Literature DB >> 3885605

The relationship to knobs of the 92,000 D protein specific for knobby strains of Plasmodium falciparum.

J P Vernot-Hernandez, H G Heidrich.   

Abstract

A 92,000 D protein was identified associated with the membrane of host erythrocytes infected with the FCB1 Plasmodium falciparum strain from Colombia. The same protein was identified in the knob-forming Gambian (and the Malayan Camp) strain, but was not present in all the corresponding knobless strains. In the FCB1 strain as well as in the FCR3 strain the protein is synthesized during the ring-stage period. The cleavage products of the 92,000 D protein were investigated by peptide mapping following limited proteolytic digestion with Staphylococcus aureus V8 protease. The 92,000 D protein cleavage products from both the Colombian and the Gambian strains were identical. Moreover, both the proteins were sensitive to trypsin and chymotrypsin and also to treatment with neuraminidase. Enzymatic removal of the protein from the erythrocyte membrane by trypsin or chymotrypsin did not affect parasite maturation. The merozoites thus produced were fully invasive and the morphology of the knobs was unaltered. When the erythrocyte membrane was treated with trypsin before the time of synthesis of the 92,000 D protein, it was not possible to identify the protein in membranes of later stages of infected erythrocytes, indicating that the protein cannot be inserted into the membrane cytoskeleton compartment. Knobs, however, were formed more or less normally, suggesting that it is not the accumulation of this protein which products the knobs.

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Year:  1985        PMID: 3885605     DOI: 10.1007/bf00932917

Source DB:  PubMed          Journal:  Z Parasitenkd        ISSN: 0044-3255


  27 in total

1.  Isolation of stages of the human parasite Plasmodium falciparum from culture and from animal blood.

Authors:  R T Reese; S G Langreth; W Trager
Journal:  Bull World Health Organ       Date:  1979       Impact factor: 9.408

2.  Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

Authors:  D W Cleveland; S G Fischer; M W Kirschner; U K Laemmli
Journal:  J Biol Chem       Date:  1977-02-10       Impact factor: 5.157

3.  Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane.

Authors:  G Fairbanks; T L Steck; D F Wallach
Journal:  Biochemistry       Date:  1971-06-22       Impact factor: 3.162

4.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

5.  The effects of proteases on proteins and glycoproteins of Dictyostelium discoideum plasma membranes.

Authors:  R W Parish; S Schmidlin; U Müller
Journal:  Exp Cell Res       Date:  1977-12       Impact factor: 3.905

6.  Expression of strain-specific surface antigens on Plasmodium falciparum-infected erythrocytes.

Authors:  M Hommel; P H David; L D Oligino; J R David
Journal:  Parasite Immunol       Date:  1982-11       Impact factor: 2.280

7.  Plasmodium falciparum malaria. Ultrastructure of parasitized erythrocytes in cardiac vessels.

Authors:  S A Luse; L H Miller
Journal:  Am J Trop Med Hyg       Date:  1971-09       Impact factor: 2.345

8.  Free-flow electrophoresis for the separation of malaria infected and uninfected mouse erythrocytes and for the isolation of free parasites (Plasmodium vinckei): a new rapid technique for the liberation of malaria parasites from their host cells.

Authors:  H G Heidrich; L Rüssmann; B Bayer; A Jung
Journal:  Z Parasitenkd       Date:  1979-02-28

9.  The fine structure of Plasmodium falciparum and its host erythrocytes in natural malarial infections in man.

Authors:  W Trager; M A Rudzinska; P C Bradbury
Journal:  Bull World Health Organ       Date:  1966       Impact factor: 9.408

10.  Antigenicity of the infected-erythrocyte and merozoite surfaces in Falciparum malaria.

Authors:  S G Langreth; R T Reese
Journal:  J Exp Med       Date:  1979-11-01       Impact factor: 14.307

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  11 in total

1.  Antibodies to a histidine-rich protein (PfHRP1) disrupt spontaneously formed Plasmodium falciparum erythrocyte rosettes.

Authors:  J Carlson; G Holmquist; D W Taylor; P Perlmann; M Wahlgren
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

2.  Fractionation of Plasmodium chabaudi-infected erythrocytes into parasites and ghosts.

Authors:  F Wunderlich; G Schillinger; M Helwig
Journal:  Z Parasitenkd       Date:  1985

3.  A 46,000 dalton Plasmodium falciparum merozoite surface glycoprotein not related to the 185,000-195,000 dalton schizont precursor molecule: isolation and characterization.

Authors:  A Miettinen-Baumann; W Strych; J McBride; H G Heidrich
Journal:  Parasitol Res       Date:  1988       Impact factor: 2.289

Review 4.  Plasmodium falciparum antigens as target molecules for a protective immunization against malaria: an up-to-date review.

Authors:  H G Heidrich
Journal:  Z Parasitenkd       Date:  1986

5.  Primary structure and subcellular localization of the knob-associated histidine-rich protein of Plasmodium falciparum.

Authors:  L G Pologe; A Pavlovec; H Shio; J V Ravetch
Journal:  Proc Natl Acad Sci U S A       Date:  1987-10       Impact factor: 11.205

6.  Isolation and characterization of the 80,000 dalton Plasmodium falciparum merozoite surface antigen.

Authors:  W Strych; A Miettinen-Baumann; F Lottspeich; H G Heidrich
Journal:  Parasitol Res       Date:  1987       Impact factor: 2.289

7.  Accessibility and distribution of intraerythrocytic antigens of Plasmodium-infected erythrocytes following mild glutaraldehyde fixation and detergent extraction.

Authors:  M F Wiser; L V Faur; H N Lanners; M Kelly; R B Wilson
Journal:  Parasitol Res       Date:  1993       Impact factor: 2.289

8.  Expression of the histidine-rich protein PfHRP1 by knob-positive Plasmodium falciparum is not sufficient for cytoadherence of infected erythrocytes.

Authors:  E P Rock; A J Saul; D W Taylor; J H Leech; J A Sherwood; R J Howard
Journal:  Infect Immun       Date:  1988-12       Impact factor: 3.441

9.  Characterization of a modified red cell membrane protein expressed on erythrocytes infected with the human malaria parasite Plasmodium falciparum: possible role as a cytoadherent mediating protein.

Authors:  E Winograd; I W Sherman
Journal:  J Cell Biol       Date:  1989-01       Impact factor: 10.539

10.  Secretion of a malarial histidine-rich protein (Pf HRP II) from Plasmodium falciparum-infected erythrocytes.

Authors:  R J Howard; S Uni; M Aikawa; S B Aley; J H Leech; A M Lew; T E Wellems; J Rener; D W Taylor
Journal:  J Cell Biol       Date:  1986-10       Impact factor: 10.539

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