Literature DB >> 3095832

Fine specificity, idiotypy, and nature of cloned heavy-chain variable region genes of murine monoclonal rheumatoid factor antibodies.

A J Manheimer-Lory, M Monestier, B Bellon, F W Alt, C A Bona.   

Abstract

We investigated the immunochemical and molecular characteristics of murine monoclonal rheumatoid factors. Study of the fine specificity of 20 monoclonal rheumatoid factor antibodies shows a wide degree of heterogeneity. However, many express an interstrain cross-reactive idiotype. We show that our rheumatoid factors utilize a restricted set of the heavy-chain variable region (VH) repertoire representing the more 3' VH families. Preferential expression of 3' VH families is known to occur early in development. We report the nucleotide sequence of two cloned rheumatoid factor VH genes, Y19-10 (VH J558) and 129-48 (VH 7183) in which no major differences are observed between VH genes encoding the heavy chain of autoantibodies and antibodies against foreign antigens.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3095832      PMCID： PMC386914          DOI： 10.1073/pnas.83.21.8293

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

1.  Continuous cultures of fused cells secreting antibody of predefined specificity.

Authors:  G Köhler; C Milstein
Journal:  Nature       Date:  1975-08-07       Impact factor: 49.962

2.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

3.  Charon phages: safer derivatives of bacteriophage lambda for DNA cloning.

Authors:  F R Blattner; B G Williams; A E Blechl; K Denniston-Thompson; H E Faber; L Furlong; D J Grunwald; D O Kiefer; D D Moore; J W Schumm; E L Sheldon; O Smithies
Journal:  Science       Date:  1977-04-08       Impact factor: 47.728

4.  Cytoplasmic dot hybridization. Simple analysis of relative mRNA levels in multiple small cell or tissue samples.

Authors:  B A White; F C Bancroft
Journal:  J Biol Chem       Date:  1982-08-10       Impact factor: 5.157

5.  Sequencing end-labeled DNA with base-specific chemical cleavages.

Authors:  A M Maxam; W Gilbert
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

Review 6.  Structural correlates of idiotypy in the arsonate system.

Authors:  M N Margolies; E C Juszczak; R Near; A Marshak-Rothstein; T L Rothstein; V L Sato; M Siekevitz; J A Smith; L J Wysocki; M L Gefter
Journal:  Ann N Y Acad Sci       Date:  1983       Impact factor: 5.691

7.  Identification of DNA fragments carrying ecotropic proviruses of AKR mice.

Authors:  D Steffen; S Bird; W P Rowe; R A Weinberg
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

8.  Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines.

Authors:  F W Alt; N Rosenberg; V Enea; E Siden; D Baltimore
Journal:  Mol Cell Biol       Date:  1982-04       Impact factor: 4.272

9.  Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain.

Authors:  F W Alt; V Enea; A L Bothwell; D Baltimore
Journal:  Cell       Date:  1980-08       Impact factor: 41.582

10.  Delineation of a cross-reactive idiotype on human autoantibodies with antibody against a synthetic peptide.

Authors:  P P Chen; S Fong; D Normansell; R A Houghten; J G Karras; J H Vaughan; D A Carson
Journal:  J Exp Med       Date:  1984-05-01       Impact factor: 14.307
View more
  15 in total

Review 1.  Pairing of VK and VK gene families in self-reactive antibodies.

Authors:  C A Bona; Y Saitoh; G Kelsoe
Journal:  J Clin Immunol       Date:  1990-09       Impact factor: 8.317

2.  Molecular basis for expression of the A48 regulatory idiotope on antibodies encoded by immunoglobulin variable-region genes from various families.

Authors:  H Zaghouani; F A Bonilla; K Meek; C Bona
Journal:  Proc Natl Acad Sci U S A       Date:  1989-04       Impact factor: 11.205

3.  Nucleotide changes in sequential variants of influenza virus hemagglutinin genes and molecular structures of corresponding monoclonal antibodies specific for each variant.

Authors:  K Meek; B Johansson; J Schulman; C Bona; J D Capra
Journal:  Proc Natl Acad Sci U S A       Date:  1989-06       Impact factor: 11.205

4.  Molecular characterization of the variable regions of a mouse polyreactive IgG2b antibody with rheumatoid factor activity.

Authors:  A Sequeira; S Avrameas; E Jouvin-Marche
Journal:  Immunogenetics       Date:  1992       Impact factor: 2.846

Review 5.  Genes regulating rheumatoid factors.

Authors:  C A Bona
Journal:  Springer Semin Immunopathol       Date:  1988

6.  Kappa/lambda immunoglobulin distribution in Graves' thyroid-stimulating antibodies. Simultaneous analysis of C lambda gene polymorphisms.

Authors:  R C Williams; N J Marshall; K Kilpatrick; J Montano; P M Brickell; M Goodall; P A Ealey; B Shine; A P Weetman; R K Craig
Journal:  J Clin Invest       Date:  1988-10       Impact factor: 14.808

7.  Molecular heterogeneity of antigen- or idiotype-induced anti-thyroglobulin monoclonal autoantibodies.

Authors:  C Bedin; A Ropars; K Mignon-Godefroy; J Charreire
Journal:  Clin Exp Immunol       Date:  1995-06       Impact factor: 4.330

8.  Molecular mechanisms resulting in pathogenic anti-mouse erythrocyte antibodies in New Zealand black mice.

Authors:  B B Scott; S Sadigh; M Stow; R A Mageed; E M Andrew; R N Maini
Journal:  Clin Exp Immunol       Date:  1993-07       Impact factor: 4.330

9.  High frequency of autoantibodies bearing cross-reactive idiotopes among hybridomas using VH7183 genes prepared from normal and autoimmune murine strains.

Authors:  B Bellon; A Manheimer-Lory; M Monestier; T Moran; A Dimitriu-Bona; F Alt; C Bona
Journal:  J Clin Invest       Date:  1987-04       Impact factor: 14.808

10.  Isoelectric focusing characterization of IgM-VKiiib immunoglobulin light chains and their association with anti-IgG autoantibodies in essential mixed cryoglobulinaemia, Sjögren's syndrome and rheumatoid arthritis.

Authors:  J M Williams; P D Gorevic; R J Looney; G N Abraham
Journal:  Immunology       Date:  1987-12       Impact factor: 7.397
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.