Joseph; N Yew
Journal:  Am J Hum Genet       Date:  1984-05       Impact factor: 11.025

2.  Separation of allelic variants by two-dimensional electrophoresis.

Authors:  L A Wanner; J V Neel; M H Meisler
Journal:  Am J Hum Genet       Date:  1982-03       Impact factor: 11.025

3.  Actin mutations in a human fibroblast model for carcinogenesis.

Authors:  J Leavitt; D Goldman; C Merril; T Kakunaga
Journal:  Clin Chem       Date:  1982-04       Impact factor: 8.327

4.  Genetic analysis of human lymphocyte proteins by two-dimensional gel electrophoresis: 2. Genetic polymorphism of lymphocyte cytosol 64K polypeptide.

Authors:  H Hamaguchi; M Yamada; A Noguchi; K Fujii; M Shibasaki; R Mukai; T Yabe; I Kondo
Journal:  Hum Genet       Date:  1982       Impact factor: 4.132

5.  Genetic analysis of human lymphocyte proteins by two-dimensional gel electrophoresis: 1. Detection of genetic variant polypeptides in PHA-stimulated peripheral blood lymphocytes.

Authors:  H Hamaguchi; A Ohta; R Mukai; T Yabe; M Yamada
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

6.  Genetic analysis of human lymphocyte proteins by two-dimensional gel electrophoresis: 4. Genetic polymorphism of cytosol 100k polypeptide.

Authors:  H Hamaguchi; M Yamada; M Shibasaki; I Kondo
Journal:  Hum Genet       Date:  1982       Impact factor: 4.132

7.  Two-dimensional electrophoresis of plasma polypeptides reveals "high" heterozygosity indices.

Authors:  B B Rosenblum; J V Neel; S M Hanash
Journal:  Proc Natl Acad Sci U S A       Date:  1983-08       Impact factor: 11.205

8.  Human lymphocyte polymorphisms detected by quantitative two-dimensional electrophoresis.

Authors:  D Goldman; C R Merril
Journal:  Am J Hum Genet       Date:  1983-09       Impact factor: 11.025

9.  Human hypoxanthine (guanine) phosphoribosyltransferase: an amino acid substitution in a mutant form of the enzyme isolated from a patient with gout.

Authors:  J M Wilson; G E Tarr; W N Kelley
Journal:  Proc Natl Acad Sci U S A       Date:  1983-02       Impact factor: 11.205

10.  Genetic analysis of human lymphocyte proteins by two-dimensional gel electrophoresis: 3. Frequent occurrence of genetic variants in some abundant polypeptides of PHA-stimulated peripheral blood lymphocytes.

Authors:  H Hamaguchi; M Yamada; M Shibasaki; R Mukai; T Yabe; I Kondo
Journal:  Hum Genet       Date:  1982       Impact factor: 4.132
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  10 in total

Review 1.  Proteomic approaches to dissect platelet function: Half the story.

Authors:  Dmitri V Gnatenko; Peter L Perrotta; Wadie F Bahou
Journal:  Blood       Date:  2006-08-22       Impact factor: 22.113

2.  Average locus differences in mutability related to protein "class": a hypothesis.

Authors:  J V Neel
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

3.  Heterozygosity and ethnic variation in Japanese platelet proteins.

Authors:  J Asakawa; J V Neel; N Takahashi; C Satoh; S Kaneoka; E Nishikori; M Fujita
Journal:  Hum Genet       Date:  1988-01       Impact factor: 4.132

4.  Two-dimensional gel studies of genetic variation in the plasma proteins of Amerindians and Japanese.

Authors:  J Asakawa; N Takahashi; B B Rosenblum; J V Neel
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

5.  Proteomic approach to probe for larval proteins of the mussel Mytilus galloprovincialis.

Authors:  José Luis López; Silvia Lorenzo Abalde; José Fuentes
Journal:  Mar Biotechnol (NY)       Date:  2005-06-04       Impact factor: 3.619

6.  Genetic variants detected among 106 lymphocyte polypeptides observed in two-dimensional gels.

Authors:  S M Hanash; L J Baier; D Welch; R Kuick; M Galteau
Journal:  Am J Hum Genet       Date:  1986-09       Impact factor: 11.025

7.  An inherited bleeding disorder linked to a defective interaction between ADP and its receptor on platelets. Its influence on glycoprotein IIb-IIIa complex function.

Authors:  P Nurden; P Savi; E Heilmann; C Bihour; J M Herbert; J P Maffrand; A Nurden
Journal:  J Clin Invest       Date:  1995-04       Impact factor: 14.808

Review 8.  Genetic dissection of platelet function in health and disease using systems biology.

Authors:  Wadie F Bahou
Journal:  Hematol Oncol Clin North Am       Date:  2013-04-09       Impact factor: 3.722

9.  Comparative proteomics in acute myeloid leukemia.

Authors:  Magdalena Luczak; Maciej Kaźmierczak; Luiza Hadschuh; Krzysztof Lewandowski; Mieczysław Komarnicki; Marek Figlerowicz
Journal:  Contemp Oncol (Pozn)       Date:  2012-05-29

10.  Esterase D and gamma 1 actin level might predict results of induction therapy in patients with acute myeloid leukemia without and with maturation.

Authors:  Maciej Kaźmierczak; Magdalena Luczak; Krzysztof Lewandowski; Luiza Handschuh; Anna Czyż; Małgorzata Jarmuż; Michał Gniot; Michał Michalak; Marek Figlerowicz; Mieczysław Komarnicki
Journal:  Med Oncol       Date:  2013-10-02       Impact factor: 3.064
  10 in total

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