Literature DB >> 3891595

Comparison of the pharmacological profiles of cyclosporine, (Nva2)-cyclosporine and (Val2)dihydro-cyclosporine.

P C Hiestand, H C Gunn, J M Gale, B Ryffel, J F Borel.   

Abstract

The pharmacological profiles of two new derivatives of the immunosuppressive drug, cyclosporine, is presented here. (Nva2)-CS has very similar properties to CS, but lacks the nephrotoxic side-effects. This derivative appears to be a potential successor to cyclosporine. (Val2)DH-CS seems to have a different spectrum of activities. It does not suppress humoral immunity and allograft rejection, but suppresses some types of cell-mediated immune responses. This derivative may prove useful in autoimmune situations where T cells are involved in the disease process.

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Year:  1985        PMID： 3891595      PMCID： PMC1453611     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  6 in total

1.  Biological effects of cyclosporin A: a new antilymphocytic agent.

Authors:  J F Borel; C Feurer; H U Gubler; H Stähelin
Journal:  Agents Actions       Date:  1976-07

2.  Crystal and molecular structure of an iodo-derivative of the cyclic undecapeptide cyclosporin A.

Authors:  T J Petcher; H Weber; A Rüegger
Journal:  Helv Chim Acta       Date:  1976-06-14       Impact factor: 2.164

3.  Hypersensitivity in mice. I. Induction of contact sensitivity to oxazolone and inhibition by various chemical compounds.

Authors:  F M Dietrich; R Hess
Journal:  Int Arch Allergy Appl Immunol       Date:  1970

4.  [New cyclopeptides from Trichoderma polysporum (Link ex Pers.) Rifai: cyclosporins B, D and E (author's transl)].

Authors:  R Traber; M Kuhn; H R Loosli; W Pache; A von Wartburg
Journal:  Helv Chim Acta       Date:  1977       Impact factor: 2.164

5.  Effects of the new anti-lymphocytic peptide cyclosporin A in animals.

Authors:  J F Borel; C Feurer; C Magnée; H Stähelin
Journal:  Immunology       Date:  1977-06       Impact factor: 7.397

6.  Immunization of normal mouse spleen cell suspensions in vitro.

Authors:  R I Mishell; R W Dutton
Journal:  Science       Date:  1966-08-26       Impact factor: 47.728
  6 in total
  8 in total

1.  Comparative pharmacokinetics of cyclosporine and NVa2-cyclosporine in dogs.

Authors:  R Venkataramanan; S Todo; I Zaghloul; S Lynch; I Kam; R J Ptachcinski; G J Burckart; T E Starzl
Journal:  Transplant Proc       Date:  1987-02       Impact factor: 1.066

2.  Successful treatment of autoimmunity in (NZB X NZW)F1 mice with cyclosporin and (Nva2)-cyclosporin: II. Reduction of glomerulonephritis.

Authors:  H C Gunn; B Ryffel
Journal:  Clin Exp Immunol       Date:  1986-05       Impact factor: 4.330

3.  Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin.

Authors:  E J Griffiths; A P Halestrap
Journal:  Biochem J       Date:  1991-03-01       Impact factor: 3.857

4.  Canine liver transplantation under Nva2-cyclosporine versus cyclosporine.

Authors:  S Todo; K A Porter; I Kam; S Lynch; R Venkataramanan; A DeWolf; T E Starzl
Journal:  Transplantation       Date:  1986-03       Impact factor: 4.939

Review 5.  New immunosuppressive agents for pediatric transplantation.

Authors:  M Ferraresso; B D Kahan
Journal:  Pediatr Nephrol       Date:  1993-10       Impact factor: 3.714

6.  Successful treatment of autoimmunity in (NZB X NZW)F1 mice with cyclosporin and (Nva2)-cyclosporin: I. Reduction of autoantibodies.

Authors:  H C Gunn
Journal:  Clin Exp Immunol       Date:  1986-05       Impact factor: 4.330

7.  Preventive and therapeutic effects of cyclosporin and valine2-dihydro-cyclosporin in chronic relapsing experimental allergic encephalomyelitis in the Lewis rat.

Authors:  C Feurer; L H Chow; J F Borel
Journal:  Immunology       Date:  1988-02       Impact factor: 7.397

8.  Comparative study of effects of cyclosporins A and G on collagen arthritis in mice.

Authors:  K Takagishi; M Yamamoto; H Miyahara; T Hotokebuchi; N Kaibara
Journal:  Agents Actions       Date:  1992-11
  8 in total

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