Literature DB >> 1706598

Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin.

E J Griffiths1, A P Halestrap.   

Abstract

The Ki values of cyclosporins A, G and H for the peptidyl-prolyl cis-trans isomerase (PPIase) of liver and heart mitochondria are about 2, 20 and 500 nM respectively. This parallels their profile as inhibitors of non-specific pore opening of mitochondria induced by supraphysiological Ca2+ concentrations. The novel immunosuppressant FK-506 gave little inhibition of either process at 5 microM. These data support our previous hypothesis [Halestrap & Davidson (1990) Biochem. J. 268, 153-160] that pore opening involves an interaction between matrix PPIase and the adenine nucleotide translocase. It is suggested that this model may help to clarify the mechanism of action of cyclosporin as an immunosuppressant and its toxic effects on the liver and kidney following prolonged therapy.

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Year:  1991        PMID： 1706598      PMCID： PMC1150183          DOI： 10.1042/bj2740611

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  27 in total

1.  Pore-like and carrier-like properties of the mitochondrial aspartate/glutamate carrier after modification by SH-reagents: evidence for a performed channel as a structural requirement of carrier-mediated transport.

Authors:  T Dierks; A Salentin; R Krämer
Journal:  Biochim Biophys Acta       Date:  1990-10-19

2.  Protein-disulphide isomerase and prolyl isomerase act differently and independently as catalysts of protein folding.

Authors:  K Lang; F X Schmid
Journal:  Nature       Date:  1988-02-04       Impact factor: 49.962

3.  Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress.

Authors:  M Crompton; H Ellinger; A Costi
Journal:  Biochem J       Date:  1988-10-01       Impact factor: 3.857

4.  Effect of cyclosporin A on lymphocyte activation by the calcium ionophore A23187.

Authors:  J E Kay; C R Benzie; A F Borghetti
Journal:  Immunology       Date:  1983-11       Impact factor: 7.397

5.  A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin.

Authors:  J J Siekierka; S H Hung; M Poe; C S Lin; N H Sigal
Journal:  Nature       Date:  1989-10-26       Impact factor: 49.962

6.  A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase.

Authors:  M W Harding; A Galat; D E Uehling; S L Schreiber
Journal:  Nature       Date:  1989-10-26       Impact factor: 49.962

7.  Cyclosporine--relationship of side effects to mode of action.

Authors:  B Ryffel; B M Foxwell; A Gee; B Greiner; G Woerly; M J Mihatsch
Journal:  Transplantation       Date:  1988-08       Impact factor: 4.939

8.  Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins.

Authors:  G Fischer; B Wittmann-Liebold; K Lang; T Kiefhaber; F X Schmid
Journal:  Nature       Date:  1989-02-02       Impact factor: 49.962

9.  The ninaA gene required for visual transduction in Drosophila encodes a homologue of cyclosporin A-binding protein.

Authors:  B H Shieh; M A Stamnes; S Seavello; G L Harris; C S Zuker
Journal:  Nature       Date:  1989-03-02       Impact factor: 49.962

10.  Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin.

Authors:  N Takahashi; T Hayano; M Suzuki
Journal:  Nature       Date:  1989-02-02       Impact factor: 49.962
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  55 in total

Review 1.  Mitochondrial intermembrane junctional complexes and their role in cell death.

Authors:  M Crompton
Journal:  J Physiol       Date:  2000-11-15       Impact factor: 5.182

2.  Cyclosporin A induces the opening of a potassium-selective channel in higher plant mitochondria.

Authors:  E Petrussa; V Casolo; E Braidot; E Chiandussi; F Macrì; A Vianello
Journal:  J Bioenerg Biomembr       Date:  2001-04       Impact factor: 2.945

3.  Genetic ablation of calcium-independent phospholipase A(2)γ (iPLA(2)γ) attenuates calcium-induced opening of the mitochondrial permeability transition pore and resultant cytochrome c release.

Authors:  Sung Ho Moon; Christopher M Jenkins; Michael A Kiebish; Harold F Sims; David J Mancuso; Richard W Gross
Journal:  J Biol Chem       Date:  2012-07-09       Impact factor: 5.157

Review 4.  The mitochondrial permeability transition in neurologic disease.

Authors:  M D Norenberg; K V Rama Rao
Journal:  Neurochem Int       Date:  2007-03-04       Impact factor: 3.921

5.  Cyclosporin A in left ventricular remodeling after myocardial infarction.

Authors:  Andaleb Kholmukhamedov; Christina Logdon; Jiangting Hu; Richard A McKinney; Francis G Spinale; John J Lemasters; Rupak Mukherjee
Journal:  Am J Physiol Heart Circ Physiol       Date:  2013-10-25       Impact factor: 4.733

6.  Prevention of Cyclophilin D-Mediated mPTP Opening Using Cyclosporine-A Alleviates the Elevation of Necroptosis, Autophagy and Apoptosis-Related Markers Following Global Cerebral Ischemia-Reperfusion.

Authors:  Farinoosh Fakharnia; Fariba Khodagholi; Leila Dargahi; Abolhassan Ahmadiani
Journal:  J Mol Neurosci       Date:  2016-09-23       Impact factor: 3.444

7.  Effects of cyclosporin and FK-506 on glomerular mesangial cells. Evidence for direct inhibition of thromboxane synthase by low cyclosporin concentrations.

Authors:  H H Radeke; S Kuster; V Kaever; K Resch
Journal:  Eur J Clin Pharmacol       Date:  1993       Impact factor: 2.953

8.  Cyclophilin D is expressed predominantly in mitochondria of gamma-aminobutyric acidergic interneurons.

Authors:  Julie L Hazelton; Maryna Petrasheuskaya; Gary Fiskum; Tibor Kristián
Journal:  J Neurosci Res       Date:  2009-04       Impact factor: 4.164

9.  The mitochondrial phosphate carrier interacts with cyclophilin D and may play a key role in the permeability transition.

Authors:  Anna W C Leung; Pinadda Varanyuwatana; Andrew P Halestrap
Journal:  J Biol Chem       Date:  2008-07-30       Impact factor: 5.157

10.  Direct demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition.

Authors:  K Woodfield; A Rück; D Brdiczka; A P Halestrap
Journal:  Biochem J       Date:  1998-12-01       Impact factor: 3.857
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