Literature DB >> 3898419

Purified flagella from Treponema phagedenis biotype Reiter does not induce protective immunity against experimental syphilis in rabbits.

P Hindersson, C S Petersen, N H Axelsen.   

Abstract

Thirteen rabbits were immunized three times at weekly intervals with 50 micrograms of flagella purified from Treponema phagedenis biotype Reiter. Fourteen rabbits were inoculated in the same way with a placebo preparation. Rabbits immunized with the flagella developed an immune response to the flagella but showed no statistically significant prolongation of incubation time or diminution of lesion severity when challenged intradermally with 4 X 10(3) Treponema pallidum organisms.

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Year:  1985        PMID： 3898419     DOI： 10.1097/00007435-198507000-00006

Source DB:  PubMed          Journal:  Sex Transm Dis        ISSN： 0148-5717            Impact factor:   2.830


  6 in total

Review 1.  Biological basis for syphilis.

Authors:  Rebecca E Lafond; Sheila A Lukehart
Journal:  Clin Microbiol Rev       Date:  2006-01       Impact factor: 26.132

2.  Opsonization of Treponema pallidum is mediated by immunoglobulin G antibodies induced only by pathogenic treponemes.

Authors:  J M Shaffer; S A Baker-Zander; S A Lukehart
Journal:  Infect Immun       Date:  1993-02       Impact factor: 3.441

3.  Immunization with Treponema pallidum endoflagella alters the course of experimental rabbit syphilis.

Authors:  C I Champion; J N Miller; L A Borenstein; M A Lovett; D R Blanco
Journal:  Infect Immun       Date:  1990-09       Impact factor: 3.441

4.  Cloning and characterization of Treponema hyodysenteriae antigens and protection in a CF-1 mouse model by immunization with a cloned endoflagellar antigen.

Authors:  D A Boyden; F G Albert; C S Robinson
Journal:  Infect Immun       Date:  1989-12       Impact factor: 3.441

5.  Monoclonal antibody selection and analysis of a recombinant DNA-derived surface immunogen of Treponema pallidum expressed in Escherichia coli.

Authors:  M A Swancutt; D A Twehous; M V Norgard
Journal:  Infect Immun       Date:  1986-04       Impact factor: 3.441

Review 6.  Polypeptides of Treponema pallidum: progress toward understanding their structural, functional, and immunologic roles. Treponema Pallidum Polypeptide Research Group.

Authors:  S J Norris
Journal:  Microbiol Rev       Date:  1993-09
  6 in total

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