Literature DB >> 3920656

Isolation of morphine from toad skin.

K Oka, J D Kantrowitz, S Spector.   

Abstract

A nonpeptide opioid was found in toad skin and purified to homogeneity by using HPLC with electrochemical detection. A nonpeptide opioid also was detected in bovine brain and adrenals as well as rabbit and rat skin, by reversed-phase HPLC following Sephadex G-15 column chromatography. The material in toad skin was identical to morphine by immunological, pharmacological, and physical chemical criteria.

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Year:  1985        PMID： 3920656      PMCID： PMC397372          DOI： 10.1073/pnas.82.6.1852

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  10 in total

1.  A SENSITIVE FLUOROMETRIC ASSAY FOR MORPHINE IN PLASMA AND BRAIN.

Authors:  H KUPFERBERG; A BURKHALTER; E L WAY
Journal:  J Pharmacol Exp Ther       Date:  1964-08       Impact factor: 4.030

2.  A quantitative immunochemical measure of the primary interaction between I BSA and antibody.

Authors:  R S FARR
Journal:  J Infect Dis       Date:  1958 Nov-Dec       Impact factor: 5.226

3.  Antibodies as a means of isolating and characterizing biologically active substances: presence of a non-peptide, morphine-like compound in the central nervous system.

Authors:  A R Gintzler; A Levy; S Spector
Journal:  Proc Natl Acad Sci U S A       Date:  1976-06       Impact factor: 11.205

4.  Binding of the endogenous nonpeptide morphine-like compound to opiate receptors.

Authors:  A J Blume; J Shorr; J P Finberg; S Spector
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

5.  Opiate agonists and antagonists discriminated by receptor binding in brain.

Authors:  C B Pert; G Pasternak; S H Snyder
Journal:  Science       Date:  1973-12-28       Impact factor: 47.728

6.  Quantitative determination of morphine in serum by radioimmunoassay.

Authors:  S Spector
Journal:  J Pharmacol Exp Ther       Date:  1971-08       Impact factor: 4.030

7.  Determination of morphine and its major metabolite, morphine-3-glucuronide, in blood by high-performance liquid chromatography with electrochemical detection.

Authors:  M W White
Journal:  J Chromatogr       Date:  1979-10-19

8.  A non-peptide morphine-like compound from brain.

Authors:  A K Killian; C R Schuster; J T House; S Sholl; M Connors; B H Wainer
Journal:  Life Sci       Date:  1981-02-16       Impact factor: 5.037

9.  Presence of a non-peptide morphine-like compound in human cerebrospinal fluid.

Authors:  J Shorr; K Foley; S Spector
Journal:  Life Sci       Date:  1978-11-13       Impact factor: 5.037

10.  Morphine in cow and human milk: could dietary morphine constitute a ligand for specific morphine (mu) receptors?

Authors:  E Hazum; J J Sabatka; K J Chang; D A Brent; J W Findlay; P Cuatrecasas
Journal:  Science       Date:  1981-08-28       Impact factor: 47.728
  10 in total
  11 in total

Review 1.  Development of delta opioid peptides as nonaddicting analgesics.

Authors:  R S Rapaka; F Porreca
Journal:  Pharm Res       Date:  1991-01       Impact factor: 4.200

Review 2.  The presence of endogenous morphine signaling in animals.

Authors:  George B Stefano; Patrick Cadet; Richard M Kream; Wei Zhu
Journal:  Neurochem Res       Date:  2008-09-06       Impact factor: 3.996

3.  Urinary excretion of morphine and biosynthetic precursors in mice.

Authors:  Nadja Grobe; Marc Lamshöft; Robert G Orth; Birgit Dräger; Toni M Kutchan; Meinhart H Zenk; Michael Spiteller
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-26       Impact factor: 11.205

4.  Purification of a benzodiazepine from bovine brain and detection of benzodiazepine-like immunoreactivity in human brain.

Authors:  L Sangameswaran; H M Fales; P Friedrich; A L De Blas
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

5.  Isolation, sequence analysis, and physiological properties of enkephalins in the nervous tissue of the shore crab Carcinus maenas L.

Authors:  W Lüschen; F Buck; A Willig; P P Jaros
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-01       Impact factor: 11.205

6.  Endogenous formation of morphine in human cells.

Authors:  Chotima Poeaknapo; Jürgen Schmidt; Matthias Brandsch; Birgit Dräger; Meinhart H Zenk
Journal:  Proc Natl Acad Sci U S A       Date:  2004-09-21       Impact factor: 11.205

7.  Morphine and other opiates from beef brain and adrenal.

Authors:  A Goldstein; R W Barrett; I F James; L I Lowney; C J Weitz; L L Knipmeyer; H Rapoport
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

8.  Transformation of thebaine to oripavine, codeine, and morphine by rat liver, kidney, and brain microsomes.

Authors:  H Kodaira; S Spector
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

9.  Morphine and codeine from mammalian brain.

Authors:  C J Weitz; L I Lowney; K F Faull; G Feistner; A Goldstein
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

10.  Presence and formation of codeine and morphine in the rat.

Authors:  J Donnerer; K Oka; A Brossi; K C Rice; S Spector
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205
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