Literature DB >> 3860854

Morphine and other opiates from beef brain and adrenal.

A Goldstein, R W Barrett, I F James, L I Lowney, C J Weitz, L L Knipmeyer, H Rapoport.   

Abstract

We describe nonpeptide opioids found in extracts of beef hypothalamus and adrenal, which are recognized by antisera raised against morphine. Four have been purified to homogeneity. One is morphine. The structures of the other three have not been determined yet. None of them are derived from morphine or normorphine after extraction from the tissues. It is not known whether the opiates described here are of endogenous or exogenous origin.

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Year:  1985        PMID： 3860854      PMCID： PMC390528          DOI： 10.1073/pnas.82.15.5203

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  15 in total

1.  Preparation of iodine-131 labelled human growth hormone of high specific activity.

Authors:  W M HUNTER; F C GREENWOOD
Journal:  Nature       Date:  1962-05-05       Impact factor: 49.962

2.  Binding of the endogenous nonpeptide morphine-like compound to opiate receptors.

Authors:  A J Blume; J Shorr; J P Finberg; S Spector
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

3.  A nonpeptide morphine-like compound: immunocytochemical localization in the mouse brain.

Authors:  A R Gintzler; M D Gershon; S Spector
Journal:  Science       Date:  1978-01-27       Impact factor: 47.728

4.  Isolation of morphine from toad skin.

Authors:  K Oka; J D Kantrowitz; S Spector
Journal:  Proc Natl Acad Sci U S A       Date:  1985-03       Impact factor: 11.205

5.  Site-directed alkylation of multiple opioid receptors. II. Pharmacological selectivity.

Authors:  A Goldstein; I F James
Journal:  Mol Pharmacol       Date:  1984-05       Impact factor: 4.436

6.  A non-peptide morphine-like compound from brain.

Authors:  A K Killian; C R Schuster; J T House; S Sholl; M Connors; B H Wainer
Journal:  Life Sci       Date:  1981-02-16       Impact factor: 5.037

7.  Presence of a non-peptide morphine-like compound in human cerebrospinal fluid.

Authors:  J Shorr; K Foley; S Spector
Journal:  Life Sci       Date:  1978-11-13       Impact factor: 5.037

8.  Opioid receptor selectivity of dynorphin gene products.

Authors:  I F James; W Fischli; A Goldstein
Journal:  J Pharmacol Exp Ther       Date:  1984-01       Impact factor: 4.030

Review 9.  Biosynthesis of the morphine alkaloids.

Authors:  G W Kirby
Journal:  Science       Date:  1967-01-13       Impact factor: 47.728

10.  Analogues of beta-LPH61-64 possessing selective agonist activity at mu-opiate receptors.

Authors:  B K Handa; A C Land; J A Lord; B A Morgan; M J Rance; C F Smith
Journal:  Eur J Pharmacol       Date:  1981-04-09       Impact factor: 4.432
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  19 in total

1.  An (R)-specific N-methyltransferase involved in human morphine biosynthesis.

Authors:  Nadja Grobe; Xuan Ren; Toni M Kutchan; Meinhart H Zenk
Journal:  Arch Biochem Biophys       Date:  2010-11-17       Impact factor: 4.013

Review 2.  Mu opioids and their receptors: evolution of a concept.

Authors:  Gavril W Pasternak; Ying-Xian Pan
Journal:  Pharmacol Rev       Date:  2013-09-27       Impact factor: 25.468

3.  Cytochrome P450 3A Enzymes Catalyze the O6-Demethylation of Thebaine, a Key Step in Endogenous Mammalian Morphine Biosynthesis.

Authors:  Valerie M Kramlinger; Mónica Alvarado Rojas; Tatsuyuki Kanamori; F Peter Guengerich
Journal:  J Biol Chem       Date:  2015-07-08       Impact factor: 5.157

Review 4.  The presence of endogenous morphine signaling in animals.

Authors:  George B Stefano; Patrick Cadet; Richard M Kream; Wei Zhu
Journal:  Neurochem Res       Date:  2008-09-06       Impact factor: 3.996

Review 5.  The molecular structure of opiate receptors.

Authors:  M Wollemann
Journal:  Neurochem Res       Date:  1987-02       Impact factor: 3.996

6.  Norlaudanosoline and nicotine increase endogenous ganglionic morphine levels: nicotine addiction.

Authors:  Wei Zhu; Kirk J Mantione; Lihua Shen; Brian Lee; George B Stefano
Journal:  Cell Mol Neurobiol       Date:  2006-04-28       Impact factor: 5.046

7.  Urinary excretion of morphine and biosynthetic precursors in mice.

Authors:  Nadja Grobe; Marc Lamshöft; Robert G Orth; Birgit Dräger; Toni M Kutchan; Meinhart H Zenk; Michael Spiteller
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-26       Impact factor: 11.205

8.  Purification of a benzodiazepine from bovine brain and detection of benzodiazepine-like immunoreactivity in human brain.

Authors:  L Sangameswaran; H M Fales; P Friedrich; A L De Blas
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

9.  Endogenous formation of morphine in human cells.

Authors:  Chotima Poeaknapo; Jürgen Schmidt; Matthias Brandsch; Birgit Dräger; Meinhart H Zenk
Journal:  Proc Natl Acad Sci U S A       Date:  2004-09-21       Impact factor: 11.205

10.  Endogenous morphine levels are increased in sepsis: a partial implication of neutrophils.

Authors:  Elise Glattard; Ingeborg D Welters; Thomas Lavaux; Arnaud H Muller; Alexis Laux; Dan Zhang; Alexander R Schmidt; François Delalande; Benoît-Joseph Laventie; Sylvie Dirrig-Grosch; Didier A Colin; Alain Van Dorsselaer; Dominique Aunis; Marie-Hélène Metz-Boutigue; Francis Schneider; Yannick Goumon
Journal:  PLoS One       Date:  2010-01-20       Impact factor: 3.240
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