| Literature DB >> 6123945 |
F R Althaus, S D Lawrence, G L Sattler, H C Pitot.
Abstract
Treatment of primary cultures of rat hepatocytes with the antihistaminic drug, methapyrilene hydrochloride, stimulated DNA-repair synthesis up to 7-fold and caused the formation of alkaline-labile lesions in hepatocellular DNA. These data clearly demonstrate that methapyrilene hydrochloride is a DNA damaging agent. In view of a recent report and our own findings we suggest that this antihistamine has the properties of a complete carcinogen.Entities:
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Year: 1982 PMID： 6123945 DOI： 10.1016/0165-7992(82)90045-8
Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433