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Literature DB >> 5917547

Immunization of normal mouse spleen cell suspensions in vitro.

Abstract

Dissociated cells from the spleens of unimmunized mice were cultured with and without various mammalian erythrocytes. Spleen cell suspensions cultured with heterologous red cells developed levels of hemolytic plaque-forming cells only one log(2) less than those seen in vivo. The reaction is specific for the in vitro immunizing erythrocytes. Antibody was demonstrated in the culture fluids.

Entities: Species

Mesh：

Year: 1966 PMID： 5917547 DOI： 10.1126/science.153.3739.1004

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

57 in total

1. Blocking of primary in vitro antibody responses to thymus-independent and thymus-dependent antigens with antiserum specific for IgM or IgD.

Authors: J C Cambier; F S Ligler; J W Uhr; J R Kettman; E S Vitetta
Journal: Proc Natl Acad Sci U S A Date: 1978-01 Impact factor: 11.205

2. Activation and expansion of hapten- and protein-specific T helper cells from nonsensitized mice.

Authors: C Hauser; S I Katz
Journal: Proc Natl Acad Sci U S A Date: 1988-08 Impact factor: 11.205

3. Lymphoid tissue architecture. Experimental analysis of the origin and distribution of T-cells and B-cells.

Authors: G A Gutman; I L Weissman
Journal: Immunology Date: 1972-10 Impact factor: 7.397

4. The immune response of spleen explants from primed rabbits to sheep red cells (SRC). I. DNA synthesis in the development of antibody-producing cells (PEC).

Authors: G Harris
Journal: Immunology Date: 1973-02 Impact factor: 7.397

Immunization of normal mouse spleen cell suspensions in vitro.

1. Blocking of primary in vitro antibody responses to thymus-independent and thymus-dependent antigens with antiserum specific for IgM or IgD.

2. Activation and expansion of hapten- and protein-specific T helper cells from nonsensitized mice.

3. Lymphoid tissue architecture. Experimental analysis of the origin and distribution of T-cells and B-cells.

4. The immune response of spleen explants from primed rabbits to sheep red cells (SRC). I. DNA synthesis in the development of antibody-producing cells (PEC).

5. Immunogenic potency of human gamma-globulin in mice.

6. Comparison of the pharmacological profiles of cyclosporine, (Nva2)-cyclosporine and (Val2)dihydro-cyclosporine.

Review 7. Beyond oxidative stress: an immunologist's guide to reactive oxygen species.

8. Anti-thymocyte serum may enhance or suppress the response to the same antigenic determinant.

9. Infectious mononucleosis: immunoglobulin synthesis by cell lines.

10. Specific suppression of the antibody response by antibodies to receptors.