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Literature DB >> 1693654

An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice.

A Puccetti¹, T Koizumi, P Migliorini, J André-Schwartz, K J Barrett, R S Schwartz.

Abstract

Autoantibodies against the 70-kD U1 RNP nucleoprotein autoantigen and DNA were elicited in normal BALB/c mice with a purified Ig light chain. This light chain, derived from a lupus-prone MRL-lpr/lpr mouse, has two distinctive properties: it contains an idiotypic marker recognized by a monoclonal MRL-lpr/lpr anti-snRNP autoantibody, and the amino acid sequence of its third hypervariable region (CDR3) is homologous to a sequence in an antigenic region of the 70-kD U1 RNP polypeptide. The results demonstrate that an Ig idiotype that mimics an autoantigen can induce autoimmunization.

Entities: Gene Species

Mesh：

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Year: 1990 PMID： 1693654 PMCID： PMC2187956 DOI： 10.1084/jem.171.6.1919

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

32 in total

1. Nucleic acid sequence of an internal image-bearing monoclonal anti-idiotype and its comparison to the sequence of the external antigen.

Authors: C Bruck; M S Co; M Slaoui; G N Gaulton; T Smith; B N Fields; J I Mullins; M I Greene
Journal: Proc Natl Acad Sci U S A Date: 1986-09 Impact factor: 11.205

2. Autoantibodies to the Sm antigen: immunological approach to clinical aspects of systemic lupus erythematosus.

Authors: M Homma; T Mimori; Y Takeda; H Akama; T Yoshida; T Ogasawara; M Akizuki
Journal: J Rheumatol Suppl Date: 1987-06

3. Epitope mapping with a recombinant human 68-kDa (U1) ribonucleoprotein antigen reveals heterogeneous autoantibody profiles in human autoimmune sera.

Authors: H H Guldner; H J Netter; C Szostecki; H J Lakomek; H Will
Journal: J Immunol Date: 1988-07-15 Impact factor: 5.422

Review 4. Antinuclear antibodies (ANAs): diagnostically specific immune markers and clues toward the understanding of systemic autoimmunity.

Authors: E M Tan; E K Chan; K F Sullivan; R L Rubin
Journal: Clin Immunol Immunopathol Date: 1988-05

5. Induction of a systemic lupus erythematosus-like disease in mice by a common human anti-DNA idiotype.

Authors: S Mendlovic; S Brocke; Y Shoenfeld; M Ben-Bassat; A Meshorer; R Bakimer; E Mozes
Journal: Proc Natl Acad Sci U S A Date: 1988-04 Impact factor: 11.205

6. Induction of anti-double stranded DNA antibodies in normal mice by immunization with bacterial DNA.

Authors: G S Gilkeson; J P Grudier; D G Karounos; D S Pisetsky
Journal: J Immunol Date: 1989-03-01 Impact factor: 5.422

7. Immunization of mice with purified U1 small nuclear ribonucleoprotein (RNP) induces a pattern of antibody specificities characteristic of the anti-Sm and anti-RNP autoimmune response of patients with lupus erythematosus, as measured by monoclonal antibodies.

Authors: R Reuter; R Lührmann
Journal: Proc Natl Acad Sci U S A Date: 1986-11 Impact factor: 11.205

8. Do antibodies recognize amino acid side chains of protein antigens independently of the carbon backbone?

Authors: V H Van Cleave; C W Naeve; D W Metzger
Journal: J Exp Med Date: 1988-06-01 Impact factor: 14.307

9. Parallel sets of autoantibodies in MRL-lpr/lpr mice. An anti-DNA, anti-SmRNP, anti-gp70 network.

Authors: P Migliorini; B Ardman; J Kaburaki; R S Schwartz
Journal: J Exp Med Date: 1987-02-01 Impact factor: 14.307

10. Cross-reactivity between C-reactive protein and idiotypic determinants on A phosphocholine-binding murine myeloma protein.

Authors: J E Volanakis; J F Kearney
Journal: J Exp Med Date: 1981-06-01 Impact factor: 14.307

11 in total

1. Amphipathic variable region heavy chain peptides derived from monoclonal human Wegener's anti-PR3 antibodies stimulate lymphocytes from patients with Wegener's granulomatosis and microscopic polyangiitis.

Authors: E Peen; C Malone; C Myers; R C Williams; A B Peck; E Csernok; W L Gross; R Staud
Journal: Clin Exp Immunol Date: 2001-08 Impact factor: 4.330

2. A peptide derived from a polyreactive monoclonal anti-DNA natural antibody can modulate lupus development in (NZBxNZW)F1 mice.

Authors: C Jouanne; S Avrameas; B Payelle-Brogard
Journal: Immunology Date: 1999-03 Impact factor: 7.397

3. Immune tolerance to autoantibody-derived peptides delays development of autoimmunity in murine lupus.

Authors: R R Singh; F M Ebling; E E Sercarz; B H Hahn
Journal: J Clin Invest Date: 1995-12 Impact factor: 14.808

4. Primary sequence and location of the idiotopes of V-88, a DNA-binding monoclonal autoantibody, determined by idiotope scanning with synthetic peptides on pins.

Authors: N A Staines; F J Ward; A N Denbury; J Mitchiner; O Hartley; D Eilat; D A Isenberg; S Bansal
Journal: Immunology Date: 1993-03 Impact factor: 7.397

5. Expression of public idiotypes in patients with Lyme arthritis.

Authors: J S Axford; R A Watts; A A Long; D A Isenberg; A C Steere
Journal: Ann Rheum Dis Date: 1993-03 Impact factor: 19.103

Review 6. Abnormalities in the regulation of variable region genes that encode for antibodies to DNA may be a central factor in the pathogenesis of systemic lupus erythematosus.

Authors: A K Singh
Journal: Ann Rheum Dis Date: 1993-05 Impact factor: 19.103