Literature DB >> 3290892

A 46,000 dalton Plasmodium falciparum merozoite surface glycoprotein not related to the 185,000-195,000 dalton schizont precursor molecule: isolation and characterization.

A Miettinen-Baumann1, W Strych, J McBride, H G Heidrich.   

Abstract

A 46,000 dalton glycoprotein was isolated by extraction of freshly harvested P. falciparum merozoites (FCB1 strain), followed by gel electrophoresis of the extract and electroelution. The antigen is present in the late ring, trophozoite, schizont, and segmenter stages and is localized on the merozoite surface at the end of schizogony. It is not related to the 185,000-195,000 dalton schizont antigen. An antiserum against the 46,000 dalton antigen inhibits invasion of erythrocytes by merozoites. The isolated antigen is identical to the antigen against which monoclonal antibody (mcab) 13.4 is directed.

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Year:  1988        PMID： 3290892     DOI： 10.1007/bf00539452

Source DB:  PubMed          Journal:  Parasitol Res        ISSN： 0932-0113            Impact factor:   2.289


  22 in total

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Authors:  R T Reese; S G Langreth; W Trager
Journal:  Bull World Health Organ       Date:  1979       Impact factor: 9.408

2.  Kinetic constraints on the development of a malaria vaccine.

Authors:  A Saul
Journal:  Parasite Immunol       Date:  1987-01       Impact factor: 2.280

3.  Epitope map and processing scheme for the 195,000-dalton surface glycoprotein of Plasmodium falciparum merozoites deduced from cloned overlapping segments of the gene.

Authors:  J A Lyon; R H Geller; J D Haynes; J D Chulay; J L Weber
Journal:  Proc Natl Acad Sci U S A       Date:  1986-05       Impact factor: 11.205

4.  Processing of the precursor to the major merozoite surface antigens of Plasmodium falciparum.

Authors:  A A Holder; J S Sandhu; Y Hillman; L S Davey; S C Nicholls; H Cooper; M J Lockyer
Journal:  Parasitology       Date:  1987-04       Impact factor: 3.234

5.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors:  H Towbin; T Staehelin; J Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

6.  The relationship to knobs of the 92,000 D protein specific for knobby strains of Plasmodium falciparum.

Authors:  J P Vernot-Hernandez; H G Heidrich
Journal:  Z Parasitenkd       Date:  1985

7.  Isolation of microgram quantities of proteins from polyacrylamide gels for amino acid sequence analysis.

Authors:  M W Hunkapiller; E Lujan; F Ostrander; L E Hood
Journal:  Methods Enzymol       Date:  1983       Impact factor: 1.600

8.  Antisperm antibodies in mouse vasectomy sera react with embryonal teratocarcinoma.

Authors:  D J Anderson; P H Adams; M S Hamilton; N J Alexander
Journal:  J Immunol       Date:  1983-12       Impact factor: 5.422

9.  Recognition of a Mr 56K glycoprotein on the surface of Plasmodium falciparum merozoites by mouse monoclonal antibodies.

Authors:  H A Stanley; R F Howard; R T Reese
Journal:  J Immunol       Date:  1985-05       Impact factor: 5.422

10.  Surface antigens of malaria merozoites. A high molecular weight precursor is processed to an 83,000 mol wt form expressed on the surface of Plasmodium falciparum merozoites.

Authors:  R R Freeman; A A Holder
Journal:  J Exp Med       Date:  1983-11-01       Impact factor: 14.307
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  5 in total

1.  Evidence for surface-coat localisation of a monoclonal antibody-isolated merozoite antigen of Babesia divergens.

Authors:  C M Winger; E U Canning; R H Hartley; A Gunn
Journal:  Parasitol Res       Date:  1990       Impact factor: 2.289

2.  Development of natural immunity in Plasmodium falciparum malaria: study of antibody response by Western immunoblotting.

Authors:  J Thelu; I Sheick-Zakiuddin; C Boudin; F Peyron; S Picot; P Ambroise-Thomas
Journal:  J Clin Microbiol       Date:  1991-03       Impact factor: 5.948

3.  Structural and antigenic polymorphism of the 35- to 48-kilodalton merozoite surface antigen (MSA-2) of the malaria parasite Plasmodium falciparum.

Authors:  B Fenton; J T Clark; C M Khan; J V Robinson; D Walliker; R Ridley; J G Scaife; J S McBride
Journal:  Mol Cell Biol       Date:  1991-02       Impact factor: 4.272

4.  Plasmodium falciparum merozoite surface protein 2 is unstructured and forms amyloid-like fibrils.

Authors:  Christopher G Adda; Vince J Murphy; Margaret Sunde; Lynne J Waddington; Jesse Schloegel; Gert H Talbo; Kleo Vingas; Vivian Kienzle; Rosella Masciantonio; Geoffrey J Howlett; Anthony N Hodder; Michael Foley; Robin F Anders
Journal:  Mol Biochem Parasitol       Date:  2009-04-09       Impact factor: 1.759

5.  A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion-inhibiting antibodies.

Authors:  M J Blackman; H G Heidrich; S Donachie; J S McBride; A A Holder
Journal:  J Exp Med       Date:  1990-07-01       Impact factor: 14.307
  5 in total

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