Literature DB >> 8423106

Opsonization of Treponema pallidum is mediated by immunoglobulin G antibodies induced only by pathogenic treponemes.

J M Shaffer1, S A Baker-Zander, S A Lukehart.   

Abstract

Rabbit antisera to Leptospira interrogans, Borrelia hermsii, and Treponema phagedenis biotype Reiter, reactive to shared spirochetal antigens, failed to enhance phagocytosis of Treponema pallidum by macrophages, while immunoglobulin G to Treponema pallidum subsp. pertenue and Treponema paraluiscuniculi promoted phagocytosis. Opsonic antibodies are directed to pathogen-restricted, not shared spirochetal, antigens.

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Year:  1993        PMID： 8423106      PMCID： PMC302795          DOI： 10.1128/iai.61.2.781-784.1993

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  42 in total

1.  Protective layer covering pathogenic treponemata.

Authors:  S CHRISTIANSEN
Journal:  Lancet       Date:  1963-02-23       Impact factor: 79.321

2.  Electron microscopy of treponemes subjected to the Treponema pallidum immobilization (TPI) test. I. Comparison of immunoimmobilized cells and control cells.

Authors:  K Hovind-Hougen; H A Nielsen; A Birch-Andersen
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Authors:  J N Miller
Journal:  J Immunol       Date:  1973-05       Impact factor: 5.422

4.  Attempts at immunization against syphilis with avirulent Treponemma pallidum.

Authors:  N N Izzat; W G Dacres; J M Knox; R Wende
Journal:  Br J Vener Dis       Date:  1970-12

5.  The immunoprotective niche--a new pathogenic mechanism for syphilis, the systemic mycoses and other infectious diseases.

Authors:  M A Medici
Journal:  J Theor Biol       Date:  1972-09       Impact factor: 2.691

6.  Rapid in vitro immobilisation of purified Treponema pallidum (Nichols strain), and protection by extraction fluids from rabbit testes.

Authors:  H J Engelkens; M Kant; P C Onvlee; E Stolz; J J van der Sluis
Journal:  Genitourin Med       Date:  1990-10

7.  The outer membrane, not a coat of host proteins, limits antigenicity of virulent Treponema pallidum.

Authors:  D L Cox; P Chang; A W McDowall; J D Radolf
Journal:  Infect Immun       Date:  1992-03       Impact factor: 3.441

8.  Immunity in syphilis. Studies in active immunity.

Authors:  H T Al-Samarrai; W G Henderson
Journal:  Br J Vener Dis       Date:  1976-10

9.  Analysis of outer membrane ultrastructure of pathogenic Treponema and Borrelia species by freeze-fracture electron microscopy.

Authors:  E M Walker; L A Borenstein; D R Blanco; J N Miller; M A Lovett
Journal:  J Bacteriol       Date:  1991-09       Impact factor: 3.490

10.  Demonstration of the in vitro phagocytosis of Treponema pallidum by rabbit peritoneal macrophages.

Authors:  S A Lukehart; J N Miller
Journal:  J Immunol       Date:  1978-11       Impact factor: 5.422
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  13 in total

Review 1.  Syphilis: using modern approaches to understand an old disease.

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Authors:  Rebecca E Lafond; Sheila A Lukehart
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3.  Reduced Treponema pallidum-Specific Opsonic Antibody Activity in HIV-Infected Patients With Syphilis.

Authors:  Christina M Marra; Lauren C Tantalo; Sharon K Sahi; Shelia B Dunaway; Sheila A Lukehart
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Review 4.  Vaccine development for syphilis.

Authors:  Karen V Lithgow; Caroline E Cameron
Journal:  Expert Rev Vaccines       Date:  2016-07-18       Impact factor: 5.217

5.  Evaluation of the Protective Ability of the Treponema pallidum subsp. pallidum Tp0126 OmpW Homolog in the Rabbit Model of Syphilis.

Authors:  Austin M Haynes; Charmie Godornes; Wujian Ke; Lorenzo Giacani
Journal:  Infect Immun       Date:  2019-07-23       Impact factor: 3.441

6.  Genetic and transcriptional analysis of flgB flagellar operon constituents in the oral spirochete Treponema denticola and their heterologous expression in enteric bacteria.

Authors:  H F Heinzerling; M Olivares; R A Burne
Journal:  Infect Immun       Date:  1997-06       Impact factor: 3.441

7.  Antigenic variation in Treponema pallidum: TprK sequence diversity accumulates in response to immune pressure during experimental syphilis.

Authors:  Lorenzo Giacani; Barbara J Molini; Eric Y Kim; B Charmie Godornes; B Troy Leader; Lauren C Tantalo; Arturo Centurion-Lara; Sheila A Lukehart
Journal:  J Immunol       Date:  2010-02-26       Impact factor: 5.422

8.  Tromp1, a putative rare outer membrane protein, is anchored by an uncleaved signal sequence to the Treponema pallidum cytoplasmic membrane.

Authors:  D R Akins; E Robinson; D Shevchenko; C Elkins; D L Cox; J D Radolf
Journal:  J Bacteriol       Date:  1997-08       Impact factor: 3.490

9.  Function and protective capacity of Treponema pallidum subsp. pallidum glycerophosphodiester phosphodiesterase.

Authors:  C E Cameron; C Castro; S A Lukehart; W C Van Voorhis
Journal:  Infect Immun       Date:  1998-12       Impact factor: 3.441

10.  Activation and proteolytic activity of the Treponema pallidum metalloprotease, pallilysin.

Authors:  Simon Houston; Rebecca Hof; Lisa Honeyman; Julia Hassler; Caroline E Cameron
Journal:  PLoS Pathog       Date:  2012-07-26       Impact factor: 6.823
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