Literature DB >> 3886023

Vitamin B6, magnesium, and combined B6-Mg: therapeutic effects in childhood autism.

J Martineau, C Barthelemy, B Garreau, G Lelord.   

Abstract

This article reports the behavioral, biochemical, and electrophysiological effects of four therapeutic crossed-sequential double-blind trials with 60 autistic children: Trial A--vitamin B6 plus magnesium/magnesium; Trial B--vitamin B6 plus magnesium; Trial C--magnesium; and Trial D--vitamin B6. Therapeutic effects were controlled using behavior rating scales, urinary excretion of homovanillic acid (HVA), and evoked potential (EP) recordings. The behavioral improvement observed with the combination vitamin B6-magnesium was associated with significant modifications of both biochemical and electrophysiological parameters: the urinary HVA excretion decreased, and EP amplitude and morphology seemed to be normalized. These changes were not observed when either vitamin B6 or magnesium was administered alone.

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Year:  1985        PMID： 3886023     DOI： 10.1016/0006-3223(85)90019-8

Source DB:  PubMed          Journal:  Biol Psychiatry        ISSN： 0006-3223            Impact factor:   13.382


  20 in total

Review 1.  Prognosis in autism: do specialist treatments affect long-term outcome?

Authors:  P Howlin
Journal:  Eur Child Adolesc Psychiatry       Date:  1997-06       Impact factor: 4.785

2.  Brief report: an open middle-term study of combined vitamin B6-magnesium in a subgroup of autistic children selected on their sensitivity to this treatment.

Authors:  J Martineau; C Barthelemy; C Cheliakine; G Lelord
Journal:  J Autism Dev Disord       Date:  1988-09

3.  Brief report: lack of response in an autistic population to a low dose clinical trial of pyridoxine plus magnesium.

Authors:  L Tolbert; T Haigler; M M Waits; T Dennis
Journal:  J Autism Dev Disord       Date:  1993-03

Review 4.  Efficacy of vitamin B6 and magnesium in the treatment of autism: a methodology review and summary of outcomes.

Authors:  S I Pfeiffer; J Norton; L Nelson; S Shott
Journal:  J Autism Dev Disord       Date:  1995-10

5.  Investigation of whole blood and urine monoamines in autism.

Authors:  Josiane Hérault; Joëlle Martineau; Anne Perrot-Beaugerie; Jacqueline Jouve; Hervé Tournade; Catherine Barthelemy; Gilbert Lelord; Jean-Pierre Muh
Journal:  Eur Child Adolesc Psychiatry       Date:  1993-10       Impact factor: 4.785

6.  Childhood autism: An appeal for an integrative and psychobiological approach.

Authors:  Robert D Oades; Christian Eggers
Journal:  Eur Child Adolesc Psychiatry       Date:  1994-07       Impact factor: 4.785

Review 7.  Advances in drug treatments for children and adolescents with autism and other pervasive developmental disorders.

Authors:  Richard P Malone; Silvia S Gratz; Mary Anne Delaney; Susan B Hyman
Journal:  CNS Drugs       Date:  2005       Impact factor: 5.749

8.  High-dose pyridoxine and magnesium administration in children with autistic disorder: an absence of salutary effects in a double-blind, placebo-controlled study.

Authors:  R L Findling; K Maxwell; L Scotese-Wojtila; J Huang; T Yamashita; M Wiznitzer
Journal:  J Autism Dev Disord       Date:  1997-08

9.  The Behavioral Summarized Evaluation: validity and reliability of a scale for the assessment of autistic behaviors.

Authors:  C Barthelemy; J L Adrien; P Tanguay; B Garreau; J Fermanian; S Roux; D Sauvage; G Lelord
Journal:  J Autism Dev Disord       Date:  1990-06

10.  Supplement intervention associated with nutritional deficiencies in autism spectrum disorders: a systematic review.

Authors:  Yong-Jiang Li; Ya-Min Li; Da-Xiong Xiang
Journal:  Eur J Nutr       Date:  2017-09-07       Impact factor: 5.614
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