Literature DB >> 2201648

Immunization with Treponema pallidum endoflagella alters the course of experimental rabbit syphilis.

C I Champion1, J N Miller, L A Borenstein, M A Lovett, D R Blanco.   

Abstract

Rabbits were immunized over a 32-week period with a total of 450 micrograms of purified Treponema pallidum endoflagella. As measured by enzyme-linked immunosorbent assay, sera from immunized rabbits had antiendoflagellar antibody titers that were fivefold greater than titers of sera from infected immune rabbits and patients with secondary disease. Sera from all immunized animals possessed complement-dependent treponemicidal activity as measured by in vitro immobilization. Immunized animals challenged with virulent T. pallidum were not protected from symptomatic infection but showed an altered course of lesion development.

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Year:  1990        PMID： 2201648      PMCID： PMC313628          DOI： 10.1128/iai.58.9.3158-3161.1990

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  16 in total

1.  STUDIES ON IMMUNITY IN EXPERIMENTAL SYPHILIS. I. IMMUNOLOGIC RESPONSE OF RABBITS IMMUNIZED WITH REITER PROTEIN ANTIGEN AND CHALLENGED WITH VIRULENT TREPONEMA PALLIDUM.

Authors:  J N MILLER; S J WHANG; F P FAZZAN
Journal:  Br J Vener Dis       Date:  1963-09

2.  Antigenic and structural characterization of Treponema pallidum (Nichols strain) endoflagella.

Authors:  D R Blanco; C I Champion; J N Miller; M A Lovett
Journal:  Infect Immun       Date:  1988-01       Impact factor: 3.441

3.  Development of cellular immunity to individual soluble antigens of Treponema pallidum during experimental syphilis.

Authors:  S A Baker-Zander; M J Fohn; S A Lukehart
Journal:  J Immunol       Date:  1988-12-15       Impact factor: 5.422

4.  Immunogenic properties of the protein component of Treponema pallidum.

Authors:  M Metzger; E Michalska; J Podwińska; W Smogór
Journal:  Br J Vener Dis       Date:  1969-12

5.  Correlation of treponemicidal activity in normal human serum with the presence of IgG antibody directed against polypeptides of Treponema phagedenis biotype Reiter and Treponema pallidum, Nichols strain.

Authors:  D R Blanco; J D Radolf; M A Lovett; J N Miller
Journal:  J Immunol       Date:  1986-09-15       Impact factor: 5.422

6.  Analysis of sheath and core structures of the axial filament of Treponema pallidum.

Authors:  A Cockayne; M J Bailey; C W Penn
Journal:  J Gen Microbiol       Date:  1987-06

7.  Purified flagella from Treponema phagedenis biotype Reiter does not induce protective immunity against experimental syphilis in rabbits.

Authors:  P Hindersson; C S Petersen; N H Axelsen
Journal:  Sex Transm Dis       Date:  1985 Jul-Sep       Impact factor: 2.830

8.  The antigenic interrelationship between the endoflagella of Treponema phagedenis biotype Reiter and Treponema pallidum Nichols strain. I. Treponemicidal activity of cross-reactive endoflagellar antibodies against T. pallidum.

Authors:  D R Blanco; J D Radolf; M A Lovett; J N Miller
Journal:  J Immunol       Date:  1986-11-01       Impact factor: 5.422

9.  Immunization of rabbits with recombinant Treponema pallidum surface antigen 4D alters the course of experimental syphilis.

Authors:  L A Borenstein; J D Radolf; T E Fehniger; D R Blanco; J N Miller; M A Lovett
Journal:  J Immunol       Date:  1988-04-01       Impact factor: 5.422

10.  Isolation and characterization of recombinant Escherichia coli clones secreting a 24-kilodalton antigen of Treponema pallidum.

Authors:  P L Hsu; M Qin; S J Norris; S Sell
Journal:  Infect Immun       Date:  1988-05       Impact factor: 3.441
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  21 in total

Review 1.  Spirochaetal lipoproteins and pathogenesis.

Authors:  D A Haake
Journal:  Microbiology       Date:  2000-07       Impact factor: 2.777

2.  Membrane topology and cellular location of the Treponema pallidum glycerophosphodiester phosphodiesterase (GlpQ) ortholog.

Authors:  D V Shevchenko; T J Sellati; D L Cox; O V Shevchenko; E J Robinson; J D Radolf
Journal:  Infect Immun       Date:  1999-05       Impact factor: 3.441

3.  Epitope mapping of B-cell determinants on the 15-kilodalton lipoprotein of Treponema pallidum (Tpp15) with synthetic peptides.

Authors:  R E Baughn; M Demecs; L H Taber; D M Musher
Journal:  Infect Immun       Date:  1996-07       Impact factor: 3.441

4.  Quantitative assessment of protection in experimental syphilis.

Authors:  Cheryl I Champion; David R Blanco; Michael A Lovett
Journal:  Infect Immun       Date:  2005-09       Impact factor: 3.441

Review 5.  Biological basis for syphilis.

Authors:  Rebecca E Lafond; Sheila A Lukehart
Journal:  Clin Microbiol Rev       Date:  2006-01       Impact factor: 26.132

Review 6.  Vaccine development for syphilis.

Authors:  Karen V Lithgow; Caroline E Cameron
Journal:  Expert Rev Vaccines       Date:  2016-07-18       Impact factor: 5.217

7.  Motility and chemotaxis in tissue penetration of oral epithelial cell layers by Treponema denticola.

Authors:  R Lux; J N Miller; N H Park; W Shi
Journal:  Infect Immun       Date:  2001-10       Impact factor: 3.441

8.  Function and protective capacity of Treponema pallidum subsp. pallidum glycerophosphodiester phosphodiesterase.

Authors:  C E Cameron; C Castro; S A Lukehart; W C Van Voorhis
Journal:  Infect Immun       Date:  1998-12       Impact factor: 3.441

Review 9.  Outer membrane proteins of pathogenic spirochetes.

Authors:  Paul A Cullen; David A Haake; Ben Adler
Journal:  FEMS Microbiol Rev       Date:  2004-06       Impact factor: 16.408

10.  Immunization of guinea pigs with recombinant TmpB antigen induces protection against challenge infection with Treponema pallidum Nichols.

Authors:  K Wicher; L M Schouls; V Wicher; J D Van Embden; S S Nakeeb
Journal:  Infect Immun       Date:  1991-12       Impact factor: 3.441
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