Literature DB >> 3886828

ras Oncogene p21 expression is increased in premalignant lesions and high grade bladder carcinoma.

M V Viola, F Fromowitz, S Oravez, S Deb, J Schlom.   

Abstract

ras Oncogene p21 antigen is present in the most superficial cells of the normal bladder urothelium, as demonstrated by immunohistochemical staining. The pattern and intensity of p21 staining of cells in epithelial hyperplasia and low grade bladder carcinoma were similar to that seen in the normal urothelium. In contrast, epithelial cells in "premalignant" (dysplastic) lesions and high grade carcinomas exhibited an intense staining reaction for p21 antigen. ras p21 may be a useful marker for the malignant potential of both premalignant lesions and carcinomas of the bladder.

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Year:  1985        PMID： 3886828      PMCID： PMC2187613          DOI： 10.1084/jem.161.5.1213

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  19 in total

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Journal:  J Anat       Date:  1972-09       Impact factor: 2.610

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Journal:  Nature       Date:  1982-11-11       Impact factor: 49.962

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Journal:  Pathol Annu       Date:  1982

5.  A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene.

Authors:  E P Reddy; R K Reynolds; E Santos; M Barbacid
Journal:  Nature       Date:  1982-11-11       Impact factor: 49.962

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Journal:  Nature       Date:  1982-12-23       Impact factor: 49.962

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Authors:  I J Fidler; I R Hart
Journal:  Science       Date:  1982-09-10       Impact factor: 47.728

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Journal:  Nature       Date:  1982-06-10       Impact factor: 49.962

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10.  Mapping of the urinary bladder: its impact on the concepts of bladder cancer.

Authors:  L G Koss
Journal:  Hum Pathol       Date:  1979-09       Impact factor: 3.466
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  28 in total

Review 1.  Molecular biology of dissemination in bladder cancer--laboratory findings and clinical significance.

Authors:  B J Schmitz-Dräger; F Jankevicius; R Ackermann
Journal:  World J Urol       Date:  1996       Impact factor: 4.226

Review 2.  Incorporating VEGF-targeted therapy in advanced urothelial cancer.

Authors:  Sujata Narayanan; Sandy Srinivas
Journal:  Ther Adv Med Oncol       Date:  2016-09-16       Impact factor: 8.168

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Journal:  Histochem J       Date:  1988-11

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Journal:  Urol Res       Date:  1988

5.  A comparison of tumor-related antigens in male and female breast cancer.

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Journal:  Breast Cancer Res Treat       Date:  1986       Impact factor: 4.872

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Journal:  Am J Pathol       Date:  1990-02       Impact factor: 4.307

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Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

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Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205

9.  Correlation between the expression of oncogenes ras and c-erbB-2 and the biological behavior of bladder tumors.

Authors:  D W Ye; J F Zheng; S X Qian; Y J Ma
Journal:  Urol Res       Date:  1993-01

10.  Expression of Ha-ras oncogene p21 protein in relation to the cell cycle of cultured human tumor cells.

Authors:  B Czerniak; F Herz; R P Wersto; L G Koss
Journal:  Am J Pathol       Date:  1987-03       Impact factor: 4.307
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