Literature DB >> 6290897

Mechanism of activation of a human oncogene.

C J Tabin, S M Bradley, C I Bargmann, R A Weinberg, A G Papageorge, E M Scolnick, R Dhar, D R Lowy, E H Chang.   

Abstract

The oncogene of the human EJ bladder carcinoma cell lines arose via alteration of a cellular proto-oncogene. Experiments are presented that localize the genetic lesion that led to activation of the oncogene. The lesion has no affect on levels of expression of the oncogene. Instead, it affects the structure of the oncogene-encoded protein.

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Year:  1982        PMID： 6290897     DOI： 10.1038/300143a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  366 in total

1.  Dominant transformation by mutated human ras genes in vitro requires more than 100 times higher expression than is observed in cancers.

Authors:  V Y Hua; W K Wang; P H Duesberg
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-02       Impact factor: 11.205

2.  Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53.

Authors:  M M Sugrue; D Y Shin; S W Lee; S A Aaronson
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-02       Impact factor: 11.205

3.  Evolving strategies for the incorporation of bioinformatics within the undergraduate cell biology curriculum.

Authors:  Jerry E Honts
Journal:  Cell Biol Educ       Date:  2003

Review 4.  Somatic cell fusion as a source of genetic rearrangement leading to metastatic variants.

Authors:  L Larizza; V Schirrmacher
Journal:  Cancer Metastasis Rev       Date:  1984       Impact factor: 9.264

5.  Monoclonal antibodies to antigens associated with transitional cell carcinoma of the human urinary bladder. II. Identification of the cellular target structures by immunoprecipitation and SDS-PAGE analysis.

Authors:  S Paulie; H Koho; H Ben-Aissa; Y Hansson; M L Lundblad; P Perlmann
Journal:  Cancer Immunol Immunother       Date:  1984       Impact factor: 6.968

Review 6.  Clinical and biological significance of aneuploidy in human tumours.

Authors:  M L Friedlander; D W Hedley; I W Taylor
Journal:  J Clin Pathol       Date:  1984-09       Impact factor: 3.411

7.  Monoclonal antibodies of predefined specificity detect activated ras gene expression in human mammary and colon carcinomas.

Authors:  P H Hand; A Thor; D Wunderlich; R Muraro; A Caruso; J Schlom
Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205

8.  Saccharomyces cerevisiae synthesizes proteins related to the p21 gene product of ras genes found in mammals.

Authors:  A G Papageorge; D Defeo-Jones; P Robinson; G Temeles; E M Scolnick
Journal:  Mol Cell Biol       Date:  1984-01       Impact factor: 4.272

9.  ATP-binding site of adenylate kinase: mechanistic implications of its homology with ras-encoded p21, F1-ATPase, and other nucleotide-binding proteins.

Authors:  D C Fry; S A Kuby; A S Mildvan
Journal:  Proc Natl Acad Sci U S A       Date:  1986-02       Impact factor: 11.205

10.  Accurate and efficient transcription of human c-myc genes injected into Xenopus laevis oocytes.

Authors:  K Nishikura; S Goldflam; G A Vuocolo
Journal:  Mol Cell Biol       Date:  1985-06       Impact factor: 4.272
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