Literature DB >> 3459191

Presence and formation of codeine and morphine in the rat.

J Donnerer, K Oka, A Brossi, K C Rice, S Spector.   

Abstract

Endogenous codeine and morphine were identified in rat brain by immunological determination following HPLC. To demonstrate occurrence of a biosynthetic pathway to morphine in mammals similar to that used by the poppy plant, (+)-salutaridine, (-)-thebaine, and (-)-codeine were administered to rats intravenously. These compounds, which are intermediates in the synthesis of morphine in Papaver somniferum, caused a marked increase in the codeine and morphine levels in rat tissues. This provides evidence for a biosynthetic pathway to morphine in mammalians.

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Year:  1986        PMID： 3459191      PMCID： PMC323775          DOI： 10.1073/pnas.83.12.4566

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  10 in total

1.  INVESTIGATIONS ON THE BIOSYNTHESIS OF MORPHINE ALKALOIDS.

Authors:  D H BARTON; G W KIRBY; W STEGLICH; G M THOMAS; A R BATTERSBY; T A DOBSON; H RAMUZ
Journal:  J Chem Soc       Date:  1965-04

2.  ALKALOID BIOSYNTHESIS. 8. USE OF OPTICALLY ACTIVE PRECURSORS FOR INVESTIGATIONS ON THE BIOSYNTHESIS OF MORPHINE ALKALOIDS.

Authors:  A R BATTERSBY; D M FOULKES; R BINKS
Journal:  J Chem Soc       Date:  1965-05

3.  Antibodies as a means of isolating and characterizing biologically active substances: presence of a non-peptide, morphine-like compound in the central nervous system.

Authors:  A R Gintzler; A Levy; S Spector
Journal:  Proc Natl Acad Sci U S A       Date:  1976-06       Impact factor: 11.205

4.  Quantitative determination of morphine in serum by radioimmunoassay.

Authors:  S Spector
Journal:  J Pharmacol Exp Ther       Date:  1971-08       Impact factor: 4.030

5.  Isolation of morphine from toad skin.

Authors:  K Oka; J D Kantrowitz; S Spector
Journal:  Proc Natl Acad Sci U S A       Date:  1985-03       Impact factor: 11.205

6.  Dynorphin is a specific endogenous ligand of the kappa opioid receptor.

Authors:  C Chavkin; I F James; A Goldstein
Journal:  Science       Date:  1982-01-22       Impact factor: 47.728

7.  A non-peptide morphine-like compound from brain.

Authors:  A K Killian; C R Schuster; J T House; S Sholl; M Connors; B H Wainer
Journal:  Life Sci       Date:  1981-02-16       Impact factor: 5.037

8.  The distribution of methionine-enkephalin and leucine-enkephalin in the brain and peripheral tissues.

Authors:  J Hughes; H W Kosterlitz; T W Smith
Journal:  Br J Pharmacol       Date:  1977-12       Impact factor: 8.739

9.  Morphine and other opiates from beef brain and adrenal.

Authors:  A Goldstein; R W Barrett; I F James; L I Lowney; C J Weitz; L L Knipmeyer; H Rapoport
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

10.  Studies of the enterohepatic circulation of morphine in the rat.

Authors:  C T Walsh; R R Levine
Journal:  J Pharmacol Exp Ther       Date:  1975-11       Impact factor: 4.030
  10 in total
  18 in total

1.  An (R)-specific N-methyltransferase involved in human morphine biosynthesis.

Authors:  Nadja Grobe; Xuan Ren; Toni M Kutchan; Meinhart H Zenk
Journal:  Arch Biochem Biophys       Date:  2010-11-17       Impact factor: 4.013

Review 2.  Mu opioids and their receptors: evolution of a concept.

Authors:  Gavril W Pasternak; Ying-Xian Pan
Journal:  Pharmacol Rev       Date:  2013-09-27       Impact factor: 25.468

3.  Cytochrome P450 3A Enzymes Catalyze the O6-Demethylation of Thebaine, a Key Step in Endogenous Mammalian Morphine Biosynthesis.

Authors:  Valerie M Kramlinger; Mónica Alvarado Rojas; Tatsuyuki Kanamori; F Peter Guengerich
Journal:  J Biol Chem       Date:  2015-07-08       Impact factor: 5.157

Review 4.  The presence of endogenous morphine signaling in animals.

Authors:  George B Stefano; Patrick Cadet; Richard M Kream; Wei Zhu
Journal:  Neurochem Res       Date:  2008-09-06       Impact factor: 3.996

5.  Mammalian cytochrome P450 enzymes catalyze the phenol-coupling step in endogenous morphine biosynthesis.

Authors:  Nadja Grobe; Baichen Zhang; Ursula Fisinger; Toni M Kutchan; Meinhart H Zenk; F Peter Guengerich
Journal:  J Biol Chem       Date:  2009-06-26       Impact factor: 5.157

6.  Identification of the convulsant opiate thebaine in mammalian brain.

Authors:  H Kodaira; C A Lisek; I Jardine; A Arimura; S Spector
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205

7.  Norlaudanosoline and nicotine increase endogenous ganglionic morphine levels: nicotine addiction.

Authors:  Wei Zhu; Kirk J Mantione; Lihua Shen; Brian Lee; George B Stefano
Journal:  Cell Mol Neurobiol       Date:  2006-04-28       Impact factor: 5.046

8.  Urinary excretion of morphine and biosynthetic precursors in mice.

Authors:  Nadja Grobe; Marc Lamshöft; Robert G Orth; Birgit Dräger; Toni M Kutchan; Meinhart H Zenk; Michael Spiteller
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-26       Impact factor: 11.205

9.  Purification of a benzodiazepine from bovine brain and detection of benzodiazepine-like immunoreactivity in human brain.

Authors:  L Sangameswaran; H M Fales; P Friedrich; A L De Blas
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

Review 10.  Endogenous morphine/nitric oxide-coupled regulation of cellular physiology and gene expression: implications for cancer biology.

Authors:  George B Stefano; Richard M Kream; Kirk J Mantione; Melinda Sheehan; Patrick Cadet; Wei Zhu; Thomas V Bilfinger; Tobias Esch
Journal:  Semin Cancer Biol       Date:  2007-12-08       Impact factor: 15.707
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