Literature DB >> 3919139

Characterization of an epibody. An antiidiotype that reacts with both the idiotype of rheumatoid factors (RF) and the antigen recognized by RF.

P P Chen, S Fong, R A Houghten, D A Carson.   

Abstract

Recently, an antiidiotype to human monoclonal IgM anti-IgG autoantibodies (rheumatoid factors) was found to react also with human IgG. This peculiar antiidiotype was called an 'epibody'. We describe the induction of a similar epibody by immunization with a synthetic peptide (corresponding to one hypervariable region of the IgM-RF Glo). The results confirm the existence of epibodies, and provide the possible molecular basis of the epibody phenomenon.

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Year:  1985        PMID： 3919139      PMCID： PMC2187561          DOI： 10.1084/jem.161.2.323

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  19 in total

1.  Individual Antigenic Specificity of Isolated Antibodies.

Authors:  H G Kunkel; M Mannik; R C Williams
Journal:  Science       Date:  1963-06-14       Impact factor: 47.728

2.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors:  H Towbin; T Staehelin; J Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

3.  Immunochemical studies on the tobacco mosaic virus protein. VII. The binding of octanoylated peptides of the tobacco mosaic virus protein with antibodies to the whole protein.

Authors:  E Benjamini; M Shimizu; J D Young; C Y Leung
Journal:  Biochemistry       Date:  1968-04       Impact factor: 3.162

4.  Anti-hypervariable region antibody induced by a defined peptide: an approach for studying the structural correlates of idiotypes.

Authors:  P P Chen; R A Houghten; S Fong; G H Rhodes; T A Gilbertson; J H Vaughan; R A Lerner; D A Carson
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205

5.  Anti-RNP monoclonal antibodies derived from a mouse strain with lupus-like autoimmunity.

Authors:  P B Billings; R W Allen; F C Jensen; S O Hoch
Journal:  J Immunol       Date:  1982-03       Impact factor: 5.422

6.  Hypervariable regions, idiotypy, and the antibody-combining site.

Authors:  J D Capra; J M Kehoe
Journal:  Adv Immunol       Date:  1975       Impact factor: 3.543

7.  Rheumatoid factors and secondary immune responses in the mouse. I. Frequent occurrence of hybridomas secreting IgM anti-IgG1 autoantibodies after immunization with protein antigens.

Authors:  J Van Snick; P Coulie
Journal:  Eur J Immunol       Date:  1983-11       Impact factor: 5.532

8.  The internal image of IgG in cross-reactive anti-idiotypic antibodies against human rheumatoid factors.

Authors:  S Fong; T A Gilbertson; D A Carson
Journal:  J Immunol       Date:  1983-08       Impact factor: 5.422

9.  A common idiotope on human rheumatoid factors identified by a hybridoma antibody.

Authors:  D A Carson; S Fong
Journal:  Mol Immunol       Date:  1983-10       Impact factor: 4.407

10.  Induction of rheumatoid antibodies in the mouse. Regulated production of autoantibody in the secondary humoral response.

Authors:  D A Nemazee; V L Sato
Journal:  J Exp Med       Date:  1983-08-01       Impact factor: 14.307
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  12 in total

1.  General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

Authors:  R A Houghten
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

2.  Evolutionary origin of autoreactive determinants (autogens).

Authors:  T Kieber-Emmons; H Kohler
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

3.  Fine specificity, idiotypy, and nature of cloned heavy-chain variable region genes of murine monoclonal rheumatoid factor antibodies.

Authors:  A J Manheimer-Lory; M Monestier; B Bellon; F W Alt; C A Bona
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

4.  Monoclonal antibodies defining a minor and a private idiotope on human rheumatoid factors.

Authors:  J L Pasquali; D Storck
Journal:  J Clin Immunol       Date:  1986-09       Impact factor: 8.317

Review 5.  Cross-reacting idiotypes on cryoprecipitating rheumatoid factor.

Authors:  P P Chen; S Fong; F Goni; G J Silverman; R I Fox; M F Liu; B Frangione; D A Carson
Journal:  Springer Semin Immunopathol       Date:  1988

6.  Molecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseases.

Authors:  T Olee; P M Yang; K A Siminovitch; N J Olsen; J Hillson; J Wu; F Kozin; D A Carson; P P Chen
Journal:  J Clin Invest       Date:  1991-07       Impact factor: 14.808

7.  Human IgG anti-F(ab')2 antibodies possess rheumatoid factor activity.

Authors:  S Hunt Gerardo; J E Persselin; R H Stevens
Journal:  Clin Exp Immunol       Date:  1990-08       Impact factor: 4.330

8.  Antibodies with idiotypic and anti-idiotypic reactivity (epibodies) in conventional immune responses to dinitrophenylated carriers.

Authors:  L Muhumuza; D Segre; M Segre
Journal:  Immunology       Date:  1998-04       Impact factor: 7.397

9.  An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice.

Authors:  A Puccetti; T Koizumi; P Migliorini; J André-Schwartz; K J Barrett; R S Schwartz
Journal:  J Exp Med       Date:  1990-06-01       Impact factor: 14.307

10.  Characterization of human rheumatoid factors with seven antiidiotypes induced by synthetic hypervariable region peptides.

Authors:  P P Chen; F Gõni; R A Houghten; S Fong; R Goldfien; J H Vaughan; B Frangione; D A Carson
Journal:  J Exp Med       Date:  1985-08-01       Impact factor: 14.307
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