Literature DB >> 29871438

Investigation of whole blood and urine monoamines in autism.

Josiane Hérault1, Joëlle Martineau2, Anne Perrot-Beaugerie2, Jacqueline Jouve1, Hervé Tournade1, Catherine Barthelemy2, Gilbert Lelord2, Jean-Pierre Muh1.   

Abstract

Levels of serotonin (5-HT), dopamine (DA), norepinephrine (NE) and epinephrine (E) were determined in the whole blood and urine of 23 children with autism and compared to those of normal children. Very significant group effects (low whole blood 5-HT, high urinary 5-HT and high NE+E in autism) and age effects (urinary 5-HT and DA decrease with age) were found. Moreover, the urinary DA and the whole blood E levels were correlated with clinical findings. The results suggest a maturation defect of noradrenergic systems, possibly disturbed dopaminergic and serotoninergic metabolism, and a functional imbalance among these neurotransmitters in autism.

Entities:  

Keywords:  Adrenalin; Dopamine; Monoamine; Noradrenalin; Serotonin

Year:  1993        PMID： 29871438     DOI： 10.1007/BF02098580

Source DB:  PubMed          Journal:  Eur Child Adolesc Psychiatry        ISSN： 1018-8827            Impact factor:   4.785


  46 in total

1.  [Determination of urinary creatinine].

Authors:  M PAGET; M GONTIER; J LIEFOOGHE
Journal:  Ann Biol Clin (Paris)       Date:  1955 Oct-Dec       Impact factor: 0.459

2.  Autistic children and their first-degree relatives: relationships between serotonin and norepinephrine levels and intelligence.

Authors:  E H Cook; B L Leventhal; W Heller; J Metz; M Wainwright; D X Freedman
Journal:  J Neuropsychiatry Clin Neurosci       Date:  1990       Impact factor: 2.198

3.  Serotonin metabolism and other biochemical parameters in infantile autism. A controlled study of 22 autistic children.

Authors:  J M Launay; P Ferrari; M Haimart; C Bursztejn; F Tabuteau; A Braconnier; D Pasques-Bondoux; C Luong; C Dreux
Journal:  Neuropsychobiology       Date:  1988       Impact factor: 2.328

Review 4.  Catecholamine metabolism: basic aspects and clinical significance.

Authors:  I J Kopin
Journal:  Pharmacol Rev       Date:  1985-12       Impact factor: 25.468

5.  Increased blood serotonin and platelets in early infantile autism.

Authors:  E R Ritvo; A Yuwiler; E Geller; E M Ornitz; K Saeger; S Plotkin
Journal:  Arch Gen Psychiatry       Date:  1970-12

6.  Levodopa and levoamphetamine: a crossover study in young schizophrenic children.

Authors:  M Campbell; A M Small; P J Collins; E Friedman; R David; N Genieser
Journal:  Curr Ther Res Clin Exp       Date:  1976-01

7.  Behavior checklist for identifying severely handicapped individuals with high levels of autistic behavior.

Authors:  D A Krug; J Arick; P Almond
Journal:  J Child Psychol Psychiatry       Date:  1980-07       Impact factor: 8.982

8.  Haloperidol in the treatment of infantile autism: effects on learning and behavioral symptoms.

Authors:  L T Anderson; M Campbell; D M Grega; R Perry; A M Small; W H Green
Journal:  Am J Psychiatry       Date:  1984-10       Impact factor: 18.112

9.  Behavioral characteristics of high- and low-IQ autistic children.

Authors:  B J Freeman; E R Ritvo; P C Schroth; I Tonick; D Guthrie; L Wake
Journal:  Am J Psychiatry       Date:  1981-01       Impact factor: 18.112

10.  Vitamin B6, magnesium, and combined B6-Mg: therapeutic effects in childhood autism.

Authors:  J Martineau; C Barthelemy; B Garreau; G Lelord
Journal:  Biol Psychiatry       Date:  1985-05       Impact factor: 13.382
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  2 in total

1.  Altered Urinary Amino Acids in Children With Autism Spectrum Disorders.

Authors:  Aiping Liu; Wei Zhou; Liuhong Qu; Fusheng He; Hui Wang; Yan Wang; Chunquan Cai; Xiaoge Li; Wenhao Zhou; Mingbang Wang
Journal:  Front Cell Neurosci       Date:  2019-01-25       Impact factor: 5.505

2.  Gene-Environment Interactions in Developmental Neurotoxicity: a Case Study of Synergy between Chlorpyrifos and CHD8 Knockout in Human BrainSpheres.

Authors:  Sergio Modafferi; Xiali Zhong; Andre Kleensang; Yohei Murata; Francesca Fagiani; David Pamies; Helena T Hogberg; Vittorio Calabrese; Herbert Lachman; Thomas Hartung; Lena Smirnova
Journal:  Environ Health Perspect       Date:  2021-07-14       Impact factor: 9.031
  2 in total

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