Literature DB >> 3949852

Carcinogenicity of methapyrilene hydrochloride, mepyramine hydrochloride, thenyldiamine hydrochloride, and pyribenzamine hydrochloride in Sprague-Dawley rats.

M Habs, P Shubik, G Eisenbrand.   

Abstract

Four histamine antagonists, methapyrilene, thenyldiamine, mepyramine and pyribenzamine were tested for carcinogenicity in rats by continuous application in drinking water. Only methapyrilene displayed significant carcinogenic effects, inducing liver tumors in a dose-related pattern. Analogues not containing a thiophene ring (mepyramine, pyribenzamine) did not exhibit neoplastic effects under the experimental conditions.

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Year:  1986        PMID： 3949852     DOI： 10.1007/bf00402780

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  9 in total

1.  DNA damage induced by the antihistaminic drug methapyrilene hydrochloride.

Authors:  F R Althaus; S D Lawrence; G L Sattler; H C Pitot
Journal:  Mutat Res       Date:  1982-03       Impact factor: 2.433

2.  Distribution of the liver carcinogen methapyrilene in Fischer rats and its interaction with macromolecules.

Authors:  W Lijinsky; G M Muschik
Journal:  J Cancer Res Clin Oncol       Date:  1982       Impact factor: 4.553

3.  Nitrosation and mutagenicity of some amine drugs.

Authors:  A W Andrews; J A Fornwald; W Lijinsky
Journal:  Toxicol Appl Pharmacol       Date:  1980-02       Impact factor: 4.219

4.  Guidelines for simple, sensitive significance tests for carcinogenic effects in long-term animal experiments.

Authors:  R Peto; M C Pike; N E Day; R G Gray; P N Lee; S Parish; J Peto; S Richards; J Wahrendorf
Journal:  IARC Monogr Eval Carcinog Risk Chem Hum Suppl       Date:  1980

5.  The effects of methapyrilene hydrochloride on hepatocarcinogenicity and pentobarbital-induced sleeping time in rats and mice.

Authors:  L M Brennan; D A Creasia
Journal:  Toxicol Appl Pharmacol       Date:  1982-11       Impact factor: 4.219

6.  Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 rats.

Authors:  W Lijinsky
Journal:  Food Chem Toxicol       Date:  1984-01       Impact factor: 6.023

7.  Liver tumors induced in rats by oral administration of the antihistaminic methapyrilene hydrochloride.

Authors:  W Lijinsky; M D Reuber; B N Blackwell
Journal:  Science       Date:  1980-08-15       Impact factor: 47.728

8.  Early stages of chemically induced liver carcinogenesis by oral administration of the antihistaminic methapyrilene hydrochloride.

Authors:  G Fischer; M Altmannsberger; A Schauer; N Katz
Journal:  J Cancer Res Clin Oncol       Date:  1983       Impact factor: 4.553

9.  Inability of methapyrilene to induce sister chromatid exchanges in vitro and in vivo.

Authors:  P T Iype; R Ray-Chaudhuri; W Lijinsky; S P Kelley
Journal:  Cancer Res       Date:  1982-11       Impact factor: 12.701
  9 in total
  2 in total

Review 1.  Toxicogenomics in drug discovery and drug development: potential applications and future challenges.

Authors:  Tin Oo Khor; Sherif Ibrahim; Ah-Ng Tony Kong
Journal:  Pharm Res       Date:  2006-08       Impact factor: 4.200

2.  B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals.

Authors:  Alistair C Leitch; Philip M E Probert; James A Shayman; Stephanie K Meyer; George E N Kass; Matthew C Wright
Journal:  Toxicology       Date:  2017-05-26       Impact factor: 4.221
  2 in total

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